Comparative studies on the toxicity of mercury, cadmium, and copper toward the isolated perfused rat liver

Journal of Toxicology and Environmental Health - Part A

Volumn 47, Issue 3, 1996, Pages 267-283

  Strubelt, O ^a   Kremer, J ^a   Tilse, A ^a   Keogh, J ^a   Pentz, R ^a   Younes, M ^b  

^a UNIVERSITY OF LÜBECK   (Germany)

^b WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALBUMIN; ANTIOXIDANT; CADMIUM; CATALASE; COPPER; GLUTATHIONE; MALONALDEHYDE; MERCURY; PROTECTIVE AGENT; SUPEROXIDE DISMUTASE; TROLOX C;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ISOLATED LIVER; LIPID PEROXIDATION; LIVER PERFUSION; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ALBUMINS; ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; BILE; CADMIUM; CALCIUM; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; L-LACTATE DEHYDROGENASE; LIVER; MALE; MALONDIALDEHYDE; MERCURY; OXYGEN CONSUMPTION; PERFUSION; RATS; REACTIVE OXYGEN SPECIES;

EID: 0030024796     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/009841096161780     Document Type: Review

References (40)

1. Ballatori, N., Shi, C., and Boyer, J. L. 1988. Altered plasma membrane ion permeability in mercury-induced cell injury: Studies in hepatocytes of elasmobranch raja erinacea. Toxicol. Appl. Pharmacol. 95:279-291.
2. Brehe, J. E., and Burch, H. B. 1976. Enzymatic assay for glutathione. Anal. Biochem. 74:189-197.
3. Buege, J. A., and Aust, S. D. 1978. Microsomal lipid peroxidation. Methods Enzymol. 52:302-310.
4. Chan, H. M., and Cherian, M. G. 1992. Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium. Toxicology 72:281-290.
5. 2+. J. Biol. Chem. 263:3582-3587.
6. Costa, M., Christie, N. T., Cantoni, O., Zelikoff, J. T., Wand, X. W., and Rossman, T. G. 1991. DNA damage by mercury compounds: An overview. In Advances in mercury toxicology, ed. T. Suzuki, N. Imura, and T. W. Clarkson, pp. 255-273. New York: Plenum Press.
7. Dillard, C. J., and Tappel, A. L. 1984. Lipid peroxidation and copper toxicity in rats. Drug Chem. Toxicol. 7:477-487.
8. Dougherty, J. J., and Hoekstra, W. G. 1982. Effects of vitamin E and selenium on copper-induced lipid peroxidation in vivo and on acute copper toxicity. Proc. Soc. Exp. Biol. Med. 169:201-208.
9. Dunnett, C. W. 1964. New tables for multiple comparisons with a control. Biometrics 20:482-491.
10. Eife, R., Reiter, K., Siegmund, B., Schramel, P., Dieter, H., and Müller-Höcker, H. 1991. Die frühkindliche Leberzirrhose als Folge der chronischen Kupferintoxikation. Bundesgesundheitsblatt 34:327-329.
11. Friberg, L., Piscator, M., Nordberg, G. F., and Kjellström, T. 1974. Cadmium in the environment, 2nd ed. Cleveland, OH: CRC Press.
12. Griffith, O. W. 1980. Determination of glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106:207-212.
13. Halbach, S. 1989. Sulfhydryl-induced restoration of myocardial contractility after alteration by mercury. Arch. Toxicol. Suppl. 13:349-352.
14. Halliwell, B. 1989. Current status review: Free radicals, reactive oxygen species and human disease: A critical evaluation with special reference to atherosclerosis. Br. J. Exp. Pathol. 70:737-757.
15. Hoffmann, E. O., Cook, J. A., DiLuzio, N. R., and Coover, J. A. 1975. The effects of acute cadmium administration in the liver and kidney of the rat; light and electron microscopic studies. Lab. Invest. 32:655-664.
16. Kappus, H., and Reinhold, C. 1994. Heavy metal-induced cytotoxicity to cultured human epidermal keratinocytes and effects of antioxidants. Toxicol. Lett. 71:105-109.
17. Lau, S., and Sakar, B. 1979. Inorganic mercury(II) binding components in normal human blood serum. J. Toxicol. Environ. Health 5:907-916.
18. Lovstad, R. A. 1984. Ascorbate (vitamin C) and dehydroascorbate stimulation of copper induced hemolysis. Int. J. Biochem. 2:155-159.
19. Lupo, S., Hewitt, W. R., and Rush, G. F. 1986. Cadmium toxicity in the isolated perfused rat liver. Toxicol. Lett. 34:5-11.
20. Müller, L. 1986. Consequences of cadmium toxicity in rat hepatocytes: mitochondrial dysfunction and lipid peroxidation. Toxicology 40:285-295.
21. Müller-Höcker, J., Meyer, V., Wiebecke, B., Hübner, G., and Eife, R. 1988. Copper storage disease of the liver and chronic dietary copper intoxication in two further german infants mimicking Indian Childhood cirrhosis. Pathol. Res. Pract. 183:39-45.
22. Nieminen, A. L., Gores, G. J., Dawson, T. L., Herman, B., and Lemasters, J. J. 1990. Toxic injury from mercuric chloride in rat hepatocytes. J. Biol. Chem. 265:2399-2408.
23. Norseth, T. 1968. The intracellular distribution of mercury in rat liver after a single injection of mercuric chloride. Biochem. Pharmacol. 17:581-593.
24. Ochi, T., Takahashi, K., and Ohsawa, M. 1987. Indirect evidence for the induction of a prooxidant state by cadmium chloride in cultured mammalian cells and a possible mechanism for the induction. Mutat. Res. 180:257-266.
25. Romero, F. J., Soboll, S., and Sies, J. 1984. Mitochondrial and cytosolic glutathione after depletion by phorone in isolated hepatocytes. Experientia 40:365-367.
26. Sáez, G. T., Valls, V., Muniz, P., Perez-Broseta, C., Oliva, M. R., Bannister, J. V., and Bannister, W. H. 1993. The role of glutathione in protection against DNA damage induced by rifamycin and copper(II) ions. Free Radical Res. Commun. 19:81-92.
27. Schilsky, M. N., Blank, R. R., Czaja, M. J., Zern, M. A., Scheinberg, J. H., Stockert, R. J., and Sternlieb, I. 1989. Hepatocellular copper toxicity and its attenuation by zinc. J. Clin. Invest. 84:1562-1568.
28. Schwohl, T., Schroeder, B., Müller-Esch, G., and Djonlagic, H. 1988. Zur Quecksilberelimination mittels Hämofiltration und Hämoperfusion bei akuter Sublimatintoxikation. Intensivmedizin 25:198-201.
29. Siegers, C.-P., Sharma, S. C., and Younes, M. 1986. Hepatotoxicity of metals in glutathione-depleted mice. Toxicol. Lett. 34:185-191.
30. Sokol, R. J., Devereaux, M. W., Traber, M. G., and Shikes, R. H. 1989. Copper toxicity and lipid peroxidation in isolated rat hepatocytes: Effect of vitamin E. Pediat. Res. 25:55-62.
31. Sokol, R. J., Devereaux, M., Mierau, G. W., Hambidge, K. M., and Shikes, R. H. 1990. Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload. Gastroenterology 99:1061-1071.
32. Sokol, R. J., Devereaux, M. W., O'Brien, K., Khandwala, R. A., and Loehr, J. P. 1993. Abnormal hepatic mitochondrial respiration and cytochrome C oxidase activity in rats with long-term copper overload. Gastroenterology 105:178-187.
33. Southard, J., Nitisewojo, P., and Green, D. E. 1974. Mercurial toxicity and the pertubation of the mitochondrial control system. Physiol. Adapt. Environ. 33:2147-2153.
34. Stacey, N. H., and Kappus, H. 1982. Cellular toxicity and lipid peroxidation in response to mercury. Toxicol. Appl. Pharmacol. 63:29-35.
35. Stacey, N. H., and Klaassen, C. D. 1981. Comparison of the effects of metals on cellular injury and lipid peroxidation in isolated rat hepatocytes. J. Toxicol. Environ. Health 7:139-147.
36. Stacey, N. H., Cantilena, L. R., and Klaassen, C. D. 1980. Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes. Toxicol. Appl. Pharmacol. 53:470-480.
37. Sternlieb, J. 1980. Copper and liver. Gastroenterology 78:1615-1628.
38. Theocharis, S., Margeli, A., Fasitsas, C., Loizidou, M., and Deliconstantinos, G. 1991. Acute exposure to cadmium causes time-dependent liver injury in rats. Biochem. Physiol. 99c:127-130.
39. Thurman, R. G., and Reinke, L. A. 1979. The isolated perfused liver: a model to define biochemical mechanisms of chemical toxicity. In Reviews in biochemical toxicology, vol. 1, eds. E. Hodgson, J. R. Bend, and R. M. Philpot, pp. 249-285. New York: Elsevier.
40. Vallee, B. L., and Ulmer, D. D. 1972. Biochemical effects of mercury, cadmium and lead. Annu. Rev. Biochem. 41:91.