Effects of diltiazem on human nicotinic acetylcholine and GABA(A) receptors

Neuropharmacology

Volumn 39, Issue 13, 2000, Pages 2533-2542

  Houlihan, L M ^a   Slater, E Y ^a   Beadle, D J ^a   Lukas, R J ^b   Bermudez, I ^a  

^a OXFORD BROOKES UNIVERSITY   (United Kingdom)

^b BARROW NEUROLOGICAL INSTITUTE   (United States)

Author keywords

4 2 Receptors; 7 Receptors; Diltiazem; Muscle nicotinic acetylcholine receptors; Neuronal nicotinic acetylcholine receptors; Verapamil; Xenopus oocytes

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BUNGAROTOXIN; DILTIAZEM; NICOTINIC RECEPTOR; VERAPAMIL;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM CHANNEL; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; IC 50; MUSCLE; NEUROBLASTOMA CELL; OOCYTE; PRIORITY JOURNAL; XENOPUS LAEVIS;

BINDING SITES; BINDING, COMPETITIVE; BUNGAROTOXINS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELL LINE; DILTIAZEM; ELECTROPHYSIOLOGY; HUMAN; INDICATORS AND REAGENTS; IODINE RADIOISOTOPES; RECEPTORS, GABA-A; RECEPTORS, NICOTINIC; VERAPAMIL;

EID: 0033809534     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00116-7     Document Type: Article

References (19)

1. Pharmacological characterization of α-bungarotoxin-sensitive acetylcholine receptors immunoisolated from chick retina: contrasting properties of α7 and α8 subunit-containing subtypes
2. Neuronal nicotinic acetylcholine receptors on bovine chromaffin cells: cloning, expression and genomic organization of receptor subunits
3. Molecular and cellular mechanisms of general anaesthesia
4. Separation of two pathways for calcium entry into chromaffin cells
5. Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by diltiazem
6. Modulation of nicotinic acetylcholine receptors by strychnine
7. α-bungarotoxin-sensitive nicotinic receptors on bovine chromaffin cells: molecular cloning, functional expression and alternative splicing of the α7 subunit
8. 2+ channels
9. 7 neuronal nicotinic receptors by ω-conotoxin MVIIC, ω-conotoxin GVIA and diltiazem
10. The nicotinic acetylcholine receptor of the bovine chromaffin cell, a new target for dihydropyridines
11. Unmasking the functions of the chromaffin cell α7 nicotinic receptor by using short pulses of acetylcholine and selective blockers
12. Up-regulation of human α7 nicotinic receptors by chronic treatment with activator and antagonist ligands
13. Chronic nicotine exposure differentially affects the function of human α3, α4 and α7 neuronal nicotinic receptor subtypes
14. Inducible, heterologous expression of human α7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line
15. Chronic nicotine treatment up-regulates α3 and α7 acetylcholine receptor subtypes expressed by the human neuroblastoma cell line SH-SY5Y
16. Human α7 acetylcholine receptor: cloning of the α7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional α7 homomers expressed in Xenopus oocytes
17. Functional expression of nicotinic acetylcholine receptors containing rat α7 subunits in human SH-SY5Y neuroblastoma cells
18. 2+ channels of chromaffin cells
19. Steady-state plasma concentration of diltiazem and its metabolites in patients and healthy volunteers