Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 7, 1997, Pages 2257-2260

  Odawara, Masato ^a,b   Tachi, Yoichi ^a   Yamashita, Kamejiro ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ARYLESTERASE; DNA; GLUTAMINE; HIGH DENSITY LIPOPROTEIN; LIPID PEROXIDE; LOW DENSITY LIPOPROTEIN; ARYLDIALKYLPHOSPHATASE; ESTERASE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENOTYPE; HUMAN; ISCHEMIC HEART DISEASE; JAPAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; CORONARY ARTERY DISEASE; GENETIC POLYMORPHISM; GENETICS; MIDDLE AGED;

ADULT; AGED; AGED, 80 AND OVER; ARYLDIALKYLPHOSPHATASE; CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; ESTERASES; FEMALE; HUMANS; JAPAN; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 85047677146     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.82.7.4096     Document Type: Article

References (19)

1. Stamler J, Vaccaro O, Neaton JD, Wentworth D, for the Multiple Risk Factor Intervention Trial Research Group. 1993 Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care. 16:434-444.
2. Tas S. 1991 Genetic predisposition to coronary heart disease and gene for apolipoprotein-CIII. Lancet. 337:113-114.
3. Ukkola O, Savolainen MJ, Salmela PI, von-Dickhoff K, Kesaniemi YA. 1995 DNA polymorphisms at the lipoprotein lipase gene are associated with macroangiopathy in type 2 (non-insulin-dependent) diabetes mellitus. Atherosclerosis. 115:99-105.
4. Steinberg D, Witzum JL. 1990 Lipoproteins and atherogenesis. JAMA. 264:3047-52.
5. Watson AD, Navab M, Hough GP, et al. 1994 Biologically active phospholipids in MM-LDL are transferred to HDL and are hydrolysed by HDL-associated esterases. Circulation. [Suppl] 90:1-353.
6. Mackness MI, Arrol S, Abbott CA, and Durrington PN. 1993 Is paraoxonase related to atherosclerosis. Chem Biol Interactions. 87:161-171.
7. Mackness MI, Arrol S, and Durrington PN. 1991 Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett. 286:152-154.
8. Blatter M-C, James RW, Messmer S, Barja F, Pometta D. 1993 Identification of a distinct high-density lipoprotein subspecies defined by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase. Eur J Biochem. 211:871-879.
9. McElveen J, Mackness MI, Colley CM, Peard T, Warner S, Walker CH. 1986 Distribution of paraoxon hydrolysing activity in the serum of patients after myocardial infarction. Clin Chem. 32:671-673.
10. Adkins S, Gan KN, Mody Malay, La Du BN. 1993 Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: Glutamine or arginine at position 191, for the respective A or B allozymes. Am J Hum Genet. 52:598-608.
11. Humbert RD, Adler A, Disteche CK, Hassett C, Omiecinski CJ, Furrlong CE. 1993 The molecular basis of the human serum paraoxonase activity polymorphism. Nat Genet. 3:73-76.
12. Furlong CE, Costa LG, Hassett C, Richter RJ, Sundstrom JA, Adler DA, Disteche CM, Omieeinski CJ, Chapline C, Crabb JW, Humbert R. 1993 Human and rabbit paraoxonases: Cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification. Chem Biol Interactions. 87:35-48.
13. 192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes. Lancet. 346:869-872.
14. 191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated the risk of coronary artery disease in Finns. J Clin Invest. 98:883-885.
15. World Health Organization. 1985 Diabetes Mellitus. Report of the WHO Study Group. WHO Tech Rep Ser. 727:1-113.
16. Sambrook J, Fritsch EF, Maniatis T. 1989 Molecular Cloning: a laboratory manual. New York: Cold Spring Harbor Laboratory Press.
17. Hegele RA, Brunt JH, Connelly PW. 1995 A polymorphism of the paraoxonase gene associated with variation in plasma lipoproteins in a genetic isolate. Arterioscler Thromb Vasc Biol. 15:89-95.
18. Serrato M, Marian AJ. 1995 A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease. J Clin Invest. 96:3005-3008.
19. Sanghera DK, Saha N, Aston CE, Kamboh MI. 1996 Genetic polymorphism of paraoxonase and the risk of coronary heart disease. Am J Hum Genet. [Suppl A] 59:188-1074.