Nonpeptide endothelin receptor antagonists. VIII: Attenuation of acute hypoxia-induced pulmonary hypertension in the dog

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 2, 1997, Pages 695-701

  Willette, Robert N ^b   Ohlstein, Eliot H ^b   Mitchell, Marcus P ^b   Sauermelch, Charles F ^b   Beck, George R ^b   Luttmann, Mark A ^a   Hay, Douguxs W P ^a  

^a SmithKline Beecham Pharmaceutical ^*  (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 CARBOXYMETHOXY 4 METHOXYPHENYL) 1 (3,4 METHYLENEDIOXYPHENYL) 5 PROPOXY 2 INDANCARBOXYLIC ACID; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; PHENYLEPHRINE; SARAFOTOXIN S6C;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG ANTAGONISM; DRUG POTENCY; DRUG SELECTIVITY; HYPOXIA; INTRAVENOUS DRUG ADMINISTRATION; ISOLATED ARTERY; LUNG BLOOD FLOW; LUNG CIRCULATION; LUNG HEMODYNAMICS; LUNG VASCULAR RESISTANCE; MALE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION;

ANIMALS; ANOXIA; BLOOD PRESSURE; DOGS; ENDOTHELIN-1; HEART RATE; HYPERTENSION, PULMONARY; INDANS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PHENYLEPHRINE; PULMONARY ARTERY; RECEPTORS, ENDOTHELIN; VASOCONSTRICTOR AGENTS; VIPER VENOMS;

