Randomised comparison of partial liquid ventilation, nebulised perfluorocarbon, porcine surfactant, artificial surfactant, and combined treatments on oxygenation, lung mechanics, and survival in rabbits after saline lung lavage

Intensive Care Medicine

Volumn 26, Issue 10, 2000, Pages 1523-1530

  Kelly, K P ^a   Stenson, B J ^b   Drummond, G B ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Acute respiratory distress syndrome (ARDS); Nebulisation; Partial liquid ventilation; Rabbit; Surfactant

Indexed keywords

ARTIFICIAL LUNG SURFACTANT; FLUOROCARBON; LUNG SURFACTANT EXTRACT; PF 5080; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; FEMALE; GAS EXCHANGE; LUNG INJURY; LUNG LAVAGE; LUNG MECHANICS; NEBULIZATION; NONHUMAN; OXYGENATION; PARTIAL LIQUID VENTILATION; PROSPECTIVE STUDY; RABBIT; SURVIVAL;

ADMINISTRATION, INHALATION; ANIMAL; BLOOD GAS ANALYSIS; COMBINED MODALITY THERAPY; COMPARATIVE STUDY; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FEMALE; FLUOROCARBONS; IRRIGATION; LIQUID VENTILATION; LUNG COMPLIANCE; PHOSPHOLIPIDS; PROSPECTIVE STUDIES; PULMONARY GAS EXCHANGE; PULMONARY SURFACTANTS; RABBITS; RANDOM ALLOCATION; RESPIRATORY DISTRESS SYNDROME, ADULT; SODIUM CHLORIDE; SUPPORT, NON-U.S. GOV'T; SURVIVAL ANALYSIS; SWINE; TREATMENT OUTCOME;

EID: 0033791633     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001340000646     Document Type: Article

References (40)

1. Surfactant and the adult respiratory distress syndrome
2. In vivo lung lavage as an experimental model of the respiratory distress syndrome
3. Modes of artificial ventilation in severe respiratory distress syndrome. Lung function and morphology in rabbits after wash-out of alveolar surfactant
4. Perfluorocarbon-associated gas exchange
5. Intratracheal perfluorocarbon administration combined with mechanical ventilation in experimental respiratory distress syndrome: Dose-dependent improvement of gas exchange
6. Exogenous surfactant and partial liquid ventilation: Physiologic and pathologic effects
7. Animal models and clinical pilot studies of surfactant replacement in adult respiratory distress syndrome
8. Exogenous surfactant therapy increases static lung compliance and cannot be assessed by measurements of dynamic compliance alone
9. Importance of hydrophobic apoproteins as constituents of clinical exogenous surfactants
10. Effects of surfactant proteins SP-B and SP-C on dynamic and static mechanics of immature lungs
11. Role of pulmonary surfactant in the development and treatment of adult respiratory distress syndrome
12. Surfactant inhibition by plasma proteins: Differential sensitivity of various surfactant preparations
13. Partial liquid ventilation enhances surfactant phospholipid production
14. Effects of