Reversible dimerization of 20 kilodalton human growth hormone-(hgH)

Growth Hormone and IGF Research

Volumn 10, Issue 4, 2000, Pages 207-214

  Nagatomi, Y ^a   Ikeda, M ^a   Uchida, H ^a   Wada, M ^a   Kobayashi, H ^a   Hashimoto, Y ^b   Mabuchi, K ^b   Hayakawa, M ^b   Kusuhara, N ^a   Honjo, M ^a  

^a MITSUI CHEMICALS INC   (Japan)

^b Mitsui Pharmaceut Inc   (Japan)

Author keywords

20 K hGH; Cell proliferation activity; Dimerization; Growth promoting activity; Pharmacokinetics

Indexed keywords

GROWTH HORMONE DERIVATIVE; HUMAN GROWTH HORMONE;

ANIMAL CELL; ARTICLE; DIMERIZATION; DISSOCIATION; DRUG POTENCY; HORMONE ACTION; HORMONE BLOOD LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033792439     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1054/ghir.2000.0156     Document Type: Article

References (20)

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15. Biosynthetic 20-kilodalton methyonyl-human growth hormone has diabetogenic and insulin-like activities
16. The 20-kilodalton (kDa) human growth hormone (hGH) differs from the 22-kDa hGH in the complex formulation with cell surface hGH receptor and hGH-binding protein circulating in human plasma
17. Secretion of authentic 20-kDa human growth hormone (20 K hGH) in Esherichia coli and properties of the purified product
18. Construction of a specific and sensitive sandwich enzymed immunoassay for 20 kDa human growth hormone
19. Biological characterization of purified native 20-kDa human growth hormone
20. The metabolic clearance, distribution, and degradation of dimeric and monomeric growth hormone (GH): Implications for the pattern of circulating GH forms