Effect of radionuclide linker structure on DNA cleavage by 125I-labeled oligonucleotides

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 6, 1997, Pages 549-557

  Karamychev, V N ^a,b   Panyutin, I G ^a   Reed, M W ^c   Neumann, R D ^a,d  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^c Nanogen Inc USA   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; IODINE 125; OLIGODEOXYRIBONUCLEOTIDE; PURINE; PYRIMIDINE; RADIOISOTOPE;

ARTICLE; DNA CLEAVAGE; DNA STRAND BREAKAGE; IODINATION; PRIORITY JOURNAL;

EID: 0031458117     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.549     Document Type: Article

References (14)

1. COONEY, M., CHERNUSZEWICZ, G., POSTEL, E.H., FLINT, S.J., and HOGAN, M.E. (1988). Site-specific oligonucleotide binding represses transcription of the human c-myc gene in vitro. Science 241, 455-459.
2. DESOMBRE, E.R., SHAFII, B., HANSON, R.N., KUIVANEN, P.C., and HUGHES, A. (1992), Estrogen receptor-directed radiotoxicity with Auger electrons: Specificity and mean lethal dose. Cancer Res. 52, 5752-5758.
3. FRANK-KAMENETSKII, M.P., and MIRKIN, S.M. (1995). Triplex DNA structures. Annu. Rev. Biochem. 64, 64-95.
4. GAMPER, H.B., REED, M.W., COX, T., VIROSCO, J.S., ADAMS, A.D., GALL, A.A., SCHOLLER, J.K., and MEYER, R.B. (1993). Facile preparation of nuclease resistant 3′-modified oligodeoxynucleotides. Nucleic Acids Res. 21, 145-148.
5. 125I]iodo-2′-deoxyuridine. Radiat. Res. 118, 532-544.
6. MARTIN, R.F., and HASELTINE, W.A. (1981). Range of radiochemical damage to DNA with decay of iodine-125. Science 213, 896-898.
7. MAXAM, A.M., and GILBERT, W. (1980). Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65, 499-525.
8. ORSON, F.M., McSHAN, W.M., and KINSEY, B.M. (1996). Sequence-specific binding and cleavage of duplex DNA by a radioiodinated, intercalator-linked, triplex-forming oligonucleotide. Nucl. Med. Biol. 23, 519-524.
9. 125I-labeled oligonucleotides. Nucleic Acids Res. 22, 4979-4982.
10. 125I incorporated into a triplex-forming oligonucleotide correlates with geometry of the triplex. Nucleic Acids Res. 25, 883-887.
11. 125I-labeled oligonucleotides from tributylstannylbenzamide conjugates. Bioconjugate Chem. 8, 248-243.
12. STEIN, C.A., and CHENG, Y.C. (1993). Antisense oligonucleotides as therapeutic agents: Is the bullet really magical? Science 261, 1004-1012.
13. TABONE, J.C., STAMM, M.R., GAMPER, H.B., and MEYER, R.B. (1994). Factors influencing the extent and regiospecificity of cross-link formation between single stranded DNA and reactive complementary oligodeoxynucleotides. Biochemistry 33, 375-379.
14. WILBUR, D.S., HADLEY, S.W., HYLARIDES, M.D., ABRAMS, P.O., BEAUMIER, P.L., MORGAN, A.C., RENO, J., and FRITZBERG, A.R. (1989). Development of a stable radioiodinating reagent to label monoclonal antibodies for radiotherapy of cancer. J. Nucl. Med. 30, 216-226.