Metabolite profiles in patients on high-dose valproate monotherapy

Epilepsy Research

Volumn 25, Issue 2, 1996, Pages 107-112

  Sugimoto, Tateo ^a   Muro, Hideki ^b   Woo, Man ^a   Nishida, Naoki ^a   Murakami, Kiyotaka ^c  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b Moji Rousai Hospital   (Japan)

^c Nakano Children's Hospital   (Japan)

Author keywords

4 en Valproate; Hepatotoxicity; Valproate; Oxidation; Oxidation

Indexed keywords

VALPROIC ACID; VALPROIC ACID DERIVATIVE;

ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; EPILEPSY; FEMALE; HUMAN; MALE; PRIORITY JOURNAL;

EID: 0030272650     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/0920-1211(96)00019-8     Document Type: Article

References (22)

1. [1] Anderson, G.D., Acheampong, A.A., Wilensky, A.J. and Levy, R.H., Effect of valproate dose on formation of hepatotoxic metabolites, Epilepsia, 33 (1992) 736-742.
2. [2] Dreifuss, F.E., Santiui, N., Langer, D.H., Sweeney, K.P., Moline, K.A. and Menander, K.B., Valproic acid hepatic fatalities: a retrospective review, Neurology, 37 (1987) 379-385.
3. [3] Fisher, E., Siemes, H., Pund, R., Wittfoht, W. and Nau, H., Valproate metabolites in serum and urine during antiepileptic therapy in children with infantile spasms: abnormal metabolite pattern associated with reversible hepatotoxicity, Epilepsia, 33 (1992) 165-171.
4. [4] Gerber, N., Dickinson, R.G., Harland, R.C., Lynn, R.K., Houghton, D., Antonias, J.I. and Schmschock, J.C., Reye-like syndrome associated with valproic acid therapy, J. Pediatr., 95 (1979) 142-144.
5. [5] Hurst, D.L., Expanded therapeutic range of valproate, Pediatr. Neurol., 3 (1987) 342-344.
6. [6] Kochen, W., Schneider, A. and Ritz, A., Abnormal metabolism of valproic acid in fatal hepatic failure, Eur. J. Pediatr., 141 (1983) 30-35.
7. [7] Kondo, T., Kaneko, S., Otani, K., Ishida, M., Hirano, T. and Fukushima, Y., Association between risk factors for valproate hepatotoxicity and altered valproate metabolism, Epilepsia, 33 (1992) 172-177.
8. [8] König, S.A., Siemes, H., Blaker, F., Boenigk, E., Gross-Selbeck, G., Hanefeld, F., Haas, N., Koler, B., Koelfen, W., Korinthenberg, R., Kurek, E., Lenard, H.-G., Penin, H., Penzien, J.M., Schunke, C., Schultze, C., Stephani, U., Stute, M., Traus, M., Wienmann, H.-M. and Scheffner, D., Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities, Epilepsia, 35 (1994) 1005-1015.
9. [9] Kuhara, T., Inoue, Y., Matsumoto, M., Shinka, T., Matsumoto, I. and Kawahara, N., Markedly increased ω-oxidation of valproate in fulminant hepatic failure, Epilepsia, 31 (1990) 214-217.
10. [10] Murakami, K., Sugimoto, T., Nishida, N., Kobayashi, Y., Kuhara, T. and Matsumoto, I., Abnormal metabolism of carnitine and valproate in a case of acute encephalopathy during chronic valproate therapy, Brain Dev., 14 (1992) 178-181.
11. [11] Nishida, N., Sugimoto, T., Araki, A., Woo, M., Sakane, Y. and Kobayashi, Y., Carnitine metabolism in valproate-treated rats: the effect of L-carnitine supplementation, Pediatr. Res., 22 (1987) 500-503.
12. [12] Ohtsuka, Y., Amano, R., Mizukawa, M., Oka, E. and Ohtawara, S., Treatment of intractable childhood epilepsy with high-dose valproate, Epilepsia, 33 (1992) 158-164.
13. [13] Siemes, H., Spohr, H.L., Michael, T. and Nau, H., Therapy of infantile spasms with valproate: results of a prospective study, Epilepsia, 29 (1988) 553-560.
14. [14] Siemes, H., Nau, H., Schultze, K., Wittfoht, W., Drews, E., Penzien, J. and Seidel, U., Valproate (VPA) metabolites in various clinical conditions of probable VPA-associated hepatotoxicity, Epilepsia, 34 (1993) 332-346.
15. [15] Sugimoto, T., Nishida, N., Yasuhara, A., Ono, A., Sakane, Y. and Matsumura, T., Reye-like syndrome associated with valproic acid, Brain Dev., 5 (1983) 334-337.
16. [16] Sugimoto, T., Woo, M., Nishida, N., Takeuchi, T., Sakane, Y. and Kobayashi, Y., Hepatotoxicity in rat following administration of valproic acid, Epilepsia, 28 (1986) 142-146.
17. [17] Sugimoto, T., Araki, A., Nishida, N., Sakane, Y., Woo, M., Takeuchi, T. and Kobayashi, Y., Hepatotoxicity in rat following administration of valproic acid: effect of L-carnitine supplementation, Epilepsia, 28 (1986) 373-377.
18. [18] Tatsuhara, T., Muro, H., Matsuda, Y. and Imai, Y., Determination of valproic acid and its metabolites by gas chromatography-mass spectrometry with selected ion monitoring, J. Chromatogr., 399 (1987) 183-195.
19. [19] Tennison, M.B., Miles, M.V., Pollack, G.M., Thorn, M.D. and Dupuis, R.E., Valproate metabolites and hepatotoxicity in an epileptic population, Epilepsia, 29 (1988) 543-547.
20. [20] Thurston, J.H. and Hauhart, R.E., Amelioration of adverse effects of valproic acid on ketogenesis and liver coenzyme A metabolism by co-treatment with pantothenate and carnitine in developing mice: possible clinical significance, Pediatr. Res., 31 (1992) 419-423.
21. [21] Woo, M., Sugimoto, T., Nishida, N., Sasaki, T., Murakami, K., Yasuhara, A., Araki, A. and Kobayashi, Y., Valproate retard granule: efficacy and side effect, Jpn. J. Psychiat. Neurol., 47 (1993) 288-290.
22. [22] Zimmerman, H.J. and Ishak, K.G., Valproate-induced hepatic injury: analysis of 23 fatal cases, Hepatology, 2 (1982) 591-597.