The carboxy terminus of the herpesvirus saimiri ORF 57 gene contains domains that are required for transactivation and transrepression

Journal of General Virology

Volumn 81, Issue 9, 2000, Pages 2253-2265

  Goodwin, D J ^a   Hall, K T ^a   Giles, M S ^a   Calderwood, M A ^a   Markham, A F ^a   Whitehouse, A ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; GENE PRODUCT; VIRUS PROTEIN; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE REPRESSION; HERPES SIMPLEX VIRUS; HERPES VIRUS SAIMIRI; HUMAN; HUMAN CELL; HYDROPHOBICITY; KIDNEY CELL; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; TRANSACTIVATION; VIRUS GENE;

ANIMALIA; DNA VIRUSES; HERPES; HERPESVIRIDAE; HUMAN HERPESVIRUS 4; SAIMIRI; SAIMIRIINE HERPESVIRUS 2; SIMPLEXVIRUS;

EID: 0033832979     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-81-9-2253     Document Type: Article

References (45)

1. Primary structure of the herpesvirus saimiri genome
2. The human herpesvirus-8 ORF 57 gene and its properties
3. Association of the cellular export receptor CRM 1 mediates function and intracellular localization of the Epstein-Barr virus SM protein, a regulator of gene expression
4. Herpes simplex virus trans-regulatory protein ICP27 stabilizes and binds to 3' ends of labile mRNA
5. The gene product encoded by ORF 57 of herpesvirus saimiri regulates the redistribution of the splicing factor, SC-35
6. Herpesvirus saimiri and herpesvirus ateles
7. The ORF 57 protein of herpesvirus saimiri shuttles between the nucleus and cytoplasm and is involved in viral RNA nuclear export
8. Recombinant genomes which express chloramphenicol acetyl-transferase in mammalian cells
9. The activation domain of the herpesvirus saimiri R protein interacts with the TATA-binding protein
10. The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection
11. The regions important for the activator and repressor functions of the herpes simplex virus alpha protein ICP27 map to the C-terminal half of the protein
12. Herpes simplex virus inhibits host cell splicing, and the regulatory protein ICP27 is required for this effect
13. Arginine-rich regions succeeding the nuclear localization region of herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expression
14. The Epstein-Barr virus BMLF1 promoter contains an enhancer element that is responsive to the BZLF1 and BRLF1 transactivators
15. Reactivation of Kaposi's Sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transativator, a homolog of the EBV R protein
16. The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to the C terminal regions and are required to modulate viral gene expression very early in infection
17. The RGG box of the herpes simplex virus ICP27 protein mediates RNA binding activity and determines in vivo methylation
18. Identification of nuclear and nucleolar localization signal sequences in the herpes simplex virus regulatory protein ICP27
19. Cell-homologous genes in Kaposi's sarcoma associated rhadinovirus human herpesvirus 8: Determinants of its pathogenicity?
20. Conservation of sequence and function between the product of the 52-kilodalton immediate-early gene of the herpesvirus saimiri and the BMLF1-encoded transcriptional effector (EB2) of the Epstein-Barr virus
21. Regulation of the herpesvirus saimiri (HVS) delayed-early 110-kilodalton promoter by HVS immediate-early gene products and a homolog of the Epstein-Barr virus R transactivator
22. Varicella-zoster virus open reading frame 4 encodes a transcriptional activator that is functionally distinct from that of herpes simplex virus homolog ICP27
23. Posttranscriptional regulation in herpes simplex virus
24. The Epstein-Barr virus Rta protein activates lytic cycle genes and can disrupt latency in B lymphocytes
25. Proteins specified by herpesvirus saimiri: Identification and properties in virus-specific polypeptides in productively infected cells
26. Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential regulation function
27. The acidic amino-terminal region of herpes simplex virus type 1 α protein ICP27 is required for an essential gene regulation function
28. Nucleotide sequences of the Kaposi sarcoma-associated herpesvirus (HHV8)
29. The Epstein-Barr virus nuclear protein SM is both a post-transcriptional inhibitor and activator of gene expression
30. ICP27 mediates herpes simplex virus nuclear export by shuttling through a leucine rich nuclear export signal and binding viral intronless RNAs through an RGG motif
31. The herpes simplex virus type 1 regulatory protein ICP27 coimmunoprecipitates with anti-Sm anti-serum and the C-terminus appears to be required for this interaction
32. The C-terminal repressor region of herpes simplex virus type 1 ICP27 is required for the redistribution of small nuclear ribonucleoprotein particles and splicing factor SC35; however, these alterations are not host cell splicing
33. Mta has properties of an RNA export protein and increases cytoplasmic accumulation of Epstein-Barr virus replication gene mRNA
34. Mutations in the activation region of herpes simplex virus regulatory protein ICP27 can be trans dominant
35. A viral gene that activates lytic cycle expression of the Kaposi's sarcoma-associated herpesvirus
36. The herpes simplex virus immediate early protein ICP27 encodes a potential metal binding domain and binds zinc in vitro
37. Complete sequence and genomic analysis of murine gammaherpesvirus 68
38. The multifunctional herpes simplex virus IE63 protein interacts with the heterogeneous ribonucleoprotein K and with casein kinase 2
39. The herpesvirus saimiri ORF 50 gene, encoding a major transcriptional activator homologous to the Epstein-Barr virus R protein, is transcribed from two distinct promoters of different temporal phases
40. Identification of a cis-acting element within the herpesvirus saimiri ORF6 promoter that is responsive to the HVS.R transactivator
41. The open reading frame (ORF) 50a gene product regulates ORF 57 gene expression in herpesvirus saimiri
42. The IE gene product encoded by ORF 57 of herpesvirus saimiri modulates gene expression at a post-transcriptional level
43. UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transcriptional activator
44. Epstein-Barr viral latency is disrupted by the immediate-early BRLF1 protein through a cell-specific mechanism
45. Self interaction of the herpes simplex type 1 regulatory protein ICP27