Characterization of CPT-11 converting carboxylesterase activity in colon tumor and normal tissues: Comparison with p-nitro-phenylacetate converting carboxylesterase activity

Anti-Cancer Drugs

Volumn 11, Issue 6, 2000, Pages 465-470

  Hennebelle, Isabelle ^a   Terret, Catherine ^a   Chatelut, Etienne ^a,b   Bugat, Roland ^a,b   Canal, Pierre ^a   Guichard, Sylvie ^a  

^a INSTITUT CLAUDIUS REGAUD   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Carboxylesterase; Colon carcinoma; CPT 11; Irinotecan

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; CARBOXYLESTERASE; DRUG METABOLIZING ENZYME; IRINOTECAN;

ARTICLE; COLON TUMOR; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME MECHANISM; HUMAN; HUMAN TISSUE; LIVER; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CARBOXYLIC ESTER HYDROLASES; COLON; COLONIC NEOPLASMS; DNA TOPOISOMERASES, TYPE I; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; KINETICS; LIVER; NITROPHENOLS; RATS; SUBSTRATE SPECIFICITY;

EID: 0033850667     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200007000-00007     Document Type: Article

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