Pentoxifylline improves learning and memory in glutamate-lesioned rats

Pharmacology Biochemistry and Behavior

Volumn 66, Issue 4, 2000, Pages 687-694

  Cunha, Geanne M A ^a   Bezerra, Paulo Jorge P ^a   Saldanha, Michelle D D ^a   Cavalcante, Marília C ^a   De Brun, Veralice M S ^b   Viana, Glauce S B ^a  

^a Laboratory of Neuropharmacology   (Brazil)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

cAMP; Glutamate; Memory; Pentoxifylline

Indexed keywords

CYCLIC AMP; GLUTAMIC ACID; PENTOXIFYLLINE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; HIPPOCAMPUS; LEARNING; LOCOMOTION; MALE; MAZE TEST; MEMORY; MEMORY CONSOLIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOTAXIC SURGERY;

ANIMALS; AVOIDANCE LEARNING; CYCLIC AMP; GLUTAMIC ACID; HIPPOCAMPUS; LEARNING; MALE; MAZE LEARNING; MEMORY; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, WISTAR; RECEPTORS, GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0033882997     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(00)00279-3     Document Type: Article

References (36)

1. Bernabeu R., Bevilaqua L., Ardenghi P., Bromberg E., Schmitz P., Bianschi M., Izquierdo I., Medina J.H. Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats. Proc. Natl. Acad. Sci. USA. 94:1997;7041-7046.
2. Bernabeu R., Schmitz P., Faillace M.P., Izquierdo I., Medina J.H. Hippocampal cGMP and cAMP are differently involved in memory processing of inhibitory avoidance learning. Neuroreport. 7:1996;585-588.
3. Bondy S.C., Lee D.K. Oxidative stress induced by glutamate receptor agonists. Brain Res. 610:1993;229-233.
4. Bone R.C. Inhibitors of complement and neutrophils. A critical evaluation of their role in the treatment of sepsis Crit. Care Med. 20:1992;891-898.
5. Breakwell N.A., Huang L.Q., Rowan M.J., Anwyl R. DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus. Eur. J. Pharmacol. 322:1997;173-178.
6. Broadhurst P.L. Determinants of emotionality in the rat. I situational factors Br. J. Psychol. 48:1957;1-12.
7. Bureau Y.R.J., Peredery O., Persinger M.A. Concordance of quantitative damage within the diencephalon and telencephalon following systemic pilocarpine (380 mg/Kg) or lithium (3mEq/Kg) pilocarpine (30mg/Kg) induced seizures. Brain Res. 648:1994;265-269.
8. Carswell H.J., Graham D.I., Stone T.W. Kainate-evoked release of adenosine from the hippocampus of the anaesthetized rat. Possible involvement of free radicals J. Neurochem. 68:1997;240-247.
9. Chow J.M., Benowitz N.L. Caffeine and coffee. Effects on health and cardiovascular disease Comp. Biochem. Physiol. 109c:1994;173-189.
10. Chute D.L. Phosphodiesterase inhibition and memory facilitation. J Clin. Neuropsychol. 2:1980;72-74.
11. Coyle J.P., Puttfarchen P. Oxidative stress, glutamate and neurodegenerative disorders. Science. 262:1993;689-695.
12. DeNoble V.J., Repetti S.J., Gelpke L.W., Wood L.M., Keim K.L. Vinpocetine. Nootropic effects on scopolamine-induced and hypoxia-induced retrieval deficits of a step-through passive avoidance response in rats Pharmacol. Biochem. Behav. 24:1986;1123-1128.
13. D'Hellencourt C.L., Diaw L., Cornillet P., Guenounou M. Differential regulation of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline. Int. J. Immunopharmacol. 18:1996;739-748.
14. Donaldson A.M., Brown A.M., Hill S.J. Influence of rolipram on the cyclic 3′-5′-adenosine monophosphate response to histamine and adenosine in slices of guinea-pig cerebral cortex. Biochem. Pharmacol. 37:1988;715-723.
15. Fallahi N., Broad R.M., Jin S., Fredholm B.B. Release of adenosine from rat hippocampal slices by nitric oxide donors. J. Neurochem. 67:1996;186-193.