EID: 0030948181     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. ALLEN, S. W., CHATFIELD, B. A., KOPPENHAFER, S. A., SCHAFFER, M. S., WOLFE, R. R. AND ABMAR, S. H.: Circulating immunoreactive endothlin-1 in children with pulmonary hypertension. Am. Rev. Respir. Dis. 148: 519-522, 1993.
2. ARCHER, S. L., CHESLER, E., COHN, J. N. AND WEIR, E. K.: ZK 36-374, A stable analog of prostacyclin, prevents acute hypoxic pulmonary hypertension in the dog. J. Am. Coll. Cardiol. 8: 1189-1194, 1986.
3. ARUNLAKSHANA, O. AND SCHILD, H. O.: Some quantitative uses of drug antagonists. Br. J. Pharmacol. 14: 48-58, 1959.
4. BARMAN, S. A., ARDELL, J. L. AND TAYLOR, A. E.: Effect of endothelin on Canine airway blood flow. J. Cardiovasc. Pharmacol. 22: suppl. 8, S274-S277, 1993.
5. BARNARD, J. W., BARMAN, S. A., ADKINS, W. K., LONGENECKER, G. L. AND TAYLOR, A. E.: Sustained effects of endothelin-1 on rabbit, dog, and rat pulmonary circulations. Am. J. Physiol. 261: H479-H486, 1991.
6. BONVALLET, S. T., ZAMORA, M. R., HASUNUMA, K., SATO, K., HANASATO, N., ANDERSON, D., SATO, K., STELZNER, T. J.: BQ123, an ETA-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats. Am. J. Physiol. 266: H1327-H1331, 1994.
7. CLOZEL, M., BREU, V., BURRI, K., CASSAL, J. M., FISCHLI, W., GRAY, G. A., HIRTH, G., LOFFLER, B. M., MULLER, M., NEIDHART, W. AND RAMUZ, H.: Pathophysiological role of endothlin revealed by the first orally active endothelin receptor antagonist. Nature 363: 759-763, 1993.
8. CODY, R. J., HAAS, G. J., BINKLEY, P. F., CAPERS, Q. AND KELLEY, R.: Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure. Circulation 85: 504-509, 1992.
9. DEMIRYUREK, A. T., WADSWORTH, R. M., KANE, K. A. AND PEACOCK, A. J.: The role of endothelium in hypoxic constriction of human pulmonary artery rings. Am. Rev. Respir. Dis. 147: 283-290, 1993.
10. DOUGLAS, S. A., VICKERY-CLARK, L. M. AND OHLSTEIN, E. H.: Endothelin-1 does not mediate hypoxic vasoconstriction in canine blood vessels effect of BQ-123. Br. J. Pharmacol. 108: 418-421, 1993.
11. EDDAHIBI, S., RAFFESTIN, B., CLOZEL, M., LEVAME, M. AND ADNOT, S.: Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in the hypoxic rat. Am. J. Physiol. 268: H828-H835, 1995.
12. EHRENREICH, H., ANDERSON, R. W., FOX, C. H., RIECKMANN, P., HOFFMAN, G. S., TRAVIS, W. D., COLRGAN, J. E., KEHKL, J. H. AND FAUCI, A. S.: Endothelin, peptides with potent vasoactive properties, are produced by human macrophages. J. Exp. Med. 172: 1741-1748, 1990.
13. GIAID, A., POLAK, J. M., GAITONDE, V., HAMID, Q. A., MOSCOSO, G., S. LEGON, UWANOGHO, D., RONCALLI, M. SHINMI, O. AND SAWAMURA, T.: Distribution of endothelin-like immunere activity and mRNA in the developing and adult human lung. Am. J. Respir. Cell Mol. Biol. 4: 50-58, 1991.
14. GOERRE, S., WENK, M., BARTSCH, P., LUSCHER, T. F., NIROOMAND, F., HOHENKAUS, E. OELZ, O. AND REINHART, W. H.: Endothelin-1 in pulmonary hypertension associated with high-altitude exposure. Circulation 90: 359-364, 1995.
15. HAY, D. W. P., LUTHMANN, M. A., HUBBARD, W. C. AND UNDEM, B. J.: Endothelin receptor subtypes in human and guinea-pig pulmonary tissues. Br. J. Pharmacol. 110: 1175-1183, 1993.
16. HAY, D. W. P. AND GOLDIE, R. G.: Role of endothelin in pulmonary disease. In Endothelin: Role in Health and Disease, ed. by A. Gulati, Harwood Academic, Chur, Switzerland, 1995: 251-273.
17. HENRY, P. J., RIGBY, P. J., SELF, G. J., PREUSS, J. M. AND GOLDIE, R. G.: Relationship between endothelin-1 binding sites ans constrictor activities in human and animal airway smooth muscle. Br. J Pharmacol. 100: 786-792, 1990.
18. HORIO, T. M., KOHNO, M., YOKOKAWA, K., YASUNARI, K., FUJIWARA, H., KURIHARA, N. AND TAKEDA, T.: Effect of hypoxia on plasma immunoreactive endothelin-1 concentration in anesthetized rats. Metab. Clin. Exp. 40: 999-1001, 1991.
19. A receptor subtypes. Life Sci. 50: 247-255, 1991.
20. KOVITZ, K. L., ALESKOWITCH, T. D., SYLVESTER, J. T. AND FLAVAHAN, N. A.: Endothelium-derived contracting and relaxing factors contribute to hypoxic responses of pulmonary arteries. Am. J. Physiol. 265: H1139-H1148, 1993.
21. LIPPTON, H. L., HAUTH, T. A., SUMMER, W. R. AND HYMAN, A.: Endothelin produces pulmonary vasoconstriction and systemic vasodilation. J. Appl. Physiol. 66: 1008-1012, 1989.
22. LAZOR, R., FEIHL, F., WAEBER, B., KUCERA, P. AND PERRET, C.: Endothelin-1 does not mediate the endothelium-dependent hypoxic contractions of small pulmonary arteries in rats. Chest 110: 189-197, 1996.
