Topology inversion of CYP2D6 in the endoplasmic reticulum is not required for plasma membrane transport

Molecular Pharmacology

Volumn 53, Issue 3, 1998, Pages 408-414

  Loeper, Jacqueline ^a,b   Le Berre, Annie ^a   Pompon, Denis ^a  

^a CENTRE DE GÉNÉTIQUE MOLÉCULAIRE   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL MEMBRANE TRANSPORT; DEMETHYLATION; DNA POLYMORPHISM; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; GENE SEQUENCE; LIVER CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION;

EID: 0031968074     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.53.3.408     Document Type: Article

References (27)

1. Alves C, von Dippe P, Amoui M, and Levy D (1993) Bile acid transport into hepatocyte smooth endoplasmic reticulum vesicles is mediated by microsomal epoxide hydrolase, a membrane protein exhibiting two distinct topological orientations. J Biol Chem 268:20148-20155.
2. Brewer C and Roth MG (1991) A single amino acid change in the cytoplasmic domain alters the polarized delivery of influenza virus hemagglutinin. J Cell Biol 114: 413-421.
3. Cooper MB, Craft JA, Estall MR, and Rabin BR (1980) Asymmetric distribution of cytochrome P-450 and NADPH-cytochrome P-450 (cytochrome c) reductase in vesicles from smooth endoplasmic reticulum of rat liver. Biochem J 190:737-746.
4. Eliasson E and Kenna JG (1996) Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. Mol Pharmacol 50:573-582.
5. Gautier JC, Lecoeur S, Cosme J, Perret A, Urban P, Beaune PH, and Pompon D (1996) Contribution of human cytochrome P450 to benzo(a)pyrene and benzo(a)pyrene-7,8-dihydrodiol metabolism, as predicted from heterologous expression in yeast. Pharmacogenetics 6:489-499.
6. Guengerich FP, Bryan WR, Sari MA, and Ross JT (1991) Expression of mammalian cytochrome P450 enzymes using yeast-based vectors. Methods Enzymol 206:130-145.
7. Harsay E and Bretscher A (1995) Parallel secretory pathways to the cell surface in yeast. J Cell Biol 131:297-310.
8. Kiffel L, Loeper J, Homberg JC, and Leroux JP (1989) A human cytochrome P-450 is recognized by anti-liver/kidney microsome antibodies in autoimmune hepatitis. Biochem Biophys Res Commun 159:283-288.
9. Lecoeur S, Andre C, and Beaune PH (1996) Tienilic acid-induced autoimmune hepatitis: Anti-liver and -kidney microsomal antibodies type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9. Mol Pharmacol 50:326-333.
10. Liu N and Brown DT (1993) Transient translocation of the cytoplasmic (endo) domain of a type I membrane glycoprotein into cellular membranes. J Cell Biol 120:877-883.
11. Loeper J, Descatoire V, Maurice M, Beaune P, Feldmann G, Larrey D, and Pessayre D (1990) Presence of functional cytoehrome P-450 on isolated rat hepatocyte plasma membrane. Hepatology 11:850-858.
12. Loeper J, Descatoire V, Maurice M, Beaune P, Belghiti J, Houssin D, Ballet F, Feldmann G, Guengerich FP, and Pessayre D (1993) Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies. Gastroenterology 104:203-216.
13. Manns MP, Johnson EF, Griffin KJ, Tan EM, and Sullivan KF (1989) The major target antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is P450 db1. J Clin Invest 83:1066-1072.
14. Manns MP, Griffin KJ, Sullivan KF, and Johnson EF (1991) LKM1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P450 monooxygenase. J Clin Invest 88:1370-1378.
15. Narula N, Mc Morrow I, Plopper G, Doherty J, Matlin KS, Burke B, and Stow JL (1992) Identification of a 200-kD, brefeldin-sensitive protein on golgi membranes. J Cell Biol 117:27-38.
16. Neve EP, Eliasson E, Pronzato MA, Albano E, Marinari U, and Ingelman-Sundberg M (1996) Enzyme-specific transport of rat liver cytochrome P450 to the Golgi apparatus. Arch Biochem Biophys 333:459-465.
17. Parez N, Herzog D, Jacqz-Aigrain E, Homberg JC, and Alvarez F (1996) Study of the B cell response to cytochrome P450IID6 in sera from chronic hepatitis C patients. Clin Exp Immunol 106:336-343.
18. Pompon D, Louerat B, Bronine A, and Urban P (1996) Yeast expression of animals and plant P450s in optimized redox environments. Methods Enzymol 272:51-64.
19. Robin MA, Maratrat M, Loeper J, Durand-Schneider AM, Tinel M, Ballet F, Beaune P, Feldmann G, and Pessayre D (1995) Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes. Gastroenterology 108:1110-1123.
20. Sato T, Sakaguchi M, Mihara K, and Omura T (1990) The amino-terminal structures that determine topological orientation of cytochrome P-450 in microsomal membrane. EMBO J 9:2391-2397.
21. Saucan L and Palade GE (1994) Membrane and secretory proteins are transported from the Golgi complex to the sinusoidal plasmalemma of hepatocytes by distinct vesicular carriers. J Cell Biol 125:733-741.
22. Schmidt R, Ackermann R, Kratky Z, Wasserman B, and Jacobson B (1983) Fast and efficient purification of yeast plasma membranes using cationic silica microbeads. Biochim Biophy Acta 732:421-427.
23. Schwientek, T, Lorenz C, and Ernst JF (1995) Golgi localization in yeast is mediated by the membrane anchor region of rat liver sialyltransferase. J Biol Chem 270: 5483-5489.
24. Stirling C, Rothblatt JJ, Hosobuchi M, Deshaies R, and Schekman R (1992) Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum. Mol Biol Cell 3:129-142.
25. Szczesna-Skorupa E and Kemper B (1993) An N-terminal glycosylation signal on cytochrome P450 is restricted to the endoplasmic reticulum in a luminal orientation. J Biol Chem 268:1757-1762.
26. Yamamoto AM, Cresteil D, Boniface O, Clerc F, and Alvarez F (1993) Characterization of anti-liver-kidney microsome antibody (anti-LKM1). Eur J Immunol 23: 1105-1111.
27. Zanger UM, Hauri HP, Loeper J, Homberg JC, and Meyer UA (1988) Antibodies against human cytochrome P-450 db1 in autoimmune hepatitis type II. Proc Natl Acad Sci USA 85:8256-8260.