Optimal oxygen tension conditions for viability and functioning of precision-cut liver slices

Experimental and Toxicologic Pathology

Volumn 52, Issue 4, 2000, Pages 335-338

  Drobner, C ^a   Glockner, R ^a   Muller, D ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

7 Ethoxycoumarin O deethylation; Culture media; Cytochrome P450; Liver slices precision cut; Oxygen tension

Indexed keywords

7 ETHOXYCOUMARIN DEETHYLASE; ALBUMIN; CYTOCHROME P450; DNA; OXYGEN; POTASSIUM; PROTEIN;

ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL VIABILITY; LIVER FUNCTION; LIVER METABOLISM; LIVER SLICE; MALE; NONHUMAN; OXYGEN TENSION; RAT; TEMPERATURE; TISSUE CULTURE;

ANIMALIA;

EID: 0033837235     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0940-2993(00)80059-7     Document Type: Article

References (22)

1. Acute suppression of albumin synthesis in systemic inflammatory disease: An individually graded response of rat hepatocytes
2. 2 transport resistances on the viability and functions of isolated rat hepatocytes
3. Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction
4. Determination of optimal incubation media and suitable slice diameters in precision-cut liver slices: Optimization of tissue slice culture, Part 2
5. Dynamic organ culture is superior to multiwell plate culture for maintaining precision-cut tissue slices: Optimization of tissue slice culture, Part 1
6. Use of fresh and cryopreserved human liver slices in toxicology with special reference to in vitro induction of cytochrome P450
7. Synthesis of secretory protein in regenerating liver of rat after partial hepatectomy
8. Reversible inhibition of albumin production by rat hepatocytes maintained on a laminin-rich gel (Engel-breth-Holm-Swarm) in response to secretory products of Kupffer Cells and Cytokines
9. Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices
10. 1 in rat liver slices using netwell inserts as a new culture system
11. Kupffer cells depress hepatocyte protein synthesis on cold storage of the rat liver
12. 2 tensions in serum-free primary culture
13. Monooxygenation, cytochrome P450-mRNA expression and other functions in precision-cut rat liver slices
14. Optimal oxygen tension conditions for functioning cultured hepatocytes in vitro
15. Liver slices in in vitro pharmacology with special reference to the use of human liver tissue
16. Use of precisioncut liver slices for studies of xenobiotic metabolism and toxicity: Comparison of the Krumdieck and Brendel tissue slicers
17. Oxygen tension, insulin, and glucagon affect the preservation and induction of cytochrome P450 isoforms in cultured rat hepatocytes
18. Variations of hepatic antioxydant systems and DNA ploidy in rats aged 2 to 8 months
19. Maintainance of adult rat liver slices in dynamic organ culture
20. Morphological and functional integrity of precision-cut rat liver slices in rotating organ culture and multiwell plate culture: Effect of oxygen tension
21. Kinetics of drug metabolism in rat liver slices III. Relationship between metabolic clearance and slice uptake rate
22. Resistance of precision-cut liver slices to the toxic effects of menandione