Potent block of volume-activated chloride currents in endothelial cells by the uncharged form of quinine and quinidine

British Journal of Pharmacology

Volumn 118, Issue 7, 1996, Pages 1869-1871

  Voets, Thomas ^a   Droogmans, Guy ^a   Nilius, Bernd ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Endothelium; Patch clamp; Quinidine; Quinine; Volume activated chloride current

Indexed keywords

CHLORIDE CHANNEL BLOCKING AGENT; CHLORIDE ION; QUINIDINE; QUININE;

ANIMAL CELL; ARTICLE; CHLORIDE CURRENT; CONTROLLED STUDY; ENDOTHELIUM CELL; NONHUMAN; PATCH CLAMP; PH; PRIORITY JOURNAL; PULMONARY ARTERY; VASCULAR ENDOTHELIUM;

EID: 0029933998     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15616.x     Document Type: Article

References (20)

1. - channels in MDCK cells during volume regulation in hypotonic media. J. Membr. Biol., 126, 219-234.
2. CHOU, C.Y., SHEN, M.R. & WU, S.N. (1995). Volume-sensitive chloride channels associated with human cervical carcinogenesis. Cancer Res., 55, 6077-6083.
3. FURMAN HARAN, E., MARETZEK, A.F., GOLDBERG, L, HOROWITZ, A. & DEGANI, H. (1994). Tamoxifen enhances cell death in implanted MCF7 breast cancer by inhibiting endothelium growth. Cancer Res., 54, 5511-5514.
4. HEINKE, S., SZÜCS, G., NORRIS, A., DROOGMANS, G. & NILIUS, B. (1995). Inhibition of volume-activated chloride channels in endothelial cells by chromones. Br. J. Pharmacol., 115, 1393-1398.
5. HOFFMANN, E.K. & SIMONSEN, L.O. (1989). Membrane mechanisms in volume and pH regulation in vertebrate cells. Physiol. Rev., 69, 315-382.
6. KIRK, K. & KIRK, J. (1993). Volume-regulatory taurine release from a human lung cancer cell line. Evidence for amino acid transport via a volume-activated chloride channel. FEBS Lett., 336, 153-158.
7. KURIYAMA, H., KITAMURA, K. & NABATA, H. (1995). Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues. Pharmacol. Rev., 47, 387-573.
8. --channels. Gen. Pharmacol., (in press).
9. - current by hypotonic volume increase in human endothelial cells. J. Gen. Physiol., 103, 787-805.
10. - channels. J. Physiol., 487, 367-378.
11. --currents in human endothelial cells. Br. J. Pharmacol., 12, 1049-1056.
12. - currents in different mammalian non-excitable cell types. Pflügers Arch., 428, 364-371.
13. 2+ transients in endothelial cells from human umbilical vein. Proc. Natl. Acad. Sci. U.S.A., 91, 2940-2944.
14. SANDFORD, C.A., SWEIRY, J.H. & JENKINSON, D.H. (1992). Properties of a cell volume-sensitive potassium conductance in isolated guinea-pig and rat hepatocytes. J. Phvsiol., 447, 133-148.
15. SARKADI, B. & PARKER, J.C. (1991). Activation of ion transport pathways by changes in cell volume. Biochim. Biophys. Acta, 1071, 407-427.
16. SCHUMACHER, P.A., SAKELLAROPOULOS, G., PHIPPS, D.J. & SCHLICHTER, L.C. (1995). Small-conductance chloride channels in human peripheral T lymphocytes. J. Membr. Biol., 145, 217-232.
17. SZÜCS, G., BUYSSE, G., EGGERMONT, J., DROOGMANS, G. & NILIUS, B. (1996). Characterisation of volume-activated chloride currents in endothelial cells from bovine pulmonary artery. J. Membr. Biol., 147, 189-197.
18. VERDON, B., WINPENNY, J.P., WHITFIELD, K.J., ARGENT, B.E. & GRAY, M.A. (1995). Volume-activated chloride currents in pancreatic duct cells. J. Membr. Biol., 147, 173-183.
19. - currents inhibit endothelial cell proliferation. Pflügers Arch., 431, 132-134.
20. VÖLKL, H., BUSCH, G.L., HÄUSSINGER, D. & LANG, F. (1994). Alkalinization of acidic cellular compartments following cell swelling. FEBS Lett., 338, 27-30.