A3 - A novel colon and pancreatic cancer reactive antibody from a primate phage library selected using intact tumour cells

International Journal of Cancer

Volumn 87, Issue 4, 2000, Pages 559-568

  Tordsson, Jesper ^a   Lavasani, Shahram ^a   Ohlsson, Lennart ^a   Karlström, Pia ^a   Svedberg, Helena ^a   Abrahmsén, Lars ^b   Brodin, Thomas ^a  

^a Active Biotech Research AB   (Sweden)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD GROUP A3 ANTIGEN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOTHERAPY; COLON CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; MACACA; NONHUMAN; PANCREAS CARCINOMA; PHAGE DISPLAY; PRIORITY JOURNAL;

EID: 0033897739     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000815)87:4<559::aid-ijc16>3.0.co;2-%23     Document Type: Article

References (41)

1. Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A
2. Increased affinity leads to improved selective tumor delivery of single-chain Fv antibodies
3. High affinity human antibodies by phage display
4. Colorectal carcinoma invasion inhibition by CO17-1A/GA733 antigen and its murine homologue
5. Hormone phage: An enrichment method for variant proteins with altered binding properties
6. Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody
7. The labelling of proteins to high specific radioactivities by conjugation to a 1251-containing acylating agent
8. Man-made superantigens: Tumor-selective agents for T-cell-based therapy
9. Anti-melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor cells: Selection of specific antibodies from single-chain Fv fusion phage libraries
10. Human lymphocyte hybridomas and monoclonal antibodies
11. Engineering subtilisin BPN for site-specific proteolysis
12. Immunohistochemical analysis of antiserum from rhesus monkeys immunized with human colon carcinoma
13. Mice transgenic for human carcinoembryonic antigen as a model for immunotherapy
14. Colorectal cancer: Detection, treatment, and rehabilitation
15. Characterization of human anti-high molecular weight-melanoma-associated antigen single-chain Fv fragments isolated from a phage display antibody library
16. Monoclonal antibody-superantigen fusion proteins: Tumor-specific agents for T-cell-based tumor therapy
17. Antibody-targeted superantigens are potent inducers of tumor-infiltrating T lymphocytes in vivo
18. Immunotherapy of human colon cancer by antibody-targeted superantigens
19. The epithelial cell surface antigen 17-1A, a target for antibody-mediated tumor therapy: Its biochemical nature, tissue distribution and recognition by different monoclonal antibodies
20. In vitro and in vivo regulation of human tumor antigen expression by human recombinant interferons: A review
21. Immunogenicity of human melanoma-associated antigens defined by murine monoclonal antibodies in allogeneic and xenogeneic hosts
22. Antibody phage display technology and its applications
23. Monoclonal antibodies and colorectal carcinoma: A clinical review of diagnostic applications
24. Cancer statistics, 1999
25. Cloning and sequence analysis of kappa and gamma cynomolgus monkey immunoglobulin cDNAs
26. Antibody-targeted superantigen therapy induces tumor-infiltrating lymphocytes, excessive cytokine production, and apoptosis in human colon carcinoma
27. Ep-CAM: A human epithelial antigen is a homophilic cell-cell adhesion molecule
28. Eradication of large colon tumor xenografts by targeted delivery of maytansinoids
29. Biologic properties of a bispecific single-chain antibody directed against 17-1A (EpCAM) and CD3: Tumor cell-dependent T cell stimulation and cytotoxic activity
30. An EGP-2/Ep-CAM-expressing transgenic rat model to evaluate antibody-mediated immunotherapy
31. Selective loss of HLA-A or HLA-B antigen expression in colon carcinoma
32. Immunobiology and immunotherapy of melanoma
33. 'Primatization' of recombinant antibodies for immunotherapy of human diseases: A macaque/human chimeric antibody against human CD4
34. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma
35. Monoclonal antibody therapy for resected Dukes' C colorectal cancer: Seven-year outcome of a multicenter randomized trial
36. Long-term survival and complete cures of B16 melanoma-carrying animals after therapy with tumor-targeted 1L-2 and SEA
37. Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats
38. The use of non-human primates for production of antisera to human tumor-associated antigens
39. Efficient selection of scFv antibody phage by adsorption to in situ expressed antigens in tissue sections
40. Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates
41. The impact of antigen density and antibody affinity on antibody-dependent cellular cytotoxicity: Relevance for immunotherapy of carcinomas