Differential effects of the mixed ET(A)/ET(B)-receptor antagonist bosentan on endothelin-induced bronchoconstriction, vasoconstriction and prostacyclin release

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 362, Issue 2, 2000, Pages 128-136

  Martin, C ^a   Held, H D ^a   Uhlig, S ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Bosentan; Bronchoconstriction; Endothelin; IRL1620; Isolated perfused lung; Precision cut lung slices; Prostacyclin; Vasosonstriction

Indexed keywords

BOSENTAN; ENDOTHELIN 1; ENDOTHELIN 3; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR AGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; PROSTACYCLIN; SUCCINYLENDOTHELIN 1 [8-21][9 GLUTAMIC ACID 11,15 ALANINE];

ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; BRONCHOSPASM; BRONCHUS; CONCENTRATION RESPONSE; DRUG EFFECT; FEMALE; ISOLATED LUNG; NONHUMAN; RAT; VASOCONSTRICTION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; AREA UNDER CURVE; BRONCHOCONSTRICTION; ENDOTHELIN-1; ENDOTHELIN-3; ENDOTHELINS; EPOPROSTENOL; FEMALE; IMAGE PROCESSING, COMPUTER-ASSISTED; LUNG; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; RESPIRATORY MECHANICS; SULFONAMIDES; VASOCONSTRICTION;

EID: 0033874317     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000264     Document Type: Article

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