Expression of interleukin-9 leads to Th2 cytokine-dominated responses and fatal enteropathy in mice with chronic Schistosoma mansoni infections

Infection and Immunity

Volumn 68, Issue 10, 2000, Pages 6005-6011

  Fallon, P G ^a   Smith, P ^a   Richardson, E J ^a   Jones, F J ^a   Faulkner, H C ^a   Van Snick, J ^a   Renauld, J C ^a   Grencis, R K ^a   Dunne, D W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; MUCIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENTEROPATHY; EOSINOPHILIA; FATALITY; GOBLET CELL; HYPERPLASIA; ILEUM; MASTOCYTOSIS; MESENTERY LYMPH NODE; MOUSE; MUSCLE HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; TH2 CELL; TRANSGENIC MOUSE;

EID: 0033797392     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.10.6005-6011.2000     Document Type: Article

References (38)

1. Lung eosinophilia is dependent on IL-5 and the adhesion molecules CD18 and VLA-4, in a guinea-pig model
2. Schistosoma mansoni infections in T-cell deprived mice, and the ameliorating effect of administering homologous chronic infection serum
3. Pathology and pathophysiology of the small intestine in murine schistosomiasis mansoni, including a review of the literature
4. IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice
5. Immunopathology of schistosomiasis: A cautionary tale of mice and men
6. Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection
7. Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent
8. Type 1 and type 2 cytokine-producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection
9. Acute schistosomiasis mansoni in the baboon Papio anubis gives rise to goblet-cell hyperplasia and villus atrophy that are modulated by an irradiated cercarial vaccine
10. Interleukin-9 is involved in host protective immunity to intestinal nematode infection
11. Interleukin-9 enhances resistance to the intestinal nematode Trichuris muris
12. Development of eosinophil peroxidase activity and concomitant alteration of the antioxidant defenses in the liver of mice infected with Schistosoma mansoni
13. Intraepithelial infiltration by mast cells with both connective tissue-type and mucosal-type characteristics in gut, trachea, and kidneys of IL-9 transgenic mice
14. Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni
15. IL-10 and the dangers of immune polarization: Excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis
16. Distribution of intestinal mast cell proteinase in blood and tissues of normal and Trichinella-infected mice
17. A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells
18. Schistosoma mansoni infection in mice augments the capacity for interleukin 3 (IL-3) and IL-9 production and concurrently enlarges progenitor pools for mast cells and granulocytes-macrophages
19. Eosinophils favor the passage of eggs to the intestinal lumen in schistosomiasis
20. Experimental Schistosoma bovis infection in goats: The inflammatory response in the small intestine and liver in various phases of infection and reinfection
21. Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells
22. Interleukin-9 upregulates mucus expression in the airways
23. Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice
24. Hepatic recruitment of mast cells occurs in rats but not mice infected with Schistosoma mansoni
25. Eosinophils and primary biliary cirrhosis - Stoking the fire?
26. Biochemical and immunological characterization of multiple glycoforms of mouse mast cell protease 1: Comparison with an isolated murine serosal mast cell protease (MMCP-4)
27. Trefoil peptide expression and secretion is regulated by neuropeptides and acetylcholine
28. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth
29. Interleukin-9 and its receptor: Involvement in mast cell differentiation and T cell oncogenesis
30. Thymic lymphomas in interleukin 9 transgenic mice
31. Interleukin-9 is a major anti-apoptotic factor for thymic lymphomas
32. Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice
33. IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis
34. The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms
35. Detection of eosinophils using an eosinophil peroxidase assay.Its use as an assay for eosinophil differentiation factors
36. Chemokine-induced eosinophil recruitment. Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin
37. Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness
38. Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population