A probing dose of phenylacetate does not affect glucose production and gluconeogenesis in humans

Metabolism: Clinical and Experimental

Volumn 49, Issue 9, 2000, Pages 1211-1214

  Wajngot, A ^a   Chandramouli, V ^a   Schumann, W C ^a   Brunengraber, H ^a   Efendic, S ^a   Landau, B R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACARBOSE; ANTIDIABETIC AGENT; DEUTERIUM; GLUCOSE; ISOPHANE INSULIN; METFORMIN; PHENYLACETIC ACID; SULFONYLUREA DERIVATIVE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CITRIC ACID CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HUMAN; ISOTOPE LABELING; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

EID: 0033817948     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1053/meta.2000.8601     Document Type: Article

References (25)

1. Phenylacetylglutamin und seine bilding im menschlichen Korper nach eingabe von phenylessigsaure
2. Further studies on the detoxification of phenylacetic acid
3. Urea cycle disorders: Diagnosis, pathophysiology, and therapy
4. Long-term survival of patients with argininosuccinate synthetase deficiency
5. Long-term treatment of girls with ornithine transcarbamylase deficiency
6. Waste nitrogen excretion via amino acid acylation: Benzoate and phenylacetate in lysinuric protein intolerance
7. Noninvasive tracing of Krebs cycle metabolism in liver
8. 14C-labeled propionate metabolism in vivo and estimates of hepatic gluconeogenesis relative to Krebs cycle flux
9. 13C]propionate, phenylacetate, and acetaminophen
10. Estimates of Krebs cycle activity and contributions of gluconeogenesis to hepatic glucose production in fasting healthy subjects and IDDM patients
11. 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus
12. Non-invasive tracing of liver in moderately hyperglycaemic NIDDM subjects. Evidence against increased gluconeogenesis and hepatic fatty acid oxidation in NIDDM
13. Non-invasive probing of liver citric acid cycle intermediates with phenylacetylglutamine
14. Inhibition of gluconeogenesis in the isolated perfused rat liver by ω-phenylalkanoic acids
15. In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase
16. Quantifying gluconeogenesis during fasting
17. Contributions of gluconeogenesis to glucose production in the fasted state
18. 3H-glucose infusion
19. The hyperphenyl-alaninemias
20. Coated charcoal immunoassay of insulin
21. Glucagon radioimmunoassay
22. Assay of the human liver citric acid cycle probe phenylacetylglutamine and of phenylacetate in plasma by gas chromatography-mass spectrometry
23. The conjugation of phenylacetic acid in man, sub-human primates and some non-primate species
24. Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis