A novel hematopoietic multilineage clone, Myl-D-7, is stromal cell-dependent and supported by an alternative mechanism(s) independent of stem cell factor/c-kit interaction

Blood

Volumn 87, Issue 8, 1996, Pages 3218-3228

  Itoh, Katsuhiko ^b   Friel, Jutta ^b   Kluge, Norbert ^b   Kina, Tatsuo ^b   Kondo Takaori, Akifumi ^b   Kawamata, Shin ^b   Uchiyama, Takashi ^b   Ostertag, Wolfram ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; STEM CELL FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CLONE; HEMATOPOIESIS; HEMATOPOIETIC CELL; IMMUNOPHENOTYPING; MOUSE; NONHUMAN; ONCOGENE C KIT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; STROMA CELL;

ANIMALS; APOPTOSIS; BIOLOGICAL FACTORS; BIOLOGICAL MARKERS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CLONE CELLS; COCULTURE TECHNIQUES; COLONY-FORMING UNITS ASSAY; CONNECTIVE TISSUE; CONNECTIVE TISSUE CELLS; CULTURE MEDIA, CONDITIONED; DEFECTIVE VIRUSES; FEMALE; FRIEND MURINE LEUKEMIA VIRUS; GENETIC VECTORS; HELPER VIRUSES; HEMATOPOIETIC CELL GROWTH FACTORS; HEMATOPOIETIC STEM CELLS; MICE; MICE, INBRED DBA; MICE, MUTANT STRAINS; MICE, SCID; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTORS, GROWTH FACTOR; RECOMBINANT PROTEINS; SARCOMA VIRUSES, MURINE; SPLEEN; SPLEEN FOCUS-FORMING VIRUSES; STEM CELL FACTOR;

EID: 0029981527     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.8.3218.bloodjournal8783218     Document Type: Article

References (54)