16. Goto M., Demura N., Sakaguchi T. Effects of propentofylline on disorder of learning and memory in rodents. Jpn. J. Pharmacol. 45:1987;373-378.
17. 1 adenosine receptor-adenylyl cyclase system in cerebellar granule cells. J. Neurochem. 67:1996;1921-1930.
18. Howell L.L., Coffin V.L., Spealman R.D. Behavioral and physiological effects of xanthines in nonhuman primates. Psychopharmacology (Berlin). 129:1997;1-14.
19. Hudlicka O., Komarek J., Wright A.J. The effect of a xanthine derivative, 1-(5-oxohexyl)-3-methyl-7-propylxanthine (HWA 285), on heart perfomance and regional blood flow in dogs and rabbits. Br. J. Pharmacol. 72:1981;723-730.
20. Imanishi T., Sawa A., Ichimaru Y., Miyashiro M., Kato S., Yamamoto T., Ueki S. Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents. Eur. J. Pharmacol. 321:1997;273-278.
21. Katchman A.N., Hershkowitz N. Early anoxia-induced vesicular glutamate release results from mobilization of calcium from intracellular stores. J. Neurophysiol. 67:1996;1921-1930.
22. Keller J.N., Hanni K.B., Mattson M.P., Markesbery W.R. Cyclic nucleotides attenuate lipid peroxidation-mediated neuron toxicity. Neuroreport. 9:1998;3731-3734.
23. Lancelot E., Lecanu L., Revaud M.L., Boulu R.G., Plotkine M., Callebert J. Glutamate induces hydroxyl radical formation in vivo via activation of nitric oxide synthase in Sprague-Dawley rats. Neurosci. Lett. 242:1998;131-134.
24. Morris R.G. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods. 11:1984;47-60.
25. Morris R.G., Garrud P., Rawlins J.N.P., O'Keefe J.O. Place navigation impaired in rats with hippocampal lesions. Nature. 297:1982;681-683.
26. O'Connolly M.O., Mayer M.-E.R., Wolf D., Brett M., Greb W.H. Efficacy and tolerance of denbrifylline (BRL 30892) in patients with cerebrovascular disease - An investigational study with a new agent. Krieglstein J. Pharmacology of cerebral ischemia. 1986;440 Elsevier, Amsterdam.
27. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 2nd ed:1986;Academic Press, Sydney.
28. Peredery O., Persinger M.A., Blomme C., Parker G. Absence of material behavior in rats with lithium/pilocarpine seizure induced brain damage. support of Macleans triune brain theory Physiol. Behav. 52:1992;665-671.
29. 2A receptor antagonists stimulate motor activity. Evidence for an increased effectiveness in aged rats Neurosci. Lett. 251:1998;201-204.
30. Schneider H.H. Brain cAMP response to phosphodiesterase inhibitors in rats killed by microwave irradiation or decapitation. Biochem. Pharmacol. 33:1984;1690-1693.
31. Sirin B.H., Yilik L., Coskun E., Ortac R., Sirin H. Pentoxyfylline reduces injury of the brain in transient ischaemia. Acta Cardiol. 53:1998;89-95.
32. Subhan Z., Hindmarch I. Psychopharmacological effects of vinpocetine in normal healthy volunteers. Eur. J. Clin. Pharmacol. 28:1985;567-571.
33. Sutherland R.J., Kolb B., Whishaw I.Q. Spatial mapping. Definitive disruption by hippocampal or medial frontal cortical damage in the rat Neurosci. Lett. 31:1982;271-276.
34. Swartbol P., Truedson L., Parson H., Norgren L. Tumor necrosis factor-alpha and interleukin-6 release from white blood cells induced by different graft materials in vitro are affected by pentoxifylline and iloprost. J. Biomed. Mater. Res. 36:1997;400-406.
35. Viana M.B., Tomaz C., Graeff F.G. The elevated T-maze. A new animal model of anxiety and memory Pharmacol. Biochem. Behav. 49:1994;549-554.
36. Whishaw I.Q. Hippocampal granule cell and CA3-4 lesions impair formation of a place learning set in the rat and induce reflex epilepsy. Behav. Brain Res. 24:1987;59-72.