Brain distribution of nitric oxide synthase in neuronal or endothelial nitric oxide synthase mutant mice using [3H]L-N(G)-nitro-arginine autoradiography

Neuroscience

Volumn 75, Issue 3, 1996, Pages 881-890

  Hara, H ^a   Waeber, C ^a   Huang, P L ^a   Fujii, M ^a   Fishman, M C ^a   Moskowitz, M A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

autoradiography; brain; L N(G) nitro arginine; mouse; mutant; nitric oxide synthase

Indexed keywords

7 NITROINDAZOLE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN REGION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; MALE; MOUSE; MUTANT; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030561271     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-4522(96)00313-2     Document Type: Article

References (35)

1. 1. Babbedge R. C., Bland-Ward P. A., Hart S. L. and Moore P. K. (1993) Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles. Br. J. Pharmac. 110, 225-228.
2. 2. Bredt D. S., Blatt C. E., Hwang P. M., Fotuhi M., Dawson T. M. and Snyder S. H. (1991) Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron 7, 615-624.
3. 3. Bredt D. S. and Snyder S. H. (1990) Isolation of nitric oxide synthetase, a calmoduline-requiring enzyme. Proc. natn. Acad. Sci. U.S.A. 87, 682-685.
4. 4. Bredt D. S. and Snyder S. H. (1992) Nitric oxide, a novel neuronal messenger. Neuron 8, 3-11.
5. 5. Bredt D. S. and Snyder S. H. (1994) Nitric oxide: a physiologic messenger molecule. A. Rev. Biochem. 63, 175-195.
6. 6. Brenman J. E., Chao D. S., Gee S. H., McGee A. W., Craven S. E., Santillano D. R., Wu Z., Huang F., Xia H., Peters M. F., Froehner S. C. and Bredt D. S. (1996) Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α1-syntrophin mediated by PDZ domains. Cell 84, 757-767.
7. G-nitro-arginine autoradiography. NeuroReport 6, 1842-1844.
8. 8. Curran R. D., Billiar T. R., Stuehr D. J., Hofman K. and Simmons R. L. (1989) Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. J. exp. Med. 170, 1769-1774.
9. 9. Darius S., Wolf G., Huang P. L. and Fishman M. C. (1995) Localization of NADPH-diaphorase/nitric oxide synthase in the rat retina: an electron microscopic study. Brain Res. 690, 231-235.
10. 10. Dinerman J. L., Dawson T. M., Schell M. J., Snowman A. and Snyder S. H. (1994) Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: Implications for synaptic plasticity. Proc. natn. Acad. Sci. U.S.A. 91, 4214-4218.
11. G-nitro-arginine autoradiography. Stroke 27, 190.
12. 12. Huang P. L., Dawson T. M., Bredt D. S., Snyder S. H. and Fishman M. C. (1993) Targeted disruption of the neuronal nitric oxide synthase gene. Cell 75, 1273-1286.
13. 13. Huang P. L., Huang Z., Mashima H., Block K. D., Moskowitz M. A., Bevan J. A. and Fishman M. C. (1995) Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377, 239-242.
14. 14. Huang Z., Huang P. L., Panahian N., Dalkara T., Fishman M. C. and Moskowitz M. A. (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265, 1883-1885.
15. 15. Irikura K., Huang P. L., Ma J., Lee W. S., Dalkara T., Fishman M. C., Dawson T. M., Snyder S. H. and Moskowitz M. A. (1995) Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression. Proc. natn. Acad. Sci. U.S.A. 92, 6823-6827.
16. G-nitro-arginine binding in rat brain. Neuropharmacology 34, 63-73.
17. 17. Kuhar M. J. and Unnerstall J. R. (1985) Quantitative receptor mapped by autoradiography: some current technical problems. Trends Neurosci. 8, 49-53.
18. 18. Lamas S., Marsden P. A., Li G. K., Tempst P. and Michael T. (1992) Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc. natn. Acad. Sci. U.S.A. 89, 6348-6352.
19. 19. Ma J., Ayata C., Huang P. L., Fishman M. C. and Moskowitz M. A. (1996) Regional cerebral blood flow response to vibrissal stimulation in mice lacking type I NOS gene expression. Am. J. Physiol. 270, H1085-H1090.
20. 20. Mayer B., Klatt P., Werner E. R. and Schmidt K. (1994) Molecular mechanisms of inhibition of porcine brain nitric oxide synthase by the antinociceptive drug 7-nitro-indazole. Neuropharmacology 33, 1253-1259.
21. G-nitro-arginine in rat brain. Br. J. Pharmac. 109, 287-288.
22. 22. Moncada S. (1992) The L-arginine: nitric oxide pathway. Acta physiol. scand. 145, 201-227.
23. 23. Moore P. K., Babbedge R. C., Wallace P., Gaffen Z. A. and Hart S. L. (1993) 7-Nitroindazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br. J. Pharmac. 108, 296-297.
24. 24. Moore P. K., Wallace P., Gaffen Z., Hart S. L. and Babbedge R. C. (1993) Characterization of the novel nitric oxide synthase inhibitor 7-nitroindazole and related indazoles: antinociceptive and cardiovascular effects. Br. J. Pharmac. 110, 219-224.
25. 25. O'Dell T. J., Huang P. L., Dawson T. M., Dinerman J. L., Snyder S. H., Kandel E. R. and Fishman M. C. (1994) Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. Science 265, 542-546.
26. 26. Rutherford R. A. D., McCarthy A., Sullivan M. H. F., Elder M. G., Polak J.M. and Wharton J. (1995) Nitric oxide synthase in human placenta and umbilical cord from normal, intrauterine growth-retarded and pre-eclamptic pregnancies. Br. J. Pharmac. 116, 3099-3109.
27. 27. Scatchard G. (1949) The attraction of proteins for small molecules and ions. Ann. N. Y. Acad. Sci. 51, 660-672.
28. 28. Schmidt H. H. H. W., Gagne G. D., Nakane M., Pollock J. S., Miller M. F. and Murad F. (1992) Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction. J. Histochem. Cytochem. 40, 1439-1456.
29. 29. Schulz J. B., Matthews R. T., Jenkins B. G., Ferrante R. J., Siwek D., Henshaw D. R., Cipolloni P. B., Mecocci P., Kowall N. W., Rose B. R. and Beal M. F. (1995) Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo. J. Neurosci. 15, 8419-8429.
30. 30. Schulz J. B., Matthews R. T., Muqit M. M. K., Browne S. E. and Beal M. F. (1995) Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP induced neurotoxicity in mice. J. Neurochem. 64, 936-939.
31. 31. Vincent S. R. and Kimura H. (1992) Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46, 755-784.
32. 4 binding sites in rodent brain. Neuropharmacology 33, 527-541.
33. 33. Wallace M. N. and Fredens K. (1992) Activated astrocytes of the mouse hippocampus contain high levels of NADPH-diaphorase. NeuroReport 3, 953-956.
34. 34. Yoshida T., Limmroth V., Irikura K. and Moskowitz M. A. (1994) The NOS inhibitor, 7-nitroindazole, decreases focal infarct volume but not the response to topical acetylcholine in pial vessels. J. cereb. Blood Flow Metab. 14, 924-929.
35. 35. Yoshida T., Waeber C., Huang Z. and Moskowitz M. A. (1995) Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion. Neurosci. Lett. 194, 214-218.