Vesicular transport of newly synthesized cytochromes P4501A to the outside of rat hepatocyte plasma membranes

Journal of Pharmacology and Experimental Therapeutics

Volumn 294, Issue 3, 2000, Pages 1063-1069

  Robin, M A ^a   Descatoire, V ^a   Le Roy, M ^a   Berson, A ^a   Lebreton, F P ^a   Maratrat, M ^a   Ballet, F ^a   Loeper, J ^a   Pessayre, D ^a  

^a BEAUJON HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; COLCHICINE; CYTOCHROME P450 1A; CYTOCHROME P450 ISOENZYME; CYTOCHROME P450 REDUCTASE; DIHYDRALAZINE; METHIONINE; SULFUR 35; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE HEPATITIS; BIOTINYLATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SYNTHESIS; FLOW CYTOMETRY; HALF LIFE TIME; IMMUNOPRECIPITATION; ISOTOPE LABELING; LIVER CELL CULTURE; LIVER CELL MEMBRANE; MEMBRANE STRUCTURE; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT; TOXIC HEPATITIS;

ANIMALS; ANTIBODY SPECIFICITY; BIOLOGICAL TRANSPORT; BIOTINYLATION; CELL MEMBRANE; CELLS, CULTURED; COATED VESICLES; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; FLOW CYTOMETRY; LIVER; MALE; MICROSCOPY, CONFOCAL; NADPH-FERRIHEMOPROTEIN REDUCTASE; PRECIPITIN TESTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033847371     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Detection of aromatase cytochrome P450, 17α-hydroxylase cytochrome P450 and NADPH:P450 reductase on the surface of cells in which they are expressed
2. Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug
3. Membrane topology of liver microsomal cytochrome P450 2B4 determined via monoclonal antibodies directed to the halt transfer signal
4. Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis
5. Anti-liver microsomes autoantibodies and dihydralazine-induced hepatitis: Specificity of autoantibodies and inductive capacity of the drug
6. Anti-liver endoplasmic reticulum autoantibodies are directed against human liver cytochrome P-450 IA2. A specific marker of dihydralazine-induced hepatitis
7. Interactions of dihydralazine with cytochromes P4501A: A possible explanation for the appearance of anti-P4501A2 autoantibodies
8. Determination of the membrane topology of the phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4 using site-specific antibodies
9. Cytochrome P4502E1 is a cell surface autoantigen in halothane hepatitis
10. Natural products which interact with tubulin in the vinca domain: Maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B
11. Interactions of colchicine with tubulin
12. Effect of caffeine and reduced temperature (20°C) on the organization of the pre-Golgi and the Golgi stack membranes
13. Membrane topology of NADPH-cytochrome P450 reductase on the endoplasmic reticulum
14. Cytochromes P-450 on human hepatocyte plasma membrane. Recognition by several autoantibodies
15. Presence of functional cytochrome P-450 on isolated rat hepatocyte plasma membrane
16. Topology inversion of CYP2D6 in the endoplasmic reticulum is not required for plasma membrane transport
17. Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1
18. Post-Golgi membrane traffic: Brefeldin A inhibits export from distal Golgi compartments to the cell surface but not recycling
19. On the membrane topology of vertebrate cytochrome P-450 proteins
20. Enzyme-specific transport of rat liver cytochrome P450 to the Golgi apparatus
21. Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis
22. Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera
23. Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes
24. Glycosylation: Heterogeneity and the 3D structure of proteins
25. A short amino-terminal segment of microsomal cytochrome P-450 functions both as an insertion signal and a stop-transfer sequence
26. An immunochemical approach to investigating the mechanism of halothane-induced hepatotoxicity
27. 2-terminal substitutions of basic amino acids induce translocation across the microsomal membrane and glycosylation of rabbit cytochrome P450IIC2
28. Decrease in hepatic cytochrome P-450 by cobalt. Evidence for a role of cobalt protoporphyrin
29. The interleukin-2 receptor down-regulates the expression of cytochrome P450 in cultured rat hepatocytes
30. Localization of the N-terminal methionine of rat liver cytochrome P-450 in the lumen of the endoplasmic reticulum
31. Selective reentry of recycling cell surface glycoprotein to the biosynthetic pathway in human hepatocarcinoma HepG2 cells