Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL1620 in the ileum

Journal of Cardiovascular Pharmacology

Volumn 31, Issue SUPPL. 1, 1998, Pages

  Miasiro, N ^a   Karaki, H ^b   Paiva, A C M ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Endothelin receptor subtypes; Ileum (guinea pig); IRL1620; Sarafotoxin S6c; Tachyphylaxis

Indexed keywords

APAMIN; ENDOTHELIN; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR; PEPTIDE FRAGMENT; SARAFOTOXINS S6; SUCCINYLENDOTHELIN 1 [8-21][9 GLUTAMIC ACID 11,15 ALANINE]; VASOCONSTRICTOR AGENT; VIPER VENOM;

ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; GUINEA PIG; ILEUM; IN VITRO STUDY; MUSCLE CONTRACTION; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; SMOOTH MUSCLE;

ANIMALS; APAMIN; ENDOTHELINS; GUINEA PIGS; ILEUM; ISOMETRIC CONTRACTION; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; PEPTIDE FRAGMENTS; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; VASOCONSTRICTOR AGENTS; VIPER VENOMS;

EID: 0000810162     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199800001-00050     Document Type: Article

References (7)

1. Masaki T, Vane JR, Vanhoutte PM. International Union of Pharmacology nomenclature of endothelin receptors. Pharmacol Rev 1994;46:137-42.
2. Shyamala V, Moulthrop THM, Stratton-Thomas J, et al. Two distinct endothelin B receptors generated by alternative splicing from a single gene. Cell Mol Biol Res 1994;40:285-96.
3. B receptor antagonist. Cardiovasc Drug Rev 1996;14:17-35.
4. Miasiro N, Karaki H, Paiva ACM. Heterogenous endothelin receptors mediate relaxation and contraction in the guinea-pig ileum. Eur J Pharmacol 1995;285:247-54.
5. Miasiro N, de Castiglione R, Paiva ACM. Role of positions 9 and 10 in the endothelin molecule for biological activity and discrimination of receptor subtypes. Eur J Pharmacol 1995;278:103-9.
6. Miasiro N, Nakaie CR, Paiva ACM. Endothelin (16-21): biphasic effect and no desensitization on the guinea-pig isolated ileum. Br J Pharmacol 1993;109:68-72.
7. + channels. Eur J Pharmacol 1992;219:355-60.