1. Abramson S, Miller RG, Phillips RA: The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems. J Exp Med 145:1567, 1977
2. v mice. Cell 42:71, 1985
3. Till JE, McCulloch EA: A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14 213, 1961
4. Stephen JS, Lansdrop PM, Humphries RK, Eaves AC, Eaves CJ: Isolation in a single step of a high enriched murine hematopoietic stem cell population with competitive long-term repopulating ability. Blood 74:930, 1989
5. Spangrude GJ, Heimfeld S, Weissman IL: Purification and characterization of mouse hematopoietic stem cells. Science 241:58, 1988
6. Dorshkind K: Regulation of hemopoiesis by bone marrow stromal cells and their products. Annu Rev Immunol 8:111, 1990
7. Mori KJ, Fujitake H, Okubo H, Dexter TM, Ito Y: Quantitative development of adherent cell colonies in bone marrow cell culture in vitro. Exp Hematol 7:171 1979
8. Dexter TM, Allen TD, Lajtha LG: Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 91:335, 1977
9. Kodama H, Sudo H, Koyama H, Kasai S, Yamamoto S: In vitro hemopoiesis within a microenvironment created by MC3T3-G2/PA6 preadipocytes. J Cell Physiol 118:233, 1984
10. Itoh K, Tezuka H, Sakoda H, Konno M, Nagata K, Uchiyama T, Uchino H, Mori KJ: Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrow. Exp Hematol 17:145, 1989
11. Rusell ES: Hereditary anemia of the mouse: A review for geneticists. Adv Genet 20:357, 1979
12. Chabot B, Stephenson DA, Chapman VM. Besmer P, Bernstein A: The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335:88, 1988
13. Geissler EN, Ryan MA, Housman DE: The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55:185, 1988
14. Zsebo KM, William DA, Geissler EN, Broudy VC, Martin FH, Atkins HL, Hsu R-Y, Birkett NC, Okino KH, Murdock DC, Jacobsen FW, Langley KE, Smith KA, Takeishi T, Cattanach BM, Galli SJ, Suggs SV. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 63:213, 1990
15. Huang E, Nocka N, Beier DR, Chu T-Y, Buck J, Lahm H-W, Wellner D, Leder P, Besmer P: The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell 63:225, 1990
16. Okada S, Nakauchi H, Nagayoshi K, Nishikawa S, Nishikawa S-I, Miura Y, Suda T: Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule. Blood 78:1706, 1991
17. Nishikawa S, Kusakabe M, Yoshinaga K, Ogawa M, Hayashi S-I, Kunisada T, Era T, Sakakura T, Nishikawa S-I: In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: Two distinct waves of c-kit-dependency during melanocyte development. EMBO J 10:2111, 1991
18. Ogawa M, Matsuzaki S, Nishikawa S, Hayashi S-I, Kunisada T, Suda T, Kina T, Nakauchi H, Nishikawa S-I: Expression and function of c-kit in hemopoietic progenitor cells. J Exp Med 174:63, 1990
19. Dexter TM, Moore MAS: In vitro duplication and cure of haematopoietic defects in genetically anemic mice. Nature 269:412, 1977
20. Ikuta K, Weissman IL: Evidence that hematopoietic stem cell express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci USA 89:1502, 1992
21. Kodama H, Nose M, Yamaguchi Y, Tsunoda J-I, Suda T, Nishikawa S, Nishikawa S-I: In vitro proliferation of primitive hemopoietic stem cells supported by stromal cells: Evidence for the presence of a mechanism(s) other than that involving c-kit receptor and its ligand. J Exp Med 176:351, 1992
22. Sutherland HJ, Hogge DE, Cook D, Eaves CJ: Alternative mechanisms with and without Steel factor support primitive human hematopoiesis. Blood 81:1465, 1993
23. Caruana J, Ashman LK, Fujita J, Gonda TJ: Response of the murine myeloid cell line FDC-P1 to soluble and membrane-bound forms of steel factor (SCF). Exp Hematol 21:761, 1993
24. Ahlers N, Hunt N, Just U, Laker C, Ostertag W, Nowock J: Selectable retrovirus vectors encoding Friend virus gp55 or erythropoietin induce polycythemia with different phenotypic expression and disease progression. J Virol 68:7235, 1994
25. Stocking C, Kollek R, Bergholz U, Ostertag W: Long terminal repeat sequences impart hematopoietic transformation property to the myeloproliferative sarcoma virus. Proc Natl Acad Sci USA 82:5746, 1985
26. Ikuta K, Kina T, MacNeil I, Uchida N, Peault B, Chen Y-H, Weissman IL: A development switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell 62:863, 1990
27. Veis DJ, Sentrnan CL, Bach BA, Korsmeyer SJ: Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes J Immunol 151:2546, 1993
28. Sutherland HJ, Lansdorp PM, Henkelman DH, Eaves AC, Eaves CJ: Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc Natl Acad Sci USA 87:3584, 1990
29. Heberlein C, Fischer K-D, Stoffel M, Nowock A, Ford A, Tessmer U, Stocking C: The gene for erythropoietin receptor is expressed in multipotential hematopoietic and embryonal stem cells: Evidence for differentiation stage-specific regulation. Mol Cell Biol 12:1815, 1992
30. Just U, Friel J, Heberlein C, Baccarini M, Tamura T, Tessmer U, Klingler K, Ostertag W: Upregulation of lineage specific receptors and ligands in myeloid stem cells is part of an endogenous program of differentiation. Growth Factors 9:291, 1993
31. McClanahan T, Dalrymple S, Barkett M, Lee F: Hematopoietic growth factor receptor genes as markers of lineage commitment during in vitro development of hemopoietic cells. Blood 81:2903, 1993
32. Keller G, Kennedy M, Papayannopoulou T, Wiles MV: Hemopoietic commitment during embryonic stem cell differentiation in culture. Mol Cell Biol 13:473, 1993
33. Georgopoulos K, Moore DD, Derfler B: Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science 258:808, 1992
34. Georgopoulos K, Bigby M, Wang J-H, Molnar A, Wu P, Winandy S, Sharpe A: The ikaros gene is required for the development of all lymphoid lineages. Cell 79:143, 1994
35. Hockenberry D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334, 1990
36. d mutant. Cell 64:1025, 1991
37. Kobari L, Dubart A, Le Pesteur F, Vainchenker W, Sainteny F: Hematopoietic-promoting activity of the murine stromal cell line MS-5 is not related to the expression of the major hematopoietic cytokines. J Cell Physiol 163:295, 1995
38. Lyman SD, James L, Bos TV, Vries PD, Brasel K, Gliniak B, Hollingsworth LT, Picha KS, McKenna HJ, Splett RR, Fletcher FA, Maraskovsky E, Farrah T, Foxworthe D, Williams DE, Beckmann MP: Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells. Cell 75:1157, 1993
39. Takashita E, Sugimoto K, Adachi Y, Mori KJ: Induction of bcl-2 gene expression by intercellular information from hemopoietic supportive stromal cells to DA-1 cells. J Cell Physiol 161:367, 1994
40. Itoh K, Sasaki R, Ono K, Tezuka H, Sakoda H, Sawada H, Hitomi K, Nakane H, Uchiyama T, Uchino H, Mori KJ: Stromal cell-dependent growth of leukemic cells from murine erythroblastic leukemia. Jpn J Cancer Res 79:931, 1988
41. Nibbs RJB, Itoh K, Ostertag W, Harrison PR: Differentiation arrest and stromal cell-dependent growth of murine erythroleukemia cells are associated with elevated expression of ets-related genes, but not mutation of p53. Mol Cell Biol 13:5582, 1993
42. Veis DJ, Sorenson CM, Shutter SJ, Korsmeyer SJ: Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys and hypopigmented hair. Cell 75:229, 1993
43. Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST: The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Mol Cell Biol 14:7111, 1994
44. Molnar A, Georgopoulos K: The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol Cell Biol 14:8292, 1994
45. Gough NM, Metcalf D, Gough J, Grail D, Dunn AR: Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor. EMBO J 4:645, 1985
46. Chiu CP, Moulds C, Coffman RL, Rennick D, Lee F: Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. Proc Natl Acad Sci USA 85:7099, 1988
47. Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D, Gillis S, Cosman D, Goodwin RG: Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 333:571, 1988
48. Anderson DM, Lyman SD, Baird A, Wignall JM, Eisenman J, Rauch C, March CJ, Boswell HS, Gimpel SD, Cosman D, Williams DE: Molecular cloning of mast cell growth factor, that is active in both membrane bound and soluble forms. Cell 63:235, 1990
49. Shimizu A, Kondo S, Takeda S-I, Yodoi J, Ishida N, Sabe H, Osawa H, Diamantstein T, Nikaido T, Honjo T: Nucleotide sequence of mouse EL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence. Nucleic Acids Res 13:1505, 1985
50. Kono T, Doi T, Yamada G, Hatakeyama M, Minamoto S, Tsudo M, Miyasaka M, Miyata T, Taniguchi T: Murine interleukin 2 receptor β chain: Dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion. Proc Natl Acad Sci USA 87:1806, 1990
51. Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosma D, Dower SK, March CJ, Namen AE, Park LS: Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily. Cell 60:941, 1990
52. Gorman DM, Itoh N, Kitamura T, Schreurs J, Yonehara S, Yahara I, Arai K-I, Miyajima A: Cloning and expression of a gene encoding an interleukin 3-like protein: Identification of another member of the cytokine receptor gene family. Proc Natl Acad Sci USA 87:5459, 1990
53. Kumaki S, Kondo M, Takeshita T, Asao H, Nakamura M, Sugamura K: Cloning of the mouse interleukin 2 receptor γ chain: Demonstration of functional differences between the mouse and human receptors. Biochem Biophys Res Commun 193:356, 1993
54. Saito M, Yoshida K, Hibi M, Taga T, Kishimoto T: Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J Immunol 148:4066, 1992