Extract of Nippostrongylus brasiliensis stimulates polyclonal type-2 immunoglobulin response by inducing de novo class switch

Infection and Immunity

Volumn 68, Issue 9, 2000, Pages 4913-4922

  Ehigiator, H N ^a   Stadnyk, A W ^a   Lee, T D G ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNOGLOBULIN PRODUCTION; MOUSE; NIPPOSTRONGYLUS BRASILIENSIS; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; FEMALE; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN-13; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; NIPPOSTRONGYLUS;

EID: 0033862852     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.9.4913-4922.2000     Document Type: Article

References (76)

1. Th1 and Th2 cells and immunity to intestinal helminths
2. A critical role for IL-13 in resistance to intestinal nematode infection
3. Differences between IL-4Rα-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses
4. The polyclonal and antigen-specific IgE, IgG1 and IgG2a response of mice injected with ovalbumin in alum or complete freund's adjuvant
5. Synthesis of germ-line γ1 immunoglobulin heavy-chain transcripts in resting B cells: Induction by interleukin 4 and inhibition by interferon γ
6. Quantitation of immunoglobulin μ-γ1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method
7. DNA rearrangement can account for in vitro switching to IgG1
8. Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production
9. Differential effects of retinoids on pokeweed mitogen induced B ceil proliferation versus immunoglobulin synthesis
10. Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13
11. CD40 signaling induces interleukin-4-independent IgE switching in vivo
12. Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B cell stimulatory factor-1
13. IL-4 is required to generate and sustain in vivo IgE responses
14. Regulation of murine in vivo IgG and IgE responses by a monoclonal anti-IL-4 receptor antibody
15. Cytokine regulation of host defence against parasitic gastrointestinal nematodes: Lessons from studies with rodent models
16. IL-4 plus CD40 monoclonal antibody induces human B cells γ subclass-specific isotype switch: Switching to γ1, γ3, and γ4, but not γ2
17. Production of an interferon-gamma homologue by an intestinal nematode: Functionally significant or interesting artefact?
18. Isolation of high-molecular-weight DNA from mammalian cells
19. Early cytokine responses during intestinal parasitic infections
20. Time course studies on rat IgE production in N. brasiliensis infection
21. Production and activities of IgE in helminth infection
22. Induction of an IgE response by Nippostrongylus brasiliensis: Characterization of lymphoid cells with intracytoplasmic or surface IgE
23. IL-4 induces the specific rearrangement of γ1 genes on the expressed and unexpressed chromosomes of lipopolysaccharide-activated normal murine B cells
24. Effect of Nippostrongylus brasiliensis infection on anti-hapten IgE antibody response in the mouse. I. Induction of carrier specific helper cells
25. Disruption of the murine IL-4 gene blocks Th2 cytokine responses
26. Generation and analysis of interleukin-4 deficient mice
27. Mouse IL-13 enhances antibody production in vivo and acts directly on B cells in vitro to increase survival and hence antibody production
28. Nippostrongylus brasiliensis: Cytokine responses and worm expulsion in normal and IL-4 deficient mice
29. Concomitant immunoglobulin E and immunoglobulin G1 formation in Nippostrongylus brasiliensis-infected mice
30. Prolongation of rat kidney allograft survival by nematodes
31. Potentiation of IgE responses to third party antigens mediated by Ascaris suum soluble products
32. Polyclonal stimulation of murine B lymphocytes by Ascaris soluble product
33. Nematode infection enhances survival of activated T cells by modulating accessory cell function
34. Cholera toxin promotes B cell isotype differentiation
35. Cholera toxin acts synergistically with IL-4 to promote IgG1 switch differentiation
36. Immunological modulation and evasion by helminth parasites in human populations
37. Interleukin 5 induces Sμ-Sγ1 DNA rearrangement in B cells activated with dextran-anti-IgD antibodies and interleukin 4: A three-component model for Ig class switching
38. IL-4 induction of IgE class switching by lipopolysaccharide-activated murine B cells occurs predominantly through sequential switching
39. Cytokine mRNA expression profiles in rats infected with the intestinal nematode Nippostrongylus brasiliensis
40. Impaired development of Th2 cells in IL-13-deficient mice
41. Simultaneous disruption of interleukin (IL)-4 and IL-13 defined individual roles in T helper cell type 2-mediated responses
42. Molecular mechanisms controlling immunoglobulin E responses
43. Ig μ-ε isotype switch in IL-4-treated human B lymphoblastoid cells: Evidence for a sequential switch
44. Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse
45. IL-2 inhibits IL-4-dependent IgE and IgG1 production in vitro and in vivo
46. Adoptive transfer of total and parasite-specific IgE responses in rats infected with Nippostrongylus brasiliensis
47. Potentiated reagin response to egg albumin in Nippostrongylus brasiliensis infected rats. II. Time course of the reagin response
48. Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor
49. Induction of murine T-helper-cell responses to the filarial nematode Brugia malayi
50. IL-12 modulation of T helper responses to the filarial helminth, Brugia malayi
51. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells
52. Independent regulation of DNA recombination and immunoglobulin (Ig) secretion during isotype switching to IgG1 and IgE
53. Defence against the immune barrage: Heiminth survival strategies
54. Adult worm homogenate of the nematode parasite Heligmosomoides polygyrus induces proliferation of naive T lymphocytes without MHC restriction
55. Heligmosomoides polygyrus adult worm homogenate superantigen: Presentation to T cells requires MHC class I positive accessory cells
56. In vitro stimulation of naive mouse lymphocytes by Heligmosomoides polygyrus adult worm antigens induces the production of IgG1
57. Mitogen plus interleukin 4 induction of Cε transcript in B lymphoid cells
58. IL-10 selectively regulates murine Ig isotype switching
59. The murine IgG1/IgE class switch program
60. B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching
61. B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germ-line C(H) transcription, and Ig class switching
62. The role of interleukin-4 in IgE and IgG subclass formation
63. Antibody class switching
64. Preparation of genomic DNA from mammalian tissue
65. IgE and IgG1 production by a soluble product of Ascaris suum in the guinea-pig
66. Antigen dose-dependent predominance of either direct or sequential switch in IgE antibody responses
67. A primary intestinal helminth infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3
68. IgE antibody responses induced by transplantation of the nematode Nippostrongylus brasiliensis in rats: A possible role of nematode excretory-secretory product in IgE production
69. IgE antibody production is associated with suppressed interferon-γ levels in mesenteric lymph nodes of rats infected with the nematode Nippostrongylus brasiliensis
70. The cellular IgE response of rodents to infection with Nippostrongylus brasiliensis, Trichinella spiralis and Schistosoma mansoni
71. Intestinal immune responses of mammals to nematode parasites
72. IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
73. IFN-γ represses ε germline transcription and subsequently down regulates switch recombination to ε
74. Immunoglobulin switch circular DNA in the mouse infected with Nippostrongylus brasiliensis: Evidence for successive class switching from μ to ε via γ1
75. The IgE and IgG subclass responses of mice to four helminth parasites
76. B cells genetically deficient in the c-Rel transactivation domain have selective defects in germline C(H) transcription and Ig class switching