Differences in time-related cardiopulmonary responses to hypoxia in three rat strains

Clinical and Experimental Hypertension

Volumn 22, Issue 5, 2000, Pages 471-492

  Bochnowicz, Steven ^b   Osborn, Ruth R ^b   Luttmann, Mark A ^b   Louden, Calvert ^a   Hart, Tim ^a   Hay, Douglas W P ^b   Underwood, David C ^b  

^a Depts Pulmon Pharmacol Safety A   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Endothelin 1; High altitude sensitive; Hypoxia; Pulmonary hypertension; Rat lung; Right ventricular hypertrophy; Sprague Dawley; Vascular remodeling; Wistar

Indexed keywords

CARBACHOL; ENDOTHELIN 1; METHACHOLINE;

ALTITUDE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXIA; IN VITRO STUDY; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; MALE; NONHUMAN; PULMONARY HYPERTENSION; RAT;

ALTITUDE; ANIMALS; ANOXIA; CARBACHOL; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; ENDOTHELINS; HYPERTENSION, PULMONARY; HYPERTROPHY; HYPERTROPHY, RIGHT VENTRICULAR; MALE; METHACHOLINE CHLORIDE; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SPECIES SPECIFICITY; TRACHEA; VASOCONSTRICTION; VASODILATION;

EID: 0033862101     PISSN: 10641963     EISSN: None     Source Type: Journal    
DOI: 10.1081/CEH-100100085     Document Type: Article

References (33)

