Loss control of Mcm5 interaction with chromatin in cdc6-1 mutated in CDC-NTP motif

DNA and Cell Biology

Volumn 19, Issue 7, 2000, Pages 447-457

  Feng, Luo ^a   Hu, Yu ^a   Wang, Bin ^a   Wu, Lingtao ^a   Jong, Ambrose ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMATIN; CONTROLLED STUDY; DNA REPLICATION; GENE CONTROL; GENE ISOLATION; GENE LOSS; GENE MUTATION; GENE STRUCTURE; GENETIC CONSERVATION; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE;

AMINO ACID SUBSTITUTION; BINDING SITES; CELL CYCLE PROTEINS; CHROMATIN; DNA, FUNGAL; DNA-BINDING PROTEINS; MUTATION; ORIGIN RECOGNITION COMPLEX; PROTEIN BINDING; REPLICATION ORIGIN; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES POMBE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 0033853131     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/10445490050085933     Document Type: Article

References (45)

1. Aparicio, O.M., Weinstein, D.M., and Bell, S.P. (1997). Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase. Cell 91, 59-69.
2. Baker, T.A., and Bell, S.P. (1998). Polymerases and the replisome: Machines within machines. Cell 92, 295-305.
3. Bell, S.P., Kobayashi, R., and Stillman, B. (1993). Yeast origin recognition complex functions in transcription silencing and DNA replication. Science 262, 1844-1849.
4. Bell, S.P., Mitchell, J., Leber, J., Kobayashi, R., and Stillman, B. (1995). The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing. Cell 83, 563-568.
5. Bell, S.P., and Stillman, B. (1992). ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357, 128-134.
6. Bueno, A., and Russell, P. (1992). Dual functions of CDC6: A yeast protein required for DNA replication also inhibits nuclear division. EMBO J. 11, 2167-2176.
7. Chong, J.P., Thommes, P., and Blow, J.J. (1996). The role of MCM/P1 proteins in the licensing of DNA replication. Trends Biochem. Sci. 21, 102-106.
8. Cocker, J.H., Piatti, S., Santocanale, C., Nasmyth, K., and Diffley, J.F. (1996). An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379, 180-182.
9. Coleman, T.R., Carpenter, P.B., and Dunphy, W.G. (1996). The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87, 53-63.
10. Detweiler, C.S., and Li, J.J. (1997). Cdc6p establishes and maintains a state of replication competence during G1 phase. J. Cell Sci. 110, 753-763.
11. Diffley, J.F., Cocker, J.H., Dowell, S.J., and Rowley, A. (1994). Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78, 303-316.
12. Donovan, S., Harwood, J., Drury, L.S., and Diffley, J.F. (1997). Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc. Natl. Acad. Sci. USA 94, 5611-5616.
13. Elsasser, S., Lou, F., Wang, B., Campbell, J.L., and Jong, A. (1996). Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases. Mol. Biol. Cell 7, 1723-1735.
14. Feng, L., Wang, B., and Jong, A. (1998). Saccharomyces cerevisiae Cdc6 stimulates Abf1 DNA binding activity. J. Biol. Chem. 273, 1298-1302.
15. Feng, L., Hu, Y., Wang, B., and Jong, A.Y. Identification and characterization of the DNA binding properties of the Saccharomyces cerevisiae CDC6 gene product. Mol. Biol. Cell 11, 1673-1685.
16. Gavin, K.A., Hidaka, M., and Stillman, B. (1995). Conserved initiator proteins in eukaryotes. Science 270, 1667-1671.
17. Hartwell, L.H. (1976). Sequential function of gene products relative to DNA synthesis in the yeast cell cycle. J. Mol. Biol. 104, 803-817.
18. Hennessy, K.M., Lee, A., Chen, E., and Botstein, D. (1991). A group of interacting yeast DNA replication genes. Genes Dev. 5, 958-969.
19. Hogan, E., and Koshland, D. (1992). Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 89, 3098-3102.
