Prevalence and role of serum IgE antibodies to the Staphylococcus aureus-derived superantigens SEA and SEB in children with atopic dermatitis

Journal of Allergy and Clinical Immunology

Volumn 103, Issue 1 I, 1999, Pages 119-124

  Bunikowski, Rita ^a   Mielke, Martin ^b   Skarabis, Horst ^b   Herz, Udo ^a   Bergmann, Renate L ^a   Wahn, Ulrich ^a   Renz, Harald ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Atopic dermatitis; S aureus colonization density; Severity of AD risk factors for sensitization to SEB SEA; Specific IgE to SEA SEB; Staphylococcal enterotoxins; Superficial S aureus skin infection; Total serum IgE

Indexed keywords

IMMUNOGLOBULIN E; STAPHYLOCOCCUS ENTEROTOXIN A; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN;

ADOLESCENT; ANTIBODY SPECIFICITY; ARTICLE; ATOPIC DERMATITIS; BACTERIAL COLONIZATION; CHILD; DISEASE SEVERITY; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; INFANT; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

EID: 0032893309     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(99)70535-X     Document Type: Article

References (42)

1. Bergmann RL, Bergmann KE, Lau-Schadensdorf S, et al. Atopic disease in infancy: the German multicenter atopy study (MAS-90). Pediatr Allergy Immunol 1994;5(suppl):19-25.
2. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol 1980;92:44-7.
3. Sampson HA. Pathogenesis of eczema. Clin Exp Allergy 1990;20:459-67.
4. Bock SA, Lee WY, Remigio LK, May CD. Studies of hypersensitivity reactions to foods in infants and children. J Allergy Clin Immunol 1978;62:327-34.
5. Reitamo S, Visa K, Kahonen K, Kyhk K, Stubb S, Salo O. Eczematous reactions in atopic dermatitis patients caused by epicutaneous testing with inhalant allergens. Br J Dermatol 1986;140:303-9.
6. Valenta R, Maurer D, Steiner R, et al. Immunglobulin E response to human proteins in atopic patients. J Invest Dermatol 1996;107:203-8.
7. Bruijnzeel-Koomen CAFM, Wichen v DE, Spry CJF, Venge P, Bruijnzeel PLB. Active participation of eosinophils in patch test reactions to inhalant allergens in patients with atopic dermatitis. Br J Dermatol 1988;118:229-38.
8. Norris PG, Schofield O, Camp RDR. A study of the role of house dust mite in atopic dermatitis. Br J Dermatol 1988;118:435-40.
9. H2 phenotype in patients with atopic dermatitis. J Allergy Clin Immunol 1992;90:184-93.
10. Ramb-Lindauer CH, Feldmann A, Rotte M, Neumann C. Characterization of grass pollen reactive T-cell lines derived from lesional atopic skin. Arch Dermatol Res 1991;283:71-6.
11. Werfel T, Morita A, Grewe M, et al. Allergen specificity of skin-infiltrating T cells is not restricted to a Type-2 cytokine pattern in chronic skin lesions of atopic dermatitis. J Invest Dermatol 1996;107:871-6.
12. Sager N, Feldmann A, Schilling G, Kreitsch P, Neumann C. House dust mite-specific T-cells in the skin of subjects with atopic dermatitis frequency and lymphokine profile in the allergen patch test. J Allergy Clin Immunol 1992;89:801-10.
13. Hanifin JM, Rogge JL. Staphylococcal infections in patients with atopic dermatitis. Arch Dermatol 1977;113:1383-6.
14. David TJ, Cambridge GC. Bacterial infection and atopic eczema. Arch Dis Childhood 1986;61:20-3.
15. Leyden JE, Marpies RR, Kligman AM. Staphylococcus aureus in the lesions of atopic dermatitis. Br J Dermatol 1974;90:525-30.
16. Aly R, Maibach H, Shinefield H. Microbial flora of atopic dermatitis. Arch Dermatol 1977;113:780-2.
17. Michie CA, Davis T. Atopic dermatitis and Staphylococcal superantigens. Lancet 1996;347:324.
18. Akiyama H, Toi Y, Kanzaki H, Tada J, Arata J. Prevalence of producers of enterotoxins and toxic shock syndrome toxin-1 among Staphylococcus aureus strains isolated from atopic dermatitis lesions. Arch Dermatol Res 1996;288:418-20.
19. Hoeger PH, Lenz W, Boutonnier A, Fournier JM. Staphylococcal skin colonization in children with atopic dermatitis: prevalence, persistence, and transmission of toxigenic and nontoxigenic strains. J Infect Dis 1992;165:1064-8.
20. Strange P, Skov L, Lisby S, Nielsson LP, Balsgaard O. Staphylococcal enterotoxin B applied on intact normal and intact atopic skin induces dermatitis. Arch Dermatol 1996;132:27-33.