23. LOFFLER, B-M., BREU, V. AND CLOZEL, M.: Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro. 46-2005 on endothelin levels in rat plasma. FEBS Lett. 333: 108-110, 1993.
24. MACCUMBER, M. W., Ross, C. A., GLASER, B. M. AND SNYDER, S. H.: Endothelin visualization of mRNA by in situ hybridization provides evidence for local action. Proc. Natl. Acad. Sci. U.S.A. 86: 7285-7289, 1989.
25. A- and ETB-receptor-mediated vasoconstriction in rat pulmonary artreies and arterioles. Cardiovasc. Pharmacol. 23: 838-845, 1994.
26. MIYAUCHI, T., YORIKANE, R., SAKAI, S., SAKURAI, T., OKADA, M., NISHIKIBE, M., YANO, M., YAMAGUCHI, I., SUGISHITA, Y. AND GOTO, K.: Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced oulmonary hypertension. Circ. Res. 73: 887-897, 1993.
27. OHLSTEIN, E. H., ARLETH, A., EZEKIEL, M., HOROHOUICH, S., ATOR, M. A., CALTABIANO, L. M. AND SUNG, C. P.: Biosynthesis and modulation of endothelin from bovine pulmonary arterial endothelial cells. Life Sci. 46: 181-188, 1990.
28. OHLSTEIN, E. H., NAMBI, P., DOUGLAS, S. A., EDWARDS, R. M., GELLAI, M., LAGO, A., LEBER, J. D., COUSINS, R., GAO, A., FRAZEE, J., PEISHOFF, C., BEAN, J. W., EGGLESTON, D. S., ELSHOURBAGY, N., KUMAR, C., LEE, J. A., BROOKS, D. P., WEINSTOCK, J., FEUERSTEIN, G., POSTE, G., RUFFOLO, R. R., GLEASON, J. G. AND ELLIOT, J. D.: A rationally designed potent nonpeptide endothelin receptor antagonist. Proc. Natl. Acad. Sci. U.S.A. 91: 8052-8056, 1994.
29. OHLSTEIN, E. H., NAMBI, P. AND RUFFOLO, R.: Endothelin receptor subclassification. In Endothelin Receptors from the Gene to the Human, ed. by R. R. Ruffolo, CRC Press, Inc., New York, 1995: 15-36.
30. OKADA, M., YAMASHITA, C., OKADA, M. AND OKADA, K.: Endothelin receptor antagonists in a beagle model of pulmonary hypertension: Contribution to possible potential therapy. J. Am. Coll. Cardiol. 25: 1213-1217, 1995.
31. OPARIL, S., CHEN, J-J., MENG, Q. C., ELTON, T. S., YANO, M. AND CHEN, Y-F.: Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat. Am. J. Physiol. 268: L95-L100, 1995.
32. PINHEIRO, J. M. B. AND MALIK, A. B.: Mechanisms of endothelin-1-induced pulmonary vasodilation in neonatal pigs. J. Physiol. 469: 739-752, 1993.
33. SHIRAKAMI, G., NAKAO, K., SAITO, Y., MAGARIBUCHI, T., JOUGASAKI, M., MUKOYAMA, M., ARM, K., HOSODA, K., SUGA, S., OGAWA, Y., YAMADA, T., MORI, K. AND IMURA, H.: Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats. Life Sci. 48: 969-976, 1995.
34. TEERLINK, J. R., CARTEAUX, J.-P., SPRECHER U., LOFFLER, B.-M., CLOZEL, M. AND CLOZEL, J.-P.: Role of endogenous endothelin in normal hemodynamic status of anesthetized dogs. Am. J. Physiol. 268: H432-H440, 1995.
35. TURNER, N. C., POWER, R. F., POLAK, J. M., BLOOM, S. R. AND DOLLERY, C. T.: Endothelin-induced contractions of tracheal smooth muscle and identification of specific endothelin binding sites in the trachea of the rat. Br. J. Pharmacol. 98: 361-366, 1989.
36. VAN ROSSUM, J. M.: Cumulative dose response curves II. Arch. Int. Pharmacodyn. Ther. 143: 299-330, 1963.
37. VOELKEL, N. F.: Mechanisms of hypoxic pulmonary vasoconstriction. Am. Rev. Respir. Dis. 133: 1186-1195, 1986.
38. WALLENSTEIN, S., ZUCKER, C. I. AND FLEISS, J. L.: Some statistical methods useful in circulation research. Circ. Res. 47: 1-9, 1980.
39. WANG, Y., COE, Y., TOYODA, O. AND COCEANI, F.: Involvement of endothelin-1 in hypoxic pulmonary vasoconstriction in the lamb. J. Physiol. 482: 421-434, 1995.
40. WARNER, T. D., ALLCOCK, G. H., MICKLEY, E. J., CORDEN, R. AND VANE, J. R.: Comparative studies with endothelin antagonists BQ-123 and PD142893 indicate at least three endothelin receptors. J. Cardiovasc. Pharmacol. 22: suppl. 8, 117-121, 1993.
41. WILLETTE, R. N., ZHANG, H., MITCHELL, M. P., SAUERMELCH, C. F., OHLSTEIN, E. H., SULPIZIO, A. C.: Nonpeptide endothelin antagonist: Cerebrovascular characterization and effects on delayed cerebral vasospasm. Stroke 25: 2450-2456, 1994.
42. WONG, J., VANDERFORD, P. A., WINTERS, J., SOIFER, S. J. AND FINEMAN, J. R.: Endothelin-B receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension. J. Cardiovasc. Pharmacol. 25: 207-215, 1995.
43. WONG, J., VANDERFORD, P. A., FINEMAN, J. R., CHANG, R. AND SOIFER, S. J.: Endothlein-1 produces pulmonary vasodilation in the intact newborn lamb. Am. J. Physiol. 265: H1318-H1325, 1993.
44. A receptor antagonist, inhibits endothlein-1-mediated proliferation of human pulmonary artery smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 9: 429-433, 1993.