20. Klemm, R.D., Austin, R.J., and Bell, S.P. (1997). Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex. Cell 88, 493-502.
21. Kornberg, A., and Baker, T.A. (1992). DNA Replication. (W.H. Freeman and Company, New York).
22. Leatherwood, J., Lopez-Girona, A., and Russell, P. (1996). Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein. Nature 379, 360-363.
23. Lei, M., Kawasaki, Y., and Tye, B.K. (1996). Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 5081-5090.
24. Li, J.J., and Herskowitz, I. (1993). Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system. Science 262, 1870-1874.
25. Liang, C., and Stillman, B. (1997). Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev. 11, 3375-3386.
26. Liang, C., Weinreich, M., and Stillman, B. (1995). ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell 81, 667-676.
27. Muzi-Falconi, M., and Kelly, T.J. (1995). Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex. Proc. Natl. Acad. Sci. USA 92, 12475-12479.
28. Nasmyth, K. (1996). Viewpoint: Putting the cell cycle in order. Science 274, 1643-1645.
29. Perkins, G., and Diffley, J.F. (1998). Nucleotide-dependent pre-replicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders. Mol. Cell 2, 23-32.
30. Piatti, S., Bohn, T., Cocker, J.H., Diffley, J.F., and Nasmyth, K. (1996). Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes Dev. 10, 1516-1531.
31. Piatti, S., Lengauer, C., and Nasmyth, K. (1995). Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J. 14, 3788-3799.
32. Rowles, A., Chong, J.P., Brown, L., Howell, M., Evan, G.I., and Blow, J.J. (1996). Interaction between the origin recognition complex and the replication licensing system in Xenopus. Cell 87, 287-296.
33. Saha, P., Chen, J., Thome, K.C., Lawlis, S.J., Hou, Z.H., Hendricks, M., Parvin, J.D., and Dutta, A. (1998). Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol. Cell. Biol. 18, 2758-2767.
34. Santocanale, C., and Diffley, J.F. (1996). ORC-and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae. EMBO J. 15, 6671-6679.
35. Stillman, B. (1996). Cell cycle control of DNA replication. Science 274, 1659-1664.
36. Strahl-Bolsinger, S., Hecht, A., Luo, K., and Grunstein, M. (1997). SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast. Genes Dev. 11, 83-93.
37. Tanaka, T., Knapp, D., and Nasmyth, K. (1997). Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell 90, 649-660.
38. Tye, B.K. (1994). The MCM2-3-5 proteins: Are they replication licensing factors? Trends Cell Biol. 4, 160-166.
39. Wang, B., Feng, L., Hu, Y., Huang, S.H., Reynolds, C.P., Wu, L., and Jong, A.Y. (1999). The essential role of Saccharomyces cerevisiae CDC6 nucleotide-binding site in cell growth, DNA synthesis, and Orc1 association. J. Biol. Chem. 274, 8291-8298.
40. Weinreich, M., Liang, C., and Stillman, B. (1999). The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatin. Proc. Natl. Acad. Sci. USA 96, 441-446.
41. Williams, R.S., Shohet, R.V., and Stillman, B. (1997). A human protein related to yeast Cdc6p. Proc. Natl. Acad. Sci. USA 94, 142-147.
42. Yan, H., Merchant, A.M., and Tye, B.K. (1993). Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast. Genes Dev. 7, 2149-2160.
43. Young, M.R., and Tye, B.K. (1997). Mcm2 and Mcm3 are constitutive nuclear proteins that exhibit distinct isoforms and bind chromatin during specific cell cycle stages of Saccharomyces cerevisiae. Mol. Biol. Cell 8, 1587-1601.
44. Zhou, C., Huang, S.H., and Jong, A.Y. (1989). Molecular cloning of Saccharomyces cerevisiae CDC6 gene: Isolation, identification, and sequence analysis. J. Biol. Chem. 264, 9022-9029.
45. Zhou, L., and Stillman, B. (1998). Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin. Science 280, 593-596.