Staphylococcal toxin-induced T cell proliferation in atopic eczema correlates with increased use of superantigen-reactive Vβ-chains in cutaneous lymphocyte-associated antigen (CLA)-positive lymphocytes

Clinical and Experimental Immunology

Volumn 121, Issue 2, 2000, Pages 181-186

  Davison, S ^a   Allen, M ^a   Vaughan, R ^a   Barker, J ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Eczema; Lymphocyte; Skin homing; Superantigen

Indexed keywords

CONCANAVALIN A; LYMPHOCYTE ANTIGEN; PHYTOHEMAGGLUTININ; STAPHYLOCOCCUS ENTEROTOXIN A; STAPHYLOCOCCUS ENTEROTOXIN B; STAPHYLOCOCCUS TOXIN; T LYMPHOCYTE RECEPTOR; TOXIC SHOCK SYNDROME TOXIN 1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ATOPIC DERMATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; LYMPHOCYTE PROLIFERATION; MALE; MONONUCLEAR CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; ANTIGENS, BACTERIAL; ANTIGENS, NEOPLASM; BACTERIAL TOXINS; CHEMOTAXIS, LEUKOCYTE; CONCANAVALIN A; DERMATITIS, ATOPIC; ENTEROTOXINS; FEMALE; FLOW CYTOMETRY; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; PHYTOHEMAGGLUTININS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SKIN; STAPHYLOCOCCAL SKIN INFECTIONS; SUPERANTIGENS; T-LYMPHOCYTE SUBSETS;

EID: 0033847660     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01270.x     Document Type: Article

References (18)

1. Microbial flora of atopic dermatitis
2. On the resident aerobic bacterial skin flora in unaffected skin of patients with atopic dermatitis and in healthy controls
3. Superantigenic exotoxin secreting potential of staphylococci isolated from atopic eczematous skin
4. Prevalence and role of serum IgE antibodies to the Staphylococcus aureus-derived superantigens SEA and SEB in children with atopic dermatitis
5. Staphylococcal enterotoxin B applied on intact normal and intact atopic skin induces dermatitis
6. Staphylococcal enterotoxin B (SEB) affects in vitro IgE synthesis, IFNγ, IL-4 and IL-5 production in atopic eczema
7. Presence of IgE antibodies to staphylococcal enterotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens
8. Atopic dermatitis and staphylococcal superantigens
9. Superantigens
10. Preferential expression T-cell receptor Vβ-chains in atopic eczema
11. Evidence for superantigen involvement in skin homing of T cells in atopic dermatitis
12. Circulating CLA+ lymphocytes from children with atopic dermatitis contain an increased percentage of cells bearing staphylococcal-related T-cell receptor variable segments
13. Non-specific T cell homing during inflammation in atopic dermatitis: Expression of cutaneous lymphocyte associated antigen and integrin α(E)β7 on skin-infiltrating T cells
14. Circulating allergen reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen
15. Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production
16. Diagnostic features of atopic dermatitis
17. Role of staphylococcal enterotoxins in pathogenesis of atopic dermatitis: Growth and expression of T cell receptor Vβ of peripheral blood mononuclear cells stimulated by enterotoxins A and B
18. Superantigens but not mitogens are capable of inducing upregulation of E-selectin ligands on human T lymphocytes