Psychopharmacology of 5-HT(1A) receptors

Nuclear Medicine and Biology

Volumn 27, Issue 5, 2000, Pages 437-439

  Cowen, Philip J ^a  

^a WARNEFORD HOSPITAL   (United Kingdom)

Author keywords

5 HT(1A) receptor; Depression; Neuroendocrine; Pindolol; SSRI

Indexed keywords

ANTIDEPRESSANT AGENT; GROWTH HORMONE; HYDROCORTISONE; IPSAPIRONE; PINDOLOL; PROLACTIN; SARCOLYSIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN UPTAKE INHIBITOR; TRYPTOPHAN;

BODY TEMPERATURE; DEPRESSION; GROWTH HORMONE BLOOD LEVEL; HORMONE RELEASE; HUMAN; HYDROCORTISONE BLOOD LEVEL; NEUROENDOCRINOLOGY; PROLACTIN BLOOD LEVEL; PSYCHOPHARMACOLOGY; RECEPTOR SENSITIVITY; REVIEW; TEMPERATURE SENSITIVITY;

EID: 0033827660     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(00)00108-6     Document Type: Article

References (25)

1. Anderson I.M., Deakin J.F.W., Miller A.T.J. The effects of chronic fluvoxamine on hormonal and psychological responses to buspirone in normal volunteers. Psychopharmacology. 128:1996;74-82.
2. Anderson I.M., Parry-Billings M., Newsholme E.A., Fairburn C.G., Cowen P.J. Dieting reduces plasma tryptophan and alters brain 5-HT function in women. Psychol. Med. 20:1990;785-791.
3. 1A antagonists. Trends Neurosci. 19:1996;378-383.
4. Barnes N.M., Sharp T. A review of 5-HT receptor subtypes and their function. Neuropharmacology. 38:1999;1083-1152.
5. Berman R.M., Darnell A.M., Miller H.L., Anand A., Charney D.S. Effect of pindolol in the hastening response to fluoxetine in the treatment of major depression A double-blind placebo-controlled trial . Am. J. Psychiatry. 154:1997;37-43.
6. Bill D.J., Knight M., Forster E.A., Fletcher A. Direct evidence for an important species difference in the mechanism of 8-OH-DPAT-induced hypothermia. Br. J. Pharmacol. 103:1991;1857-1864.
7. Blier P., de Montigny C. Current advances and trends in the treatment of depression. Trends Pharmac. Sci. 15:1994;220-226.
8. Bordet R., Thomas P., Dupuis B. Effect of pindolol on onset of action of paroxetine in the treatment of major depression Intermediate analysis of a double-blind, placebo-controlled trial . Am. J. Psychiatry. 155:1998;1346-1351.
9. Brewerton T.D., Mueller E.A., Lesem N.D., Brandt H.A., Quearry B., George T., Murphy D.L., Jimerson D.C. Neuroendocrine responses to m-chlorophenylpiperazine and l-tryptophan in bulimia. Arch. Gen. Psychiatry. 49:1992;852-861.
10. Cowen P. J. (1993) Serotonin receptor subtypes in depression: Evidence from studies in neuroendocrine regulation. Clin. Neuropharmacol. 16(suppl 3), S6-S18.
11. Cowen P.J. Neuroendocrine challenge tests What can we learn from them? Van de Kar L.D. Methods in Neuroendocrinology. 1998;205-223 CRC Press, Boca Raton, FL.
12. 1A receptor sensitivity in major depression: A neuroendocrine study with buspirone. Br. J. Psychiatry 164, 372-379.
13. 1A receptor antagonist and an SSRI in vivo: Effects on 5-HT cell firing and extracellular 5-HT. Br. J. Pharmacol. 115:1995;1064-1070.
14. 1A receptor responsivity in anxiety disorders and depression. Prog. Neuropsychopharmaco. Biol. Psychiatry. 15:1992;723-733.
15. 1A receptor responsivity in obsessive compulsive disorder. Psychopharmacology. 105:1991;415-420.
16. Meltzer H. Y., Gudelsky G. A., Lowy M. T., Nash J. F. and Koenig J. I. (1991) Neuroendocrine effects of buspirone: Mediation by dopaminergic and serotonergic mechanisms. In: Buspirone: Mechanisms and Clinical Aspects (Edited by Tunnicliff G, Eison AS, Taylor OP), pp. 177-192. Academic Press, San Diego, CA.
17. Meltzer H.Y., Maes M. Effects of ipsapirone on plasma cortisol and body temperature in major depression. Biol. Psychiatry. 38:1995;450-457.
18. Meltzer H.Y., Maes M. Effects of pindolol on hormone secretion and body temperature Partial agonist effects . J. Neural Transm. 103:1996;77-88.
19. Perez V., Gilaberte I., Faries D., Alvarez E., Artigas F. Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment. Lancet. 349:1997;1594-1597.
20. Power A.C., Cowen P.J. Neuroendocrine challenge tests Assessment of 5-HT function in anxiety and depression . Mol. Aspects Medicine. 13:1992;205-220.
21. Price L.H., Charney D.S., Delgado P.L., Anderson G.M., Heninger G.R. Effects of desipramine and fluvoxamine treatment on the prolactin response to tryptophan Serotonergic function and the mechanism of antidepressant action . Arch. Gen. Psychiatry. 46:1989;625-631.
22. 1A receptor sensitivity. Psychopharmacology. 132:1997;296-302.
23. 1A receptor activation by flesinoxan in humans Body temperature and neuroendocrine responses . Neuropsychopharmacology. 13:1995;93-104.
24. Shapira B., Newman M., Gelfin Y. and Lerer B. (2000) Blunted temperature and cortisol responses to ipsapirone in major depression: Lack of enhancement by electroconvulsive therapy. Psychoneuroendocrinology (in press).
25. Upadhyaya A.K., Pennell I., Cowen P.J., Deakin J.F.W. Blunted growth hormone and prolactin responses to L-tryptophan in depression A state-dependent abnormality . J. Affect. Disord. 21:1991;213-218.