Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution in children and adolescents

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 3, 1999, Pages 634-638

  Kearns, Gregory L ^a,b,c   Abdel Rahman, Susan M ^a,b,c   James, Laura P ^d,e   Blowey, Douglas L ^a,b,c   Marshall, James D ^a,b,c   Wells, Thomas G ^d,e   Jacobs, Richard F ^d,e  

^a CHILDREN S MERCY HOSPITAL   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^d ARKANSAS CHILDREN S HOSPITAL   (United States)

^e UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLECONARIL;

AREA UNDER THE CURVE; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG PENETRATION; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; VIRUS INFECTION;

EID: 0032978905     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.3.634     Document Type: Article

References (11)

1. Abdel-Rahman, S. M., and G. L. Kearns. 1998. Single dose pharmacokinetics of pleconaril (VP63843) oral suspension and the effect of prandial state. Antimicrob. Agents Chemother. 42:2706-2709.
2. Abzug, M. J., H. L. Keyserling, M. L. Lee, M. J. Levin, and H. A. Rotbart. 1995. Neonatal enterovirus infection: virology, serology, and effects of intravenous immune globulin. Clin. Infect. Dis. 20:1201-1206.
3. Berlin, L. E., M. L. Rorabaugh, F. Heldrich, K. Roberts, T. Doran, and J. F. Modlin. 1993. Aseptic meningitis in infants <2 years of age: diagnosis and etiology. J. Infect. Dis. 168:888-892.
4. Dagan, R. 1996. Nonpolio enterovirus and the febrile young infant: epidemiologic, clinical and diagnostic aspects. Pediatr. Infect. Dis. J. 15:67-71.
5. Keyserling, H. L. 1997. Other viral agents of perinatal importance: varicella, parvovirus, respiratory syncytial virus, and enterovirus. Clin. Perinatol. 24: 193-211.
6. McKinlay, M. A., D. C. Pevear, and M. G. Rossmann. 1992. Treatment of the picornavirus common cold by inhibitors of viral uncoating and attachment. Annu. Rev. Microbiol. 46:635-645.
7. Phoenix International Life Sciences. 1996. Validation of a high resolution gas Chromatographic method for the determination of VP 63843 in human plasma by electron capture detection. Phoenix Project no. 952145/EJN. Phoenix International Life Sciences, Montreal, Quebec, Canada.
8. Rotbart, H. A. 1995. Enteroviral infections of the central nervous system. Clin. Infect. Dis. 20:971-981.
9. Strikas, R. A., L. J. Anderson, and R. A. Parker. 1986. Temporal and geographic patterns of isolates of nonpolio enterovirus in the United States, 1970-1983. J. Infect. Dis. 153:346-351.
10. Thoren, A., and A. Widell. 1994. PCR for the diagnosis of enteroviral meningitis. Scand. J. Infect. Dis. 26:249-254.
11. ViroPharma Incorporated. VP63843 Clinical Investigators Brochure. ViroPharma Incorporated. Malvern, Pa.