Cerebral histopathology following portal venous infusion of bacteria in a chronic porcine model

Anesthesiology

Volumn 93, Issue 3, 2000, Pages 793-804

  Bogdanski, Ralph ^a,d   Blobner, Manfred ^b   Becker, Ingrid ^c   Hänel, Frank ^b   Fink, Heidrun ^a   Kochs, Eberhard ^b  

^a Institut für Experimentelle Onkologie und Therapieforschung   (Germany)

^b Department of Anesthesiology   (Germany)

^c Inst Allg Pathol Pathologische A   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Brain damage; Cerebral oxygen balance; Cerebral perfusion pressure; Cytotoxic brain edema; Interleukin 6; Sepsis; Septic encephalopathy; Tumor necrosis factor

Indexed keywords

INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; BACTEREMIA; BRAIN EDEMA; BRAIN INJURY; BRAIN OXYGEN CONSUMPTION; BRAIN PERFUSION; CEREBROSPINAL FLUID EXAMINATION; CONTROLLED STUDY; CYTOTOXICITY; ESCHERICHIA COLI; FEMALE; HISTOPATHOLOGY; HYPOTENSION; HYPOXEMIA; INSTRUMENTATION; INTENSIVE CARE; NEUROPATHOLOGY; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEPSIS; SWINE;

EID: 0033822409     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200009000-00029     Document Type: Article

References (44)

1. Impact of encephalopathy on mortality in the sepsis syndrome: The Veterans Administration Systemic Sepsis Cooperative Study Group
2. The encephalopathy associated with septic illness
3. The electroencephalogram in sepsis-associated encephalopathy
4. Neurologic complications of critical medical illnesses
5. The role of hypotension in septic encephalopathy following surgical procedures
6. Brain neurotransmitter profile is deranged during sepsis and septic encephalopathy in the rat
7. Local cerebral glucose utilization in septic rats
8. Septic encephalopathy. Evidence for altered phenylalanine metabolism and comparison with hepatic encephalopathy
9. Cerebral blood flow is reduced in patients with sepsis syndrome
10. Early effects of E. coli endotoxin on superior sagittal sinus blood flow. An experimental study in dogs
11. Cerebral blood flow and oxygen uptake in endotoxic shock: An experimental study in dogs
12. Sepsis and cytokines: Current status
13. Sleep-promoting effects of endogenous pyrogen (interleukin-1)
14. Neuromuscular complications of sepsis
15. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
16. Endotoxin and lung injury
17. Evaluation of various cytokines (IL-6, IFN-alpha, IFN-gamma, TNF-alpha) as markers for acute bacterial infection in swine - A possible role for serum interleukin-6
18. Cytokine serum level during severe sepsis in human IL-6 as a marker of severity
19. Sepsis and serum cytokine concentrations
20. Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma
21. Brain damage complicating septic shock
22. The encephalopathy of sepsis
23. Thermal damage threshold of brain tissue - Histological study of heated normal monkey brains
24. Metabolic effects of cachectin/tumor necrosis factor are modified by site of production: Cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominantly acute anorexia
25. Tumor necrosis factor in the pathogenesis of infectious diseases
26. Multiple microabscesses in the central nervous system: A clinicopathologic study
27. Effect of vasopressors on organ blood flow during endotoxin shock in pigs
28. Cerebral circulation and norepinephrine: Relevance of the blood-brain barrier
29. Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat
30. Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice
31. Brain damage after profoundly hypothermic circulatory arrest: Correlations between neurophysiologic and neuropathologic findings. An experimental study in vertebrates
32. Clinical use of mild hypothermia for brain protection: A dream revisited
33. Permeability of the blood-brain and blood-spinal cord barriers to interferons
34. Murine tumor necrosis factor alpha is transported from blood to brain in the mouse
35. Induction of cytokine transcripts in the central nervous system and pituitary following peripheral administration of endotoxin to mice
36. Die Rolle des Zytokinnetzwerks im ZNS und psychische Storungen
37. Effect of recombinant human tumor necrosis factor-alpha on cerebral oxygen uptake, cerebrospinal fluid lactate, and cerebral blood flow in the rabbit: Role of nitric oxide
38. Tumor necrosis factor and regulation of metabolism in infection: Role of systemic versus tissue levels
39. PAF and TNF alpha interactions in the pathophysiology of septic shock
40. Effects of tumor necrosis factor-alpha and interleukin-6 on fluid-phase permeability and ammonia diffusion in CNS-derived endothelial cells
41. Brain edema
42. Pathological immuno-reactions of glial cells in Alzheimer's disease and possible sites of interference
43. Loss of NF-kappaB activity during cerebral ischemia and TNF cytotoxicity