Heavy metal cytotoxicity studied by electron probe X-ray microanalysis of cultured rat hepatocytes

Toxicology in Vitro

Volumn 14, Issue 6, 2000, Pages 557-563

  Zierold, K ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

Cryosection; Cytotoxicity; Heavy metal; Hepatocyte; Intracellular ions; X ray microanalysis

Indexed keywords

COPPER; GOLD; HEAVY METAL; LEAD; MERCURY; SULFUR; THALLIUM; ZINC;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; LIVER CELL; MICROANALYSIS; NONHUMAN; POTASSIUM CELL LEVEL; RAT; SODIUM CELL LEVEL; TECHNIQUE; X RAY MICROANALYSIS;

ANIMAL; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; CHLORIDES; CYTOPLASM; ELECTRON PROBE MICROANALYSIS; HEPATOCYTES; MALE; METALS, HEAVY; MICROSCOPY, ELECTRON, SCANNING; POTASSIUM; RATS; RATS, WISTAR; SODIUM;

EID: 0033800125     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(00)00049-7     Document Type: Article

References (37)

1. Altered plasma membrane ion permeability in mercury-induced cell injury; Studies in hepatocytes of elasmobranch Raja Erinacea
2. Criteria of viability of isolated liver cells
3. Anoxic hepatocyte injury; role of reversible changes in elemental content and distribution
4. +-ATPase in rat liver plasma membrane and signal transduction
5. Intranuclear dense bodies after metal intoxication; A review of ultrastructural and microanalytical findings
6. 2 (PM)
7. 2+
8. Heavy metal intracellular balance and relationship with metallothionein induction in the liver of carp after contamination by silver, cadmium and mercury following or not pretreatment by zinc
9. Further evidence for zinc as a hepatoprotective agent in rat liver toxicity
10. The cell water problem posed by electron microscopic studies of ion binding in muscle
11. Toxicity testing with hepatocytes; Some methodological aspects
12. Thallium toxicity
13. Use of hepatocyte cultures for the study of hepatotoxic compounds
14. Metallothionein
15. Injectable gold compounds-an overview
16. Antitumor effect of gold as revealed by growth suppression of cultured cancer cells
17. The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocytes
18. Rat hepatocytes with elevated metallotionein expression are resistant to N-methyl-N'-nitro-N-nitrosoguanidine cytotoxicity
19. Toxic injury from mercuric chloride in rat hepatocytes
20. Mercury chloride toxicity in rat liver mitochondria and isolated hepatocytes
21. Reduction in porphyrin excretion as a sensitive indicator of lead toxicity in primary cultures of adult rat hepatocytes
22. Cell membranes as site of action of heavy metals
23. Metalle
24. Fine structure of hepatocytes during the etiology of several common pathologies
25. Disease-modifying antirheumatic drugs
26. Comparison of the effects of metals on cellular injury and lipid peroxidation in isolated rat hepatocytes
27. Comparative studies on the toxicity of mercury, cadmium and copper toward the isolated perfused liver
28. The relationship between cellular ion deregulation and acute and chronic toxicity
29. Cultured hepatocytes as investigational models for hepatic toxicity; practical applications in drug discovery and development
30. Biochemical effects of mercury, cadmium and lead
31. Nucleocytoplasmic functionality of metallothionein
32. X-ray microanalysis of freeze-dried and frozen-hydrated cryosections
33. Effects of cadmium on electrolyte ions in cultured rat hepatocytes studied by X-ray microanalysis of cryosections
34. Characterization of a primary hepatocyte culture system for toxicological studies