Human bone cell hyperpolarization response to cyclical mechanical strain is mediated by an interleukin-1β autocrine/paracrine loop

Journal of Bone and Mineral Research

Volumn 15, Issue 9, 2000, Pages 1746-1755

  Salter, D M ^a   Wallace, W H B ^b   Robb, J E ^b   Caldwell, H ^a   Wright, M O ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

Author keywords

Bone; Integrins; Interleukin 1 ; Mechanotransduction; Prostaglandin

Indexed keywords

APAMIN; CAFFEIC ACID; CALPHOSTIN C; GADOLINIUM; INDOMETACIN; INOSITOL TRISPHOSPHATE; INTERLEUKIN 1BETA; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; NEOMYCIN; PHOSPHOLIPASE C; PROSTAGLANDIN E2; PROTEIN KINASE C; VERAPAMIL;

ARTICLE; BONE REMODELING; BONE STRESS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IMMUNOREGULATION; MECHANICAL STRESS; MEMBRANE POTENTIAL; STRAIN DIFFERENCE;

ANTIBODIES; ANTIGENS, CD29; ARACHIDONIC ACID; AUTOCRINE COMMUNICATION; BONE AND BONES; CELLS, CULTURED; CHILD; CULTURE MEDIA, CONDITIONED; CYTOSKELETON; DINOPROSTONE; ELECTRIC STIMULATION; GADOLINIUM; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; ION CHANNELS; MEMBRANE POTENTIALS; PARACRINE COMMUNICATION; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033840502     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2000.15.9.1746     Document Type: Article

References (63)

1. Mechanical transduction in biological systems
2. Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain
3. Flow-related responses of intracellular inositol phosphate levels in cultured aortic endothelial cells
4. Mechanical stretch activates the stress activated protein kinases in cardiac myocytes
5. Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF
6. Flow-mediated endothelial mechanotransduction
7. In vitro studies of the effect of intermittent compressive forces on cartilage cell proliferation
8. Human osteoblast-like bone cells respond to mechanical strain with increased bone matrix protein production independent of hormonal regulation
9. Role of integrins in cellular responses to mechanical stress and adhesion
10. Mechanotransduction across the cell surface and through the cytoskeleton
11. Integrins: Versatility, modulation and signaling in cell adhesion
12. Integrin signalling transduces shear stress-dependent vasodilation of coronary arteries
13. Integrins and modulation of transmitter release from motor nerve terminals by stretch
14. Extracellular signal-regulated kinase and c-jun NH2 terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts
15. Hyperpolarisation of cultured human chondrocytes following cyclical pressurisation involves α5β1 integrin and integrin-associated intracellular pathways
16. Electrophysiological responses of human bone cells to mechanical stimulation: Evidence for specific integrin function in mechanotransduction
17. Response of plasma membrane to applied hydrostatic pressure in chondrocytes and fibroblasts
18. The effects of intermittent pressurisation on the electrophysiology of cultured human chondrocytes: Evidence for the presence of stretch activated membrane ion channels
19. Intracellular signal transduction pathways in human chondrocytes stimulated by intermittent pressurisation
20. Bone remodelling induced by physical stress is prostaglandin E2 mediated
21. Response of normal and osteoporotic human bone cells to mechanical stress in vitro
22. Mechanical strain-induced NO production by bone cells: A possible role in adaptive bone (re)modeling?
23. Nitric oxide response to shear stress by human bone cell cultures is endothelial nitric oxide synthase dependent
24. Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling
25. N-(6aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation
26. Calphostin C (UCN 1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
27. Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase
28. 2
29. 2+ release from isolated platelet membrane vesicles
30. Genistein, a specific inhibitor of tyrosine-specific protein kinases
31. Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle
32. Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions
33. Integrin functions and signal transduction
34. Pulsating fluid flow increases prostaglandin production by cultured chicken osteocytes - A cytoskeleton-dependent process
35. Signal transduction pathways involved in fluid flow-induced PGE2 production by cultured osteocytes
36. Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain
37. Fluid shear stress increases transforming growth factor beta 1 expression in human osteoblast-like cells: Modulation by cation channel blockades
38. Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells
39. Characterization of the signal transduction of prostaglandin E receptor EP1 subtype in cDNA-transfected Chinese hamster ovary cells
40. PGE2 increases substance P release from renal pelvic sensory nerves via activation of N-type calcium channels
41. Evaluation of signal transduction mechanisms for the mitogenic effects of prostaglandin E2 in normal human bone cells in vitro
42. Phorbol ester-induced production of prostaglandin E2 from phosphatidylcholine through the activation of phospholipase D in UMR-106 cells
43. Protein kinase C stimulates the small-conductance K+ channel in the basolateral membrane of the CCD
44. Osteoblast cytoskeletal modulation in response to mechanical strain in vitro
45. Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions
46. Stimulation of beta 1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors
47. Definition of two angiogenic pathways by distinct alpha v integrins
48. Beta 1 integrin-mediated interaction with extracellular matrix proteins regulates cytokine gene expression in synovial fluid cells of rheumatoid arthritis patients
49. Fibronectin receptor integrins are involved in mast cell activation
50. Regulation of interleukin 1 signalling through integrin binding and actin reorganization: Disparate effects on NF-kappaB and stress kinase pathways
51. Integrin-regulated secretion of interleukin 4: A novel pathway of mechanotransduction in human articular chondrocytes
52. Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes
53. Mechanotransduction in stretched osteocytes-temporal expression of immediate early and other genes
54. Signal transduction of mechanical stimuli is dependent on microfilament integrity: Identification of osteopontin as a mechanically induced gene in osteoblasts
55. The effects of recombinant human interleukin-1 beta on cellular proliferation and the production of prostaglandin E2, plasminogen activator, osteocalcin and alkaline phosphatase by osteoblast-like cells derived from human bone
56. Antioxidants inhibit interleukin-1-induced cyclooxygenase and nitric-oxide synthase expression in rat mesangial cells. Evidence for post-transcriptional regulation
57. Interleukin I regulates the expression of osteopontin mRNA by osteoblasts
58. Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes
59. Nitric oxide and bone
60. K+ channels and the intracellular calcium signal in human melanoma cell proliferation
61. Intracellular calcium, currents, and stimulus-response coupling in endothelial cells
62. Association of BCL-2 with membrane hyperpolarization and radioresistance
63. Protection from cell death by mcl-1 is mediated by membrane hyperpolarization induced by K(+) channel activation