1. 3H-thymidine by cells of the rat pulmonary arteries and alveolar wall. Am J Pathol 1979; 96: 51-70
2. Rabinovitch, M, Konstam, MA, Gamble, WJ, Papanicolaou, N, Aronovitch, MJ, Treves, S, Reid, L. Changes in pulmonary blood flow affect vascular response to chronic hypoxia in rats. Circ Res 1983; 52: 432-441
3. Abraham, AS, Kay, JM, Cole, RB, Pincock, AC. Haemodynamic and pathological study of the effect of chronic hypoxia and subsequent recovery of the heart and pulmonary vasculature of the rat. Cardiovasc Res 1971; 5: 95-102
4. Rabinovitch, M, Gamble, W, Nadas, AS, Miettinen, OS, Reid, L. Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Am J Physiol 1979; 236: H818-H827
5. Hunter, C, Barer, GR, Shaw, JW, Clegg EJ. Growth of the heart and lungs in hypoxic rodents: a model of human hypoxic disease. Clin Sci Molec Med 1974; 46: 375-391
6. James, WRL, Thomas, AJ. The effect of hypoxia on the heart and pulmonary arterioles of mice. Cardiovasc Res 1968; 3: 278-283
7. Janssens, SP, Thompson, BT, Spence, CR, Hales, CA. Polycythemia and vascular remodeling in chronic hypoxic pulmonary hypertension in guinea pigs. J Appl Physiol 1991; 71(6): 2218-2223
8. Thompson, BT, Hassoun, PM, Kradin, RL, Hales, CA. Acute and chronic hypoxic pulmonary hypertension in guinea pigs. Am J Physiol 1989; 66(2): 920-928
9. Bochnowicz, S, Osborn, RR, Hay, DWP, Underwood, DC. Hypoxia-induced pulmonary hypertension in an optimized environment for the guinea pig. Lab Animals 1997; 31: 347-356
10. Colice, GL, Hill, NS, Lee, YJ, Du, H, Klinger, JR, Leiter, JC, Ou, LC. Exaggerated pulmonary hypertension with monocrotaline in rats susceptible to chronic mountain sickness. J Appl Physiol 1997; 83(1): 25-31
11. Hill, NS, Ou, LC, Thron, CD, Smith, RP. Time course of cardiopulmonary responses to high altitude in susceptible and resistant rat strains. Respir Physiol 1987; 70: 241-249
12. Klinger, JR, Wren, DS, Warburton, RR, Pietras, L, Ou, LC, Hill, NS. Atrial natriuretic peptide expression in rats with different pulmonary hypertensive reponses to hypoxia. Am J Physiol 1997; 273: H411-H417
13. Ou, LC, Smith, RP. Probable strain differences of rats in susceptibilities and cardiopulmonary responses to chronic hypoxia. Respir Physiol 1983; 53: 367-377
14. Resta, TC, Walker, BR. Orally administered L-arginine does not alter right ventricular hypertrophy in chronically hypoxic rats. Am J Physiol 1994; 266: R559-R563
15. Jin, XR, Fan, M, Wang, ZQ, Yang, GT, Hu, HB, Zhang, YP, Feng, CJ, Ding, YX, Wang, DX. Strain differences in pulmonary vascular responsiveness to hypoxia in rats. J Tongji Med Univ 1990; 10: 134-140
16. Underwood, DC, Bochnowicz, S, Osborn, RR, Luttmann, MA, Hay, DWP. Nonpeptide endothelin receptor antagonists. X Inhibition of endothelin-1- and hypoxia-induced pulmonary pressor responses in the guinea pig by the endothelin receptor antagonist, SB 217242. J Pharmacol Exp Ther 1997; 283: 1130-1137
17. Fulton, RM, Hutchinson, EC, Jones, AM. Ventricular weight in cardiac hypertrophy. British Heart J 1952; 14: 413-120
18. Rabinovitch M. Elastase and cell matrix interactions in the pathobiology of vascular disease. Acta Paediatrica Japonica 1995; 37: 657-666
19. MacLean, MR, McCulloch, KM, Baird, M. Effects of pulmonary hypertension on vasoconstriction responses to endothelin-1 and sarofotoxin s6c and on inherent tone in rat pulmonary arteries. J Cardiovasc Pharmacol 1995; 26: 822-830
20. Adnot, S, Raffestin, B, Eddahibi, S, Braquet, P, Chabrier, PE. Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J Clin Invest 1991; 87(1): 155-162
21. Feletou, M, Girard, V, Canet, E. Different involvement of nitric oxide in endothelium-dependent relaxation of porcine pulmonary artery and vein: influence of hypoxia. J Cardiovasc Pharmacol 1995; 25(4): 665-673
22. Kourembanas, S, McQuillan, LP, Leung, GK, Faller, DV. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J Clin Invest 1993; 92(1): 99-104
23. Ryan, US, Zhong, R, Hates, BA, Visner, G, Sauther, ML . Regulation of endothelin-1 expression in normal and transfected endothelial cells. J Cardiovas Pharmacol 1993; 22(8): S38-S41
24. Giaid, A, Yanagisawa, M, Langleben, D, Michel, RP, Levy, R, Shennib, H, et al. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. New Eng J Med 1993; 328: 1732-1739
25. Goligorsky, MS, Tsukahara, H, Magazine, H, Andersen, TT, Malik, AB, Bahou, WF. Termination of endothelin signaling: role of nitric oxide. J Cell Physiol 1994; 158(3): 485-494
26. Voelkel NF, Tuder, RM, Wade, K, Hoper, M. Lepely, RA, Goulet, JL, Koller, BH, Fitzpatrick, F. Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. J Clin Invest 1996; 97: 2491-2498
27. Vyas-somani AC, Aziz, SM, Arcot, SA, Gillespie, MN, Olson, JW, Lipke, DW. Temporal alterations in basement membrane components in the pulmonary vasculature of chronically hypoxic rat: Impact of hypoxia and recovery. Am J Med Sci 1996; 312: 54-67
28. Aulakh, CS, Tolliver, T, Wozniak, KM, Hill, JL, Murphy, DL. Functional and biochemical evidence for altered serotonergic function in the fawn-hooded rat strain. Pharmacol Biochem Behav 1994; 49: 615-620
29. Shore S, Kobzik, NC, Long, W, Skornik, CJ, Van Staden, L, Boulet, Rodger, IA, Pon DJ. Increased airway responsiveness to inhaled methacholine in a rat model of chronic bronchitis. Am J Respir Crit Care Med 1996; 151: 1931-1938
30. He, LS, Chang, SW, Voelkel, NF. Pulmonary vascular reactivity in Fischer rats. J Appl Physiol 1991; 70: 1861-1866
31. Kentara, D, Susic, D, Veljkovic, V, Tukacovic, G, Koko V. Pulmonary artery pressure in rats with hereditary platelet function defect. Respiration 1988; 54: 110-114
32. Sato, K, Tucker, A, O'Brien, RF, McMurtry, IF, Stelzner, TJ. Factors influencing the spontaneous development of pulmonary hypertension in fawn-hooded rats. Am Rev Respir Dis 1992; 145: 793-797
33. Zamora, MR, Stelzner, TJ, Webb, S, Panos, RJ, Ruff, LJ, Dempsey, EC. Overexpression of endothelin-1 and enhanced growth of pulmonary artery smooth muscle cells from fawn-hooded rats. Am J Physiol 1996; 270: L101-L109