rIL-2-stimulated splenocytes reactivate the NO2-producing ability of macrophages infected by Leishmania Donovani

Immunopharmacology and Immunotoxicology

Volumn 22, Issue 3, 2000, Pages 465-487

  Eslami, Z ^a   Tanner, C E ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARASITIC AGENT; HYDROGEN PEROXIDE; NITRIC OXIDE; OXYGEN RADICAL; RECOMBINANT INTERLEUKIN 2; STIBOGLUCONATE SODIUM;

ANIMAL CELL; ARTICLE; DRUG EFFECT; DRUG MECHANISM; FEMALE; HOST; LEISHMANIA DONOVANI; MACROPHAGE ACTIVATION; MOUSE; MOUSE STRAIN; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALIA; LEISHMANIA DONOVANI; PROTOZOA;

EID: 0033868798     PISSN: 08923973     EISSN: None     Source Type: Journal    
DOI: 10.3109/08923970009026006     Document Type: Article

References (47)

1. The Immunobiology of visceral leishmaniasis
2. The structure and function of monocytes and macrophages
3. Monocytes and macrophages: Function and disease
4. Degradation of microorganisms by phagocytic cells
5. Selective inability of spleen antigen presenting cells from Leishmania donovani infected hamsters to mediate T ceil proliferation to parasite antigens
6. Secretory products of macrophages
7. Killing of intracellular Leishmania donovoni by human mononuclear phagocytes. Eviedence for oxygen-dependent and independent leishmanicidal activity
8. R, Failure of phagocytic oxidative response to protect human m6nocyte derived macrophages from infection by Leishmania donovani
9. R, Inhibition of N-fonnyl-methyonyl-leucyl-phenylalanine-induced stimnlus response coupling with monocytes infected with Leishmania: Evidence for a defect in agonist-induced calcium release
10. R, Defective stimulus-response coupling in human monocytes infected with Leishmania donovani is associated with altered activation in protein kinease c
11. -2 by protozoan parasites
12. R, L-arginine is required for expression of the activaed macrophage effector mechanism causing selective metabolic inhibition in target cells
13. Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: Precursors and role of the respiratory burst
14. J, Release of reactive nitrogen intermediates and reactive oxygen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages
15. Non specific defence mechanism: The role of nitric oxide
16. Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism
17. Tumor necrosis factor (TNF-α)in leishmaniasis. II. TNF-α induced macrophage leishmanicidal activity is mediated by nitric oxide from L- arginine
18. Role of inorganic nitrogen oxidase and tumor necrosis factor alpha in killing Leishmania donovani amastigotes in gmma-interferon-lipopolysaccharide-activated macrophages from Lsh(s) and Lsh(R)' mouse strains
19. Immunotherapy with IL-2-stimulated splenocytes reduces in vitro level of Leishmania donovani infection in peritoneal macrophages
20. IL-2-stimulated splenocytes reduce infections by Leishmania donovani in vivo
21. Synergism of IL-2-stimulated spleen cells and Pentostam enhances the killing of Leishmania donovani in vitro
22. Time course and intensity of infection in vitro in the resident peritoneal macrophages of resistant and susceptible mice exposed to different doses of Leishmania donovani promastigotes
23. Selected Methods in Cellular Immunology
24. Visceral leishmaniasis in congenic mice of susceptible and resistant phenotypes: Immunosuppression by adherent spleen cells
25. A simple method for the measurement of hydrogen peroxide produced by the cell culture
26. Increased superoxide anion production by immunologically activated and chemically elicited macrophages
27. A modified colorometric assay of macrophage activation for intracellular cytotoxicity against Leishmania parasites
28. Qantitative release of live microorganisms from infected macrophages by sodium dodecyl sulphate
29. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
30. An improved colorimetric assay for interleukine 2
31. SigmaStat: Statistical software for working scientists
32. Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role of synthesis of inorganic nitogen oxides from L-arginine
33. Tumor necrosis factor and granulocyte macrophage-colony stimulating factor stimulate human macrophages to restrict growth of virulent Mycobacterium avium and to kill M. avium: Killing effector mechanisms depends on the generation of reactive nitrogen intermediates
34. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production
35. Synthesis of nitrite and nitrate in murine macrophage cell lines
36. Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages
37. Experimental visceral leishmaniasis: Production of interlukine 2 and interferon-gamma, tissue immune reaction and response to treatment with interlukine 2 and interferon- gamma
38. Differential survival of Leishmania donovani amastigotes in human monocytes
39. Susceptibility of Leishmania to oxygen intermediates and killing by normal macrophages
40. Oxygen-dependent microbial systems of phagocytes and host defence against intracellular protozoa
41. Cell-mediated immune response in experimental visceral leishmaniasis. II. Oxygen-dependent killing o f intracellular Leishmania donovani amastigotes
42. Intracellular antimicrobial activity in the absence of IFN-γ. Effect of interlukine 12 in experimental visceral leishmaniasis in interferon-γ gene disrupted mice
43. Immunosuppression in Kenyan visceral leishmaniasis
44. Suppression of lymphocyte proliferation responses by sera from patients with American visceral leishmaniasis
45. A soluble factor produced by inoculation of human monocytes with Leishmania donovani promastigotes suppresses IFN-γdependent monocyte activation
46. Immunoregulation of genetically acquired responses to Leishmania donovani infection in mice: Demonstration and characterization of suppressor cells in non-cure mice
47. Visceral leishmaniasis in congenic mice of resistant and susceptible phenotype: Immunosuppression by adherent spleen cells