21. Leung DY, Harbeck R, Bina P, et al. Presence of IgE antibodies to Staphylococcal exotoxins on the skin of patients with atopic dermatitis: evidence for a new group of allergens. J Clin Invest 1993;92:1374-80.
22. Marrack P, Kappler J. The Staphylococcal enterotoxins and their relatives. Science 1990;248:705-11.
23. Mollick JA, McMasters RL, Grossmann D, Rich R. Localization of a site on bacterial superantigens that determines T cell receptor β chain specificity. J Exp Med 1993;177:283-93.
24. Kappler JW, Herman A, Clements J, Marrack P. Mutations defining functional regions of the superantigen Staphylococcal enterotoxin B. J Exp Med 1992;175:387-96.
25. Tada J, Toi Y, Akiyama H, Arata J. Presence of specific IgE antibodies to Staphylococcal enterotoxins in patients with atopic dermatitis. Eur J Dermatol 1996;6:552-4.
26. European Task Force on Atopic Dermatitis. Severity scoring of atopic dermatitis: the SCORAD index: consensus report of the task force on atopic dermatitis. Dermatology 1993;186:23-31.
27. Caskey L. Processing of skin on subcutaneous tissue specimen. In: Isenberg HD, editor. Clinical microbiology procedures handbook, vol 1. Washington (DC): American Society for Microbiology; 1992. p. 1.16.1-.15.
28. McSharry C, McKay IC, Lewis C. Methods for quantifying allergen-specific IgE antibodies: solid-phase and liquid-phase techniques. J Clin Immunoassay 1993;16:153-8.
29. Motala C, Potter PC, Weinberg EG, Malherbe D, Hughes J. Anti-staphylococcus aureus-specific IgE in atopic dermatitis. J Allergy Clin Immunol 1986;78:583-9.
30. Bieber T, Dannenberg B, Ring J, Braun-Falco O. Keratinocytes in lesional skin of atopic eczema bear HLA-DR CD la and IgE molecules. Clin Exp Dermatol 1989;14:35-9.
31. Strange P, Skov L, Baadsgaard O. Interferon-gamma-treated keratinocytes activate T cells in the presence of superantigens: involvement of major histocompatiblity complex class II molecules. J Invest Dermatol 1994;102:150-4.
32. Tokura Y, Yagi J, O'Malley M, et al. Superantigenic staphylococcal exotoxins induce T cell proliferation in the presence of Langerhans cells or class II-bearing keratinocytes and stimulate keratinocytes to produce T-cell activating cytokines. J Invest Dermatol 1994;102:131-8.
33. Lester MR, Hofer MF, Renz H, Trumble AE, Gelfand EW, Leung DYM. Modulatory effects of staphylococcal superantigen TSST-1 on IgE synthesis in atopic dermatitis. Clin Immunol Immunopathol 1995;77:332-8.
34. König B, Neuber K, König W. Responsiveness of peripheral blood mononuclear cells from normal and atopic donors to microbial superantigens. Int Arch Allergy Immunol 1995;106:124-33.
35. Neuber K, Steinrücke K, Ring J. Staphylococcal enterotoxin B affects in vivo IgE synthesis, interferon-7, interleukin-4 and interleukin-5 production in atopic eczema. Int Arch Allergy Immunol 1995;107:179-82.
36. Hofer MF, Lester MR, Schlievert PM, Leung DYM. Upregulation of IgE synthesis by staphylococcal toxic shock syndrome toxin-1 in peripheral blood mononuclear cells from patients with atopic dermatitis. Clin Exp Allergy 1995;25:1218-27.
37. Campbell DE, Kemp AS. Proliferation and production of interferon-gamma (IFN.G) and IL-4 in response to Staphylococcus aureus and staphylococcal superantigen in childhood atopic dermatitis. Clin Exp Immunol 1997;107:392-7.
38. Schopfer K, Baerlocher K, Price P, Krech U, Quie PG, Douglas SG. Staphylococcal IgE antibodies, hyperimmunoglobulinemia E and Staphylococcus aureus infections. N Engl J Med 1979;300:835-8.
39. Berger M, Kirkpatrick CH, Goldsmity PK, Gallin JI. IgE antibodies to Staphylococcus aureus and Candida albicans in patients with the syndrome of hyperimmunoglobulin E and recurrent infections. J Immunol 1980;125:2437-42.
40. Geha RS, Reinherz EL, Leung DYM, Schlossmann S, Rosen FS. Supressor T cell deficiency in the hyper IgE syndrome. J Clin Invest 1981;68:783-91.
41. Kristiansen SV, Pascual V, Lipsky PE. Staphylococcal protein A induces biased product of Ig by VH3-expressing B lymphocytes. J Immunol 1994;153:2974-82.
42. Domiati-Saad R, Attrep JF, Brezinschek HP, Cherrie AH, Karp DR, Lipsky PE. Staphylococcal enterotoxin D functions as a human B cell superantigen by rescuing VH4-Expressing B cells from apoptosis. J Immunol 1996;156:3608-20.