Loss of E-cadherin expression associated with lymph node metastases in small breast carcinomas

Virchows Archiv

Volumn 430, Issue 4, 1997, Pages 285-289

  Hunt, N C A ^a   Douglas Jones, A G ^a   Jasani, B ^a   Morgan, J M ^a   Pignatelli, M ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Adhesion molecules; Breast neoplasia; Duct carcinoma of breast; E cadherin; Metastasis

Indexed keywords

UVOMORULIN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BREAST CARCINOMA; CANCER GRADING; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; LYMPH NODE METASTASIS; PRIORITY JOURNAL;

EID: 0031001004     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01092751     Document Type: Article

References (25)

1. Behrens J, Mareel MM, Van Roy FM, Birchmeier W (1989) Dissecting tumor cell invasion: epithelia acquire invasive properties alter the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 108:2435-2447
2. Bringuier PP, Umbas R, Schaafsma HE Karthaus HFM, Debruyne FMJ, Schalken JA (1993) Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumour's. Cancer Res 53:3241-3245
3. Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. 1. The value of histological grade in breast cancer: experience from a large study with long term follow up. Histopathology 19:403-410
4. Gabbert H E, Mueller W, Schneiders A, Meier S, Moll R, Birchmeier W, Hommel G (1996) Prognostic value of E-cadherin expression in 413 gastric carcinomas. Int J Cancer 69: 184-189
5. Gamallo C, Palacios J, Suarez A, Pizarro A, Navarro P, Quintanilla M, Cano A (1993) Correlation of E-cadherin expression with differentiation grade and histolosical type in breast carcinoma. Am J Pathol 142:987-993
6. Gibbs NM (1985) Comparative study of the histopathology of breast cancer in screened and unscreened population investigated by mammography. Histopathology 9:1307-1318
7. Jiang WG (1996) E-cadherin and its associated protein catenins, cancer invasion and metastases. Br J Surg 83:437-446
8. Lipponen P, Saarelainen E, Ji H, Aaltomaa S, Syrjanen K (1994) Expression of E-cadherin (E-CD) as related to other prognostic factors and survival in breast cancer. J Pathol (Lond) 174:101-109
9. Liu D, Nigam A K, Lalani E-N, Stamp GWH, Pignatelli M (1993) Transfection of E-cadherin into a human colon carcinoma cell line induces differentiation and inhibits growth in vitro. Gut 34:627
10. McCarty KS, Miller ES, Cox EB, Konrath J, McCarty KS (1985) Oestrogen receptor analysis: correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Arch Pathol Lab Med 109:716-721
11. Moll R, Mitze M, Frixen UH, Birchmeier W (1993) Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Am J Pathol 143:1731-1742
12. Nagafuchi A, Shirayoshi Y, Okazaki K, Yasuda K, Takeichi M (1987) Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature 329:341-343
13. Oka H, Shiozaki H, Kobayashi K, Inoue M, Tahara H, Kobayashi T, Takatsuka Y, Matsuyoshi N, Hirano S, Takeichi M, Mort T (1993) Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastases. Cancer Res 53:1696-1701
14. Page DL (1991) Prognosis and breast cancer. Recognition of lethal and favorable prognostic types. Am J Surg Pathol 15: 334-349
15. Palacios J, Benito N, Pizarro A, Soarez A, Espada J, Cano A, Gomallo C (1995) Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features. Am J Pathol 146:605-612
16. Pignatelli M, Vessey CJ (1994) Adhesion molecules: novel molecular tools in tumor pathology. Hum Pathol 25:849-856
17. Pizaro A, Benito N, Navarro P, Palacios J, Cano A, Quintanilla M, Contreras F, Gamallo C (1994) E-cadherin expression in basal cell carcinoma. Br J Cancer 69:157-162
18. Sakuragi N, Nishiya M, Ikeda K, Ohkouch T, Furth EE, Hareyama H, Satoh C, Fujimoto S (1994) Decreased E-cadherin expression in endometrial carcinoma is associated with tumour dedifferentiation and deep myometrial invasion. Gynecol Oncol 53:183-189
19. Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Shimosato Y, Takeichi M, Abe O (1989) Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res 49:2128-2133
20. Shiozaki H, Tahara H, Oka H, Miyata M, Kobayashi K, Tamura S, Iihara K, Doki Y, Hirano S, Takeichi M, Mori T (1991) Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol 139:17-23
21. Siitonen SM, Kononen JT, Helin HJ, Rantala IS, Holli KA, Isola JJ (1996) Reduced E-cadherin expression is associated with invasiveness and unfavourable prognosis in breast cancer. Am J Clin Pathol 105:394-402
22. Takayama T, Shiozaki H, Inoue M, Oka H, Tamura S, Takatsuka Y, Mori T (1994) Expression of E-cadherin and alpha catenin molecules in human breast cancer tissues and association with clinicopathological features. Int J Oncol 5:775-780
23. Umbas R, Isaacs WB, Bringuier PP, Schaafsma HE, Karthaus HFM (1994) Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res 54:3929-3933
24. Vandewalle B, Revillion F, Doutrelant P, Granier AM, Lefebvre J (1994) Effects of calcium on E-cadherin expression in breast tumour cells. Int J Oncol 4:181-185
25. Vessey C J, Wilding J, Polarin N, Hirano S, Takeichi M, Soutter P. Stamp GWH, Pignatelli M (1995) Altered expression and function of E-Cadherin in cervical intraepithelial neoplasia and invasive squamous carcinoma. J Pathol (Lond) 176: 151-159