Antibody production and engineering in plants

Annals of the New York Academy of Sciences

Volumn 792, Issue , 1996, Pages 72-81

  Ma, Julian K C ^a   Hein, Mich B ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY;

ANTIBODY PRODUCTION; CONFERENCE PAPER; GENETIC ENGINEERING; IMMUNOTHERAPY; NONHUMAN;

EID: 0029837406     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb32493.x     Document Type: Conference Paper

References (35)

1. MOFFAT, A. S. 1995. Exploring transgenic plants as a new vaccine source. Science 268: 658-660.
2. HIATT, A. C., R. CAFFERKEY & K. BOWDISH. 1989. Production of antibodies in transgenic plants. Nature 342: 76-78.
3. HOLLIGER, P., T. PROSPERO & G. WINTER. 1993. "Diabodies": Small bivalent and bispecific antibody fragments. Proc. Natl. Acad. Sci. USA 90: 6444-6448.
4. DURING, K., S. HIPPE, F. KREUZALER & J. SCHELL. 1990. Synthesis and self assembly of a functional antibody in transgenic Nicotiana tabacum. Plant Mol. Biol. 15: 281-293.
5. MA, J. K-C., T. LEHNER, P. STABILA, C. I. FUX & A. HIATT. 1994. Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants. Eur. J. Immunol. 24: 131-138.
6. GETHING, M. J. & J. SAMBROOK. 1992. Protein folding in the cell. Nature 355: 33-45.
7. MELNICK, J., S. AVIEL & Y. ARGON. 1992. The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains. J. Biol. Chem. 267: 21303-21306.
8. HEIN, M. B., Y. TANG, D. A. MCLEOD, K. D. JANDA & A. C. HIATT. 1991. Evaluation of immunoglobulins from plant cells. Biotechnol. Prog. 7: 455-461.
9. FONTES, E. B. P., B. B. SHANK, R. L. WROBEL, S. P. MOOSE, G. R. O'BRIAN, E. T. WURTZEL & R. S. BOSTON. 1991. Characterization of an immunoglobulin binding-protein homolog in the maize floury-2 endosperm mutant. Plant Cell 3: 483-496.
10. WALTHER-LARSEN, H., J. BRANDT, D. B. COLLINGE & H. THORDAL-CHRISTENSEN. 1993. A pathogen-induced gene of barley encodes a HSP90 homologue showing striking similarity to vertebrate forms resident in the endoplasmic reticulum. Plant Mol. Biol. 21: 1097-1108.
11. DENECKE, J., M. H. GOLDMAN, J. DEMOLDER, J. SEURINCK & J. BOTTERMAN. 1991. The tobacco luminal binding protein is encoded by a multigene family. (Published erratum appears in Plant Cell. 1991. 3: 1251.) Plant Cell 3: 1025-1035.
12. STURM, A., J. A. VAN KUIK, J. F. VLIEGENTHART & M. J. CHRISPEELS. 1987. Structure, position, and biosynthesis of the high mannose and the complex oligosaccharide side chains of the bean storage protein phaseolin. J. Biol. Chem. 262: 13392-13403.
13. FAYE, L., K. D. JOHNSON, A. STURM & M. J. CHRISPEELS. 1989. Structure, biosynthesis and function of asparagine-linked glycans on plant glycoproteins. Physiol. Plant. 75: 309-314.
14. JONES, R. L & D. G. ROBINSON. 1989. Tansley review No-17 protein secretion in plants. New Phytol. 111: 567-597.
15. VON SCHAEWEN, A., A. STURM, J. O'NEILL & M. J. CHRISPEELS. 1993. Isolation of a mutant arabidopsis plant that lacks N-acetyl glucosaminyl transferase I and is unable to synthesise Golgi-modified complex N-linked glycans. Plant Physiol. 102: 1109-1118.
16. FIREK, S., J. DRAPER, M. R. L. OWEN, A. GANDECHA, B. COCKBURN & G. C. WHITELAM. 1993. Secretion of a functional single-chain Fv protein in transgenic tobacco plants and cell suspension cultures. Plant Mol. Biol. 23: 861-870.
17. BIRD, R. E., K. D. HARDMAN, J. W. JACOBSON, S. JOHNSON, B. M. KAUFMAN, S. M. LEE, T. LEE, S. H. POPE, G. S. RIORDAN & M. WHITLOW. 1988. Single-chain antigen-binding proteins. Science 242: 423-426.
18. WARD, E. S., D. GUSSOW, A. D. GRIFFITHS, P. T. JONES & G. WINTER. 1989. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature 341: 544-546.
