The Gln-Arg191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated with the risk of coronary artery disease in Finns

Journal of Clinical Investigation

Volumn 98, Issue 4, 1996, Pages 883-885

  Antikainen, Marjatta ^a,b   Murtomäki, Sanna ^a   Syvänne, Mikko ^c   Pahlman, Raija ^a   Tahvanainen, Esa ^a   Jauhiainen, Matti ^a   Frick, M Heikki ^c   Ehnholm, Christian ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

atherosclerosis; coronary artery disease; gene, polymorphism; paraoxonase

Indexed keywords

ARYLESTERASE; DNA;

ADULT; AGED; ALLELISM; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0029788728     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118869     Document Type: Article

References (13)

1. Humbert, R., D.A. Adler, C.M. Disteche, C. Hassett, C.J. Omiecinski, and C.E. Furlong. 1993. The molecular basis of the human serum paraoxonase activity polymorphism. Nature Genet. 3:73-76.
2. Adkins, S., K.N. Gan, M. Mody, and B.N. La Du. 1993. Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes. Am. J. Hum. Genet. 52:598-608.
3. La Du, B.N. 1992. Human serum paraoxonase/arylesterase. In Pharmacogenetics of Drug Metabolism. W. Kalow, editor. Pergamon Press, New York. 51-91.
4. Mackness, M.I. 1989. 'A'-esterases - enzymes looking for a role? Biochem. Pharmacol. 38:385-390.
5. Ruiz, J., H., Blanche, R.E. James, M-C.B. Garin, C. Vaisse, G. Charpentier, N. Cohen, A. Morabia, P. Passa, and P. Froguel. 1995. Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes. Lancet. 346:869-872.
6. Serrato, M., and A.J. Marian. 1995. A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease. J. Clin. Invest. 96:3005-3008.
7. Syvänne, M., M.S. Nieminen, M.-R. Taskinen, and M.H. Frick. 1994. An angiographic secondary prevention trial with gemfibrozil in post-bypass men with low plasma HDL-C concentrations: study design and baseline characteristics. Atherosclerosis. 100:153-154 (Abstr.)
8. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. Cold Spring Laboratory Press, New York.
9. Syvänen, A.C., A. Sajantila, and M. Lukka. 1993. Identification of individuals by analysis of biallelic DNA markers, using PCR and solid-phase minisequencing. Am. J. Hum. Genet. 52:46-59.
10. Norman, G.R., and D.L. Steiner. 1994. Biostatics. The bare essentials. Mosby-Year Book, St. Louis, Missori. 260 pp.
11. Nevanlinna, H. 1972. The Finnish population structure. A genetic and genealogical study. Hereditas. 71:195-236.
12. Hegele, R.A., J.H. Brunt, and P.W. Connelly. 1995. A polymorphism of the paraoxonase gene associated with variation in plasma lipoproteins in a genetic isolate. Arterioscler. Thromb. Vasc. Biol. 15:89-95.
13. Watson, A.D., J.A. Berliner, S.Y. Hama, B.N. La Du, K.F. Fauli, A.M. Fogelman, and M. Navab. 1995. Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein. J. Clin. Invest. 96:2882-2891.