Concurrence of replicative senescence and elevated expression of p16(INK4A) with subculture-induced but not calcium-induced differentiation in normal human oral keratinocytes

Archives of Oral Biology

Volumn 45, Issue 10, 2000, Pages 809-818

  Lee, Gene ^a   Park, Beom Seok ^a   Han, Song Ee ^a   Oh, Ju Eun ^a   You, Yong Ouk ^a   Baek, Jeong Hwa ^a   Kim, Gwan Shik ^a   Min, Byung Moo ^a  

^a School of Dentistry   (South Korea)

Author keywords

Calcium induced differentiation; Normal human oral keratinocytes; p16(INK4A); Replicative senesence; Subculture induced differentiation

Indexed keywords

BETA GALACTOSIDASE; CALCIUM; INVOLUCRIN; PROTEIN P16; PROTEIN P53; PROTEIN PRECURSOR; TELOMERASE;

ADULT; ARTICLE; CELL AGING; CELL CULTURE; CELL DIFFERENTIATION; CELL DIVISION; CONTROLLED STUDY; CYTOLOGY; ENZYME ACTIVITY; EPITHELIUM CELL; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; MITOSIS; MOUTH MUCOSA; NORMAL HUMAN; SENESCENCE; TUMOR SUPPRESSOR GENE;

BETA-GALACTOSIDASE; CALCIUM; CELL AGING; CELL DIFFERENTIATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYTOLOGICAL TECHNIQUES; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENES, P16; GENES, P53; HUMANS; KERATINOCYTES; MITOSIS; MOUTH MUCOSA; PROTEIN PRECURSORS; TELOMERASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033816193     PISSN: 00039969     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9969(00)00061-3     Document Type: Article

References (39)

1. Increased activity of p53 in senescing fibroblasts
2. Three clonal types of keratinocyte with different capacities for multiplication
3. Epidermal growth factor receptor expression related to differentiation capacity in normal and transformed keratinocytes
4. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
5. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
6. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
7. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
8. Regulation of p16(CDKN2) expression and its implications for cell immortalization and senescence
9. Telomere loss: Mitotic clock or genetic time bomb?
10. The telomere hypothesis of cellular aging
11. Calcium regulation of cell-cell contact and differentiation of epidermal cells in culture: An ultrastructural study
12. Intracellular calcium alterations in response to increased external calcium in normal and neoplastic keratinocytes
13. Calcium regulation of growth and differentiation of mouse epidermal cells in culture
14. Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells
15. Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres
16. Specific association of human telomerase activity with immortal cells and cancer
17. Differences in the regulation of intracellular calcium in normal and neoplastic keratinocytes are not caused by ras gene mutations
18. Modulation of tissue and epidermal transglutaminases in mouse epidermal cells after treatment with 12-O-tetradecanoylphorbol-13-acetate and/or retinoic acid in vivo and in culture
19. Association of CDKN2A/p16(INK4A) with human head and neck keratinocyte replicative senescence: Relationship of dysfunction to immortality and neoptasia
20. p53 is required for radiation-induced apoptosis in mouse thymocytes
21. Keratinocytes become terminally differentiated in a process involving programmed cell death
22. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
23. p21(WAF1/C1P1) expression correlates with calcium-induced differentiation in normal human oral keratinocytes
24. Malignant transformation of HPV-immortalized human oral keratinocytes by chemical carcinogens
25. Terminal differentiation of normal human oral keratinocytes is associated with enhanced cellular TGF-β and phospholipase C-γl levels and apoptotic cell death
26. Immortalization of normal human oral keratinocytes with type 16 human papillomavirus
27. The genetic basis of human keratinocyte immortalization in squamous cell carcinoma development: The role of telomerase reactivation
28. Calcium regutation of growth and differentiation of normal human keratinocytes: Modulation of differentiation competence by stages of growth and extracellular calcium
29. Social controls on cell survival and cell death
30. c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms
31. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a)
32. An increase in intracellular free calcium is an early event during differentiation of cultured human keratinocytes
33. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line
34. 1 arrest in senescent human fibroblasts
35. Increase in expression level of p21(sdi1/cip1/waf1) with increasing division age in both normal and SV40-transformed human fibroblasts
36. The control of cutaneous development and behavior
37. Analysis of p16(INK4a) and its interaction with CDK4
38. Expression of routine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro
39. The regulation of differentiation in normal and neoplastic keratinocytes