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Volumn 28, Issue 8, 2000, Pages 912-919

Ontogeny of valproic acid disposition and metabolism: A developmental study in postnatal lambs and adult sheep

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; VALERIC ACID; VALPROIC ACID;

EID: 0033856078     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (11)

References (36)
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  • 4
    • 0242497635 scopus 로고
    • Age-related changes in fatty acid oxidation, in Idiosyncratic Reactions to Valproate: Clinical Risk Patterns and Mechanisms of Toxicity (Levy RH and Penry JK eds) Raven Press, New York
    • (1991) , pp. 13-18
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  • 16
    • 0027412659 scopus 로고
    • Cytochrome P-450-mediated dehydrogenation of 2-n-propyl-2(E)-pentenoic acid, a pharmacologically active metabolite of valproic acid, in rat liver microsomal preparations
    • (1993) Drug Metab Dispos , vol.21 , pp. 242-248
    • Kasshun, K.1    Baillie, T.A.2
  • 19
    • 0008391678 scopus 로고    scopus 로고
    • Drug disposition in the maternal-fetal unit: Studies with diphenhydramine and valproic acid in pregnant sheep
    • Ph.D. Thesis, University of British Columbia, Vancouver, B.C., Canada
    • (1998)
    • Kumar, S.1
  • 22
    • 0002721046 scopus 로고
    • Valproic acid: Absorption, distribution and excretion
    • 4th ed. (Levy RH, Mattson RH and Meldrum BS eds) Raven Press Ltd., New York
    • (1995) Antiepileptic Drugs , pp. 605-619
    • Levy, R.H.1    Shen, D.2
  • 24
    • 0021638232 scopus 로고
    • Valproic acid and metabolites: Pharmacological and toxicological studies
    • (1984) Epilepsia , vol.25 , Issue.SUPPL. 1
    • Nau, H.1    Loscher, W.2
  • 25
    • 0003061556 scopus 로고
    • Valproic acid metabolite patterns in 195 children with epilepsy: Effect of age, dose, comedication, duration of treatment, and clinical factors, in Idosyncratic Reactions to Valproate Clinical Risk Patterns and Mechanisms of Toxicity (Levy RH and Penry JK eds) Raven Press Ltd., New York
    • (1991) , pp. 65-74
    • Nau, H.1    Siemes, H.2    Fischer, E.3    Pund, R.4    Wittfoht, W.5    Drews, E.6
  • 27
    • 0000446685 scopus 로고    scopus 로고
    • Valproate in the treatment of epilepsies in children
    • (Loscher W ed) Birkhauser Verlag, Basel, Switzerland
    • (1999) Valproate , pp. 131-151
    • Sarisjulis, N.1    Oliver, D.2
  • 31
    • 0029974584 scopus 로고    scopus 로고
    • Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl- 2,4-pentadienoic acid, via glucuronidation: LC/MS/MS characterization of the GSH-glucuronide diconjugates
    • (1996) Chem Res Toxicol , vol.9 , pp. 517-526
    • Tang, W.1    Abbott, F.S.2
  • 34
    • 0026587342 scopus 로고
    • Dose dependent inhibition in plasma protein binding of valproic acid during continued treatment in guinea pigs
    • (1992) J Pharm Pharmacol , vol.44 , pp. 408-412
    • Yu, H.Y.1    Shen, Y.Z.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.