19. NISSIM, A., H. R. HOOGENBOOM, I. M. TOMLINSON, G. FLYNN, C. MIDGLEY, D. LANE & G. WINTER. 1994. Antibody fragments from a 'single pot' phage display library as immunochemical reagents. EMBO J. 13: 692-698.
20. BENVENUTO, E., R. J. ORDAS, R. TAVAZZA, G. ANCORA, S. BIOCCA, A. CATTANEO & P. GALEFFI. 1991. 'Phytoantibodies': A general vector for the expression of immunoglobulin domains in transgenic plants. Plant Mol. Biol. 17: 865-874.
21. OWEN, M., A. GANDECHA, B. COCKBURN & G. WHITELAM. 1992. Synthesis of a functional anti-phytochrome single chain Fv protein in transgenic tobacco. Biotechnology 10: 790-794.
22. TAVLADORAKI, P., E. BENVENUTO, S. TRINCA, D. DE MARTINIS, A. CATTANEO & P. GALEFFI. 1993. Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack. Nature 366: 469-472.
23. DE NEVE, M., M. DE LOOSE, A. JACOBS, H. VAN HOUDT, B. KALUZA, U. WEIDLE & A. DEPICKER. 1993. Assembly of an antibody and its derived antibody fragment in Nicotiana and Arabidopsis. Transgenic Res. 2: 227-237.
24. VAN ENGELEN, F. A., A. SCHOUTEN, J. W. MOLTHOFF, J. ROOSIEN, J. SALINAS, W. G. DIRKSE, A. SCHOTS, J. BAKKER, F. J. GOMMERS, M. A. JONGSMA et al. 1994. Coordinate expression of antibody subunit genes yields high levels of functional antibodies in roots of transgenic tobacco. Plant Mol. Biol. 26: 1701-1710.
25. MA, J. K-C., A. HIATT, M. B. HEIN, N. VINE, F. WANG, P. STABILA, C. VAN DOLLEWEERD, K. MOSTOV & T. LEHNER. 1995. Generation and assembly of secretory antibodies in plants. Science 268: 716-719.
26. MOSTOV, K. E. 1994. Transepithelial transport of immunoglobulins. Ann. Rev. Immunol. 12: 63-84.
27. HIATT, A. 1990. Antibodies produced in plants. Nature 344: 469-470.
28. LEHNER, T., J. CALDWELL & R. SMITH. 1985. Local passive immunization by monoclonal antibodies against streptococcal antigen I/II in the prevention of dental caries. Infect. Immun. 50: 796-799.
29. BESSEN, D. & V. A. FISCHETTI. 1988. Passive acquired mucosal immunity to group A streptococci by secretory immunoglobulin A. J. Exp. Med. 167: 1945-1950.
30. MA, J. K-C., M. HUNJAN, R. SMITH, C. KELLY & T. LEHNER. 1990. An investigation into the mechanism of protection by local passive immunisation with monoclonal antibodies against Streptococcus mutans. Infect. Immun. 58: 3407-3414.
31. RUSSELL, M. W. & H. Y. WU. 1991. Distribution, persistence, and recall of serum and salivary antibody responses to peroral immunization with protein antigen I/II of Streptococcus mutans coupled to the cholera toxin B subunit. Infect. Immun. 59: 4061-4070.
32. WINNER, L., J. MACK, R. WELTZIN, J. J. MEKALANOS, J. P. KRAEHENBUHL & NEUTRAMR. 1991. New model for analysis of mucosal immunity: Intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection. Infect. Immun. 59: 977-982.
33. MICHALEK, S. M., R. L. GREGORY, C. C. HARMON, J. KATZ, G. J. RICHARDSON, T. HILTON, S. J. FILLER & J. R. MCGHEE. 1987. Protection of gnotobiotic rats against dental caries by passive immunization with bovine milk antibodies to Streptococcus mutans. Infect. Immun. 55: 2341-2347.
34. HAMADA, S., T. HORIKOSHI, T. MINAMI, S. KAWABATA, J. HIRAOKA, T. FUJIWARA & T. OOSHIMA. 1991. Oral passive immunisation against dental caries in rats by use of hen egg yolk antibodies specific for cell associated glucosyltransferase of Streptococcus mutans. Infect. Immun. 59: 4161-4167.
35. HAQ, T. A., H. S. MASON, J. D. CLEMENTS & C. J. ARNTZEN. 1995. Oral immunization with a recombinant bacterial antigen produced in transgenic plants. Science 268: 714-716.