Caspase-dependent and independent cell death in rat hepatoma 5123tc cells

Apoptosis

Volumn 5, Issue 3, 2000, Pages 265-275

  Pandey, S ^a   Smith, B ^a   Walker, P R ^a   Sikorska, M ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Apoptosis; DNA fragmentation; Necrosis; Phosphorylation; Protease inhibitors

Indexed keywords

ASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE INHIBITOR; DNA FRAGMENT; GROWTH FACTOR; TENIPOSIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL SWELLING; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; HEPATOMA CELL; LIVER CELL CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CASPASES; CELL NUCLEUS; CULTURE MEDIA, SERUM-FREE; CYSTEINE PROTEINASE INHIBITORS; DNA FRAGMENTATION; ELECTROPHORESIS, GEL, PULSED-FIELD; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYME INHIBITORS; HUMANS; LAMINS; MICROSCOPY, FLUORESCENCE; NUCLEAR PROTEINS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; RATS; TENIPOSIDE; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0033860626     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009608630145     Document Type: Article

References (31)

1. Apoptosis: A basic phenomenon with wide ranging implications in tissue kinetics
2. Cell Death: A new classification separating apoptosis from necrosis
3. Caspases: Killer proteases
4. A caspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD
5. Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis
6. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
7. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
8. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme
9. Mice deficient in IL-1 beta converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock
10. Murine caspase-ll, an ICE interacting protease is essential for the activation of ICE
11. Defects in regulation of apoptosis in caspase-2 deficient mice
12. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
13. Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation
14. Neither caspase-3 nor DNA fragmentation factor are required for high molecular weight DNA degradation in apoptosis
15. Studies on the development, biochemistry, and biology of experimental hepatomas
16. Detection of the initial stages of DNA fragmentation in apoptosis
17. Detection of DNA fragmentation and endonucleases in apoptosis
18. Caspase-independent cell killing by Fas-associated protein with death domain
19. Hepatocytes sensitized to tumor necrosis factor cytotoxicity undergo apoptosis through caspase-dependent and caspase-independent pathways
20. Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution
21. Caspases: The executioners of apoptosis
22. Peptide inhibitor of ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro
23. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
24. Essential contribution of caspase-3/CPP32 to apoptosis and its associated nuclear changes
25. Bcl-xL acts downstream of caspase-8 activation by CD95 death-inducing signaling complex
26. Identification of a novel 97 kDa endonuclease capable of internucleosomal DNA cleavage
27. DNase Y.: A rat DNase I-like gene coding for a constitutively expressed chromatin-bound endonuclease
28. Apoptosis-related functional features of the Dnase-I like family of nucleases
29. z-VAD-fmk and DEVD-cho induced late mitosis arrest and apoptotic expressions
30. Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways
31. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation