Effect of paroxetine and nefazodone on 5-HT(1A) receptor sensitivity

Psychopharmacology

Volumn 132, Issue 3, 1997, Pages 296-302

  Sargent, P ^a   Williamson, D J ^a   Pearson, G ^a   Odontiadis, J ^a   Cowen, P J ^a  

^a Littlemore Mental Health Centre   (United Kingdom)

Author keywords

5 HT(1A) receptor; Gepirone; Nefazodone; Paroxetine

Indexed keywords

ANTIDEPRESSANT AGENT; AUTORECEPTOR; GEPIRONE; GROWTH HORMONE; HYDROCORTISONE; NEFAZODONE; PAROXETINE; PLACEBO; POSTSYNAPTIC RECEPTOR; PRESYNAPTIC RECEPTOR; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG SENSITIVITY; HORMONE RELEASE; HUMAN; HYPOTHERMIA; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR SENSITIVITY; VOLUNTEER;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BLOOD PLATELETS; DOUBLE-BLIND METHOD; HUMANS; HYDROCORTISONE; HYPOTHERMIA; MALE; MIDDLE AGED; PAROXETINE; PYRIMIDINES; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN UPTAKE INHIBITORS; TRIAZOLES;

EID: 0030877152     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050348     Document Type: Article

References (42)

1. 1A receptor: signalling, desensitisation and gene transcription. Neuropsychopharmacology 14:19-25
2. Anderson IM, Cowen PJ (1992) Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers. Psychopharmacology 106:428-432
3. Anderson IM, Cowen PJ, Grahame-Smith DG (1990) The effects of gepirone on neuroendocrine function and temperature in humans. Psychopharmacology 100:498-503
4. Andrade R, Nicoll RA (1987) Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J Physiol 394:99-124
5. Asberg M, Erikkson B, Matensson B, Traskman-Bendz L, Wagner A (1986) Therapeutic effects of serotonin uptake inhibitors in depression. J Clin Psychiatry 47:23-35
6. Blier P, de Montigny C (1994) Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15:220-226
7. Chaput Y, de Montigny C, Blier P (1986) Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat. Naunyn-Schmiedeberg's Arch Pharmacol 333:342-345
8. Chaput Y, Blier P, de Montigny C (1988) Acute and long-term effects of antidepressant 5-HT reuptake blocker on the efficacy of 5-HT neurotransmission: electrophysiological studies in the rat CNS. Adv Biol Psychiatry 17:1-17
9. Charney DS, Delgado PL, Southwick SM, Krystal JH, Price LH, Heninger GR (1991) Current hypotheses of the mechanism of antidepressant treatments: implications for the treatment of refractory depression. In: Amsterdam JD (ed) Advances in neuropsychiatry and psychopharmacology volume 2: refractory depression. Raven Press, New York, pp 23-40
10. Cowen PJ (1993) Serotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation. Clin Neuropharmacol 16 [Suppl 3]:S6-S18
11. Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Heninger GR (1990) Serotonin function and the mechanism of antidepressant action: reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 47:411-418
12. Eison AE, Yevich JP, Farney RF (1985) Gepirone hydrochloride. Drugs Future 10:456-457
13. 1A receptor activation in rats. Psychoneuroendocrinology 13: 471-478
14. Goodwin DM, De Souza RJ, Green AR (1985b) The pharmacology of the behavioural and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Psychopharmacology 91: 506-511
15. Goodwin GM, De Souza RJ, Green AR (1985c) Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock. Nature 317:531-533
16. 1 function. Neuropharmacology 24: 1187-1194
17. 1A receptor mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat. Psychopharmacology 91:500-505
18. 1A receptor regulation: effect of 5,7-dihydroxytryptamine and antidepressant treatments. Neuropsychopharmacology 4:131-144
19. Hillegaart V (1991) Effects of local application of 5-HT and 8-OH-DPAT into the dorsal and medial raphe on core temperature in the rat. Psychopharmacology 103:291-296
20. 1A agonists LY 165163 and 8-OH-DPAT is not prevented by 5-HT depletion. Eur J Pharmacol 143: 221-228
21. 1A autoregulatory control of 5-HT release in rat brain in vivo. J Neurosci Methods 34:91-98
22. Leonard BE (1996) The comparative pharmacological properties of selective serotonin re-uptake inhibitors in animals. In: Feighner JP, Boyer WF (eds) Selective serotonin re-uptake inhibitors: advances in basic research and clinical practice, 2nd edn. Wiley, Chichester, pp 36-62
23. 1A receptor responsivity in anxiety disorders in depression. Prog Neuropsychopharmacol Biol Psychiatry 15:723-733
24. 1A receptor responsivity in obsessive compulsive disorder. Psychopharmacology 105:415-420
25. 1A agonist 8-OH-DPAT in male rats. Brain Res 630:148-156
26. 1A agonist, ipsapirone, by long-term treatment with fluoxetine but not desipramine in male rats. Biol Psychiatry 36:300-308
27. Meltzer HY, Gudelsky GA, Lowy MT, Nash JF, Koenig JI (1991) Neuroendocrine effects of buspirone: mediation by dopaminergic and serotonergic mechanisms. In: Tunnicliff G, Eison AS, Taylor OP (eds) Buspirone: mechanisms and clinical aspects. Academic Press, San Diego, Calif., pp 177-192
28. Miller HL, Delgado PL, Salomon RM, Berman R, Krystal JH, Heninger GR, Charney DS (1996) Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression. Arch Gen Psychiatry 53:117-128
29. Molyneux SG, Clark EE (1985) Precise determination of 5-hydroxytryptamine in platelets and platelet-poor plasma. Clin Chem 31:1573-1574
30. Newman ME, Lerer B, Shapira B (1993) 5-HT-1A receptor-mediated effects of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 17:1-9
31. Price LH, Charney DS, Delgado PL, Anderson GM, Heninger GR (1989) Effects of desipramine and fluvoxamine treatment on the prolactin response to tryptophan. Arch Gen Psychiatry 46:625-631
32. Salazar DE, Chaikin PC, Swanson BN, Raymond RH (1994) The effects of nefazodone and fluoxetine on platelet serotonin uptake in whole blood serotonin. Clin Pharmacol Ther 55: P1-55
33. 1A receptor activation by flesinoxan in humans: body temperature and neuroendocrine responses. Neuropsychopharmacology 13:93-104
34. 1B agonists. Synapse 1:3-9
35. 1B agonists: a comparative study with dorsal raphe neurones. Neuropharmacology 27:707-715
36. Taylor DP, Carter RB, Eison AS, Mullins UL, Smith HL, Torrente JR, Wright RN, Yocca FD (1995) Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug. J Clin Psychiatry 56 [Suppl 6]:3-11
37. Tulloch IF, Johnson AM (1992) The pharmacological profile of paroxetine, a new selective serotonin reuptake inhibitor. J Clin Psychiatry 53 [Suppl 2]:7-12
38. Van de Kar LD (1991) The neuroendocrine pharmacology of serotonergic neurones. Annu Rev Pharmacol Toxicol 31: 289-320
39. Van de Kar LD, Li Q (1995) Oxytocin in neuroendocrine challenge tests of serotonergic function. Second International Conference on New Directions in Affective Disorders. Jerusalem. Abstract S115
40. 3H-imipramine binding, 5-HT uptake and 5-HT content in major depressive disorder. J Affect Disord 20:101-113
41. Welner SA, de Montigny C, Desroches J, Desjardins P, Suranyi-Cadotte BE (1989) Autoradiographic quantification of serotonin 1A receptors in rat brain following antidepressant drug treatment. Synapse 4:347-352
42. Willoughby JO, Menadue MF, Liebelt H (1987) Activation of serotonin receptors in the medial basal hypothalamus stimulates growth hormone secretion in the unanesthetized rat. Brain Res 404:319-322