Inorganic phosphate induces apoptosis of osteoblast-like cells in culture

Bone

Volumn 27, Issue 3, 2000, Pages 359-366

  Meleti, Z ^a   Shapiro, I M ^a   Adams, C S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apoptosis; Cell death; Human; Osteoblast; Phosphate

Indexed keywords

COLLAGEN TYPE 1; FOSCARNET; OSTEOCALCIN; OSTEOPONTIN; PHOSPHATE;

APOPTOSIS; ARTICLE; CELL ACTIVITY; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN TISSUE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; OSTEOBLAST; PHOSPHATE TRANSPORT; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION;

APOPTOSIS; BASE SEQUENCE; BONE RESORPTION; CELLS, CULTURED; COLLAGEN; DNA PRIMERS; FLUORESCENT DYES; HUMANS; MEMBRANE POTENTIALS; MICROSCOPY, ELECTRON; MITOCHONDRIA; OSTEOBLASTS; OSTEOCALCIN; OSTEOPONTIN; PHENOTYPE; PHOSPHATES; RHODAMINE 123; RNA, MESSENGER; SIALOGLYCOPROTEINS;

EID: 0033847088     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(00)00346-X     Document Type: Article

References (16)

1. Bradbeer J.N., Lindsay P.C., Reeve J. Fluctuation of mineral apposition rate at individual bone-remodeling sites in human iliac cancellous bone Independent correlations with osteoid width and osteoblastic alkaline phosphatase activity . J Bone Miner Res. 9:1994;1679-1686.
2. Hill P.A., Tumber A., Meikle M.C. Multiple extracellular signals promote osteoblast survival and apoptosis. Endocrinology. 138:1997;3849-3858.
3. Ihbe A., Baumann G., Heinzmann U., Atkinson M.J. Loss of the differentiated phenotype precedes apoptosis of ROS 17/2.8 osteoblast-like cells. Calcif Tissue Int. 63:1998;208-213.
4. Irie K., Ozawa H. Relationships between tooth eruption, occlusion and alveolar bone resorption Cytological and cytochemical studies of bone resorption on rat incisor alveolar bone facing the enamel . Arch Histochem Cytochem. 53:1990;497-509.
5. Hughes D.E., Dai A., Tiffee J.C., Li H.H., Mundy G.R., Boyce B.F. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta. Nature Med. 2:1996;1132-1136.
6. Jilka R.L., Weinstein R.S., Bellido T., Parfitt A.M., Manolagas S.C. Osteoblast programmed cell death (apoptosis) Modulation by growth factors and cytokines . J Bone Miner Res. 13:1998;793-802.
7. Kitajima I., Nakajima T., Imamura T., Takasaki I., Kawahara K., Okano T., Tokioka T., Soejima Y., Abeyama K., Maruyama I. Induction of apoptosis in murine clonal osteoblasts expressed by human T-cell leukemia virus type I tax by NF-κB and TNF-α J Bone Miner Res. 11:1996;200-210.
8. Mansfield K., Rajpurohit R., Shapiro I.M. Extracellular phosphate ions cause apoptosis of terminally differentiated epiphyseal chondrocytes. J Cell Physiol. 179:1999;276-286.
9. McGahon A.J., Martin S.J., Bissonnette R.P., Mahboubi A., Shi Y., Mogil R.J., Nishioka W.K., Green D.R. The end of the (cell) line Methods for the study of apoptosis in vitro . Meth Cell Biol. 46:1995;153-185.
10. Noble B.S., Stevens H., Loveridge N., Reeve J. Identification of apoptotic changes in osteocytes in normal and pathological human bone. Bone. 20:1997;273-282.
11. Owen T.A., Aronow M., Shalhoub V., Barone L.M., Wilming L., Tassinari M.S., Kennedy M.B., Pockwinse S., Lian J.B., Stein G.S. Progressive development of the rat osteoblast phenotype in vitro Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix . J Cell Physiol. 143:1990;420-430.
12. Rajpurohit R., Mansfield K., Ohyama K., Ewert D., Shapiro I.M. Chondrocyte death is linked to development of a mitochondrial membrane permeability transition in the growth plate. J Cell Physiol. 179:1999;287-296.
13. Scaduto R.C., Grotyohann L.W. Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Biophys J. 76:1999;469-477.
14. Shapiro I.M., Mansfield K., Teixeira C.M., Adams C., Horiguchi H., Rajpurohit R. Mechanism of induction of apoptosis in epiphyseal chondrocytes Role of phosphate ions and NO . J Bone Miner Res. 14:(Suppl. 1):1999;S434.
15. Silver I.A., Murrills R.J., Etherington D.J. Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp Cell Res. 175:1988;266-276.
16. Stein G.S., Lian J.B., Owen T.A. Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB J. 4:1990;3111-3123.