Reduced expression of p27/Kip1 is associated with the development of pulmonary adenocarcinoma

Journal of Pathology

Volumn 192, Issue 1, 2000, Pages 26-31

  Hayashi, Hiroyuki ^a   Ito, Takaaki ^a   Yazawa, Takuya ^a   Ikeda, Masaichi ^a   Inayama, Yoshiaki ^a   Nakatani, Yukio ^a   Kameda, Yoichi ^b   Nakamura, Nobuo ^c   Kitamura, Hitoshi ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b KANAGAWA CANCER CENTER   (Japan)

^c YOKOHAMA MUNICIPAL CITIZEN'S HOSPITAL   (Japan)

Author keywords

Adenocarcinoma; Atypical adenomatous hyperplasia; Lung; P27 Kip1; Tumour development

Indexed keywords

KI 67 ANTIGEN; PROTEIN P27;

ADULT; AGED; ARTICLE; BRONCHUS MUCOSA; CORRELATION FUNCTION; FEMALE; HUMAN; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG ADENOMA; LUNG CARCINOGENESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; CELL CYCLE PROTEINS; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISEASE PROGRESSION; ENZYME INHIBITORS; HUMANS; HYPERPLASIA; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 0033824204     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9896(2000)9999:9999<::AID-PATH653>3.0.CO;2-V     Document Type: Article

References (33)

1. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
2. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest
3. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
4. p27Kip1: Chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors
5. Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies
6. Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias
7. Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting tumors
8. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
9. Increased proteasome dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
10. Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer
11. p27Kip1 in human lung cancers: Differential changes in small cell and non-small cell carcinomas
12. Reduced expression of the cell cycle inhibitor p27Kip1 in non-small cell lung carcinoma: A prognostic factor independent of Ras
13. Expression of cell cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
14. Transforming growth factor-β, transforming growth factor-β receptor II, and p27Kip1 expression in nontumorous and neoplastic human pituitaries
15. Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is associated with advanced stage and invasiveness of gastric carcinomas
16. High level expression of p27Kip1 and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27Kip1 and degree of malignancy in human breast and colorectal cancers
17. Reduced levels of the cell cycle inhibitor p27Kip1 in epithelial dysplasia and carcinoma of the oral cavity
18. Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma
19. p27kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
20. Atypical alveolar hyperplasia: Relationship with pulmonary adenocarcinoma, p53, and c-erbB-2 expression
21. Monoclonality of atypical adenomatous hyperplasia of the lung
22. Proliferative potential and p53 overexpression in precursor and early stage lesions of bronchioloalveolar lung carcinoma
23. Atypical adenomatous hyperplasia and bronchoalveolar lung carcinoma: Analysis by morphometry and the expressions of p53 and carcinoembryonic antigen
24. p53 alterations in atypical alveolar hyperplasia of the human lung
25. p21 RNA and protein expression in non-small cell lung carcinomas: Evidence of p53-independent expression and association with tumoral differentiation
26. Analysis of p21waf1/Cip1 expression in normal, premalignant, and malignant cells during the development of human lung adenocarcinoma
27. The World Health Organization histological typing of lung tumours. Second edition
28. Improved mRNA in situ hybridization on formaldehyde-fixed and paraffin-embedded tissue using signal amplification with different haptenized tyramides
29. Chromosomal mapping of members of cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer
30. Revisions in the international system for staging lung cancer
31. Active cyclin A-CDK2 complex, a possible critical factor for cell proliferation in human primary lung carcinomas
32. Role of p27Kip1 and cyclin-dependent kinase 2 in the proliferation of non-small cell lung cancer
33. Tumor extension and cell proliferation in adenocarcinoma of the lung