In vitro and in vivo characterization of a murine cytomegalovirus with a transposon insertional mutation at open reading frame M43

Journal of Virology

Volumn 74, Issue 20, 2000, Pages 9488-9497

  Xiao, J ^a   Tong, T ^a   Zhan, X ^a   Haghjoo, E ^a   Liu, F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; GENE INSERTION; GENE MUTATION; MOUSE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; SALIVARY GLAND; TRANSPOSON; VIROGENESIS; VIRUS GENE; VIRUS MUTANT; VIRUS REPLICATION; VIRUS SHEDDING; VIRUS TRANSMISSION; VIRUS VIRULENCE;

3T3 CELLS; ANIMAL; BLOTTING, SOUTHERN; DNA TRANSPOSABLE ELEMENTS; GENOME, VIRAL; MALE; MICE; MICE, INBRED BALB C; MICE, SCID; MUROMEGALOVIRUS; OPEN READING FRAMES; RNA, MESSENGER; SALIVARY GLANDS; SUPPORT, NON-U.S. GOV'T; VIRULENCE;

EID: 0033797761     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.20.9488-9497.2000     Document Type: Article

References (50)

1. Characterization of a strain of murine cytomegalovirus which fails to grow in the salivary glands of mice
2. Cytomegalovirus
3. Rapid identification of essential and nonessential herpesvirus genes by direct transposon mutagenesis
4. Murine cytomegalovirus IE2, an activator of gene expression, is dispensable for growth and latency in mice
5. Murine cytomegalovirus with a deletion of genes spanning HindIII-J and -I displays altered cell and tissue tropism
6. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169
7. Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture
8. Generation of varicella-zoster virus (VZV) and viral mutants from cosmid DNAs: VZV thymidylate synthetase is not essential for replication in vitro
9. A cosmid-based system for constructing mutants of herpes simplex virus type 1
10. Identification and characterization of a murine cytomegalovirus gene with homology to the UL25 open reading frame of human cytomegalovirus
11. The published DNA sequence of human cytomegalovirus strain AD169 lacks 929 base pairs affecting genes UL42 and UL43
12. Propagation and recovery of intact, infectious Epstein-Burr virus from prokaryotic to human cells
13. The outcome of congenital cytomegalovirus infection in relation to maternal antibody status
14. Selectable insertion and deletion mutagenesis of the human cytomegalovirus genome using the Escherichia coli guanosine phosphoribosyl transferase (gpt) gene
15. Effect of Nu/Nu gene on genetically determined resistance to murine cytomegalovirus
16. Replication of murine cytomegalovirus in differentiated macrophages as a determinant of viral pathogenesis
17. The murine cytomegalovirus as a model for the study of viral pathogenesis and persistent infections
18. Application of the mini-Mu-phage for target-sequence-specific insertional mutagenesis of the herpes simplex virus genome
19. Latent infection and the elusive cytomegalovirus
20. Defined large-scale alterations of the human cytomegalovirus genome constructed by cotransfection of overlapping cosmids
21. Structure and function of the murine cytomegalovirus sgg1 gene: A determinant of viral growth in salivary gland acinar cells
22. The herpes simplex virus 1 gene encoding a protease also contains within its coding domain the gene encoding the more abundant substrate
23. Insectional mutagenesis of the routine cytomegalovirus genome: One prominent alpha gene (ie2) is dispensable for growth
24. Cytomegalovirus determinant of replication in salivary glands
25. Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome
26. Cytomegaloviruses and their replication
27. A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulation
28. Molecular engineering of the herpes simplex virus genome: Insertion of a second L-S junction into the genome causes additional genome inversions
29. Reassessing the organization of the UL42-UL43 region of the human cytomegalovirus strain AD169 genome
30. Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase
31. The efficacy of biological response modifiers against murine cytomegalovirus infection in normal and immunodeficient mice
32. Latency, without persistence, of murine cytomegalovirus in the spleen and kidney
33. A generalized technique for deletion of specific genes in large genomes: Alpha gene 22 of herpes simplex virus I is not essential for growth
34. Analysis of the complete DNA sequence of routine cytomegalovirus
35. Experimental routine cytomegalovirus infection in severe combined immunodeficient mice
36. Genetic engineering of novel genomes of large DNA viruses
37. Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: Rescue of replication-competent virus progeny and packaging of amplicon vectors
38. Trends in infectious diseases and cancers among persons dying of HIV infection in the United States from 1987 to 1992
39. Effect of the human immunodeficiency virus epidemic on mortality from opportunistic infections in the United States in 1993
40. Construction and transposon mutagenesis in Escherichia coli of a full-length infectious clone of pseudorabies virus, an alphaherpesvirus
41. A self-recombining bacterial artificial chromosome and its application for analysis of herpesvirus pathogenesis
42. An enhanced packaging system for helper-dependent herpes simplex virus vectors
43. Epstein-Barr virus recombinants from overlapping cosmid fragments
44. Regeneration of herpesviruses from molecularly cloned subgenomic fragments
45. Genes in the HindIII J fragment of the routine cytomegalovirus genome are dispensable for growth in cultured cells: Insertion mutagenesis with a lacZ/gpt cassette
46. Systematic excision of vector sequences from the BAC-cloned herpesvirus genome during virus reconstitution
47. Rapid identification of nonessential genes of herpes simplex virus type 1 by Tn5 mutagenesis
48. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
49. Mutagenesis of murine cytomegalovirus using a Tn3-based transposon
50. Construction and characterization of murine cytomegaloviruses that contain a transposon insertion at open reading frames m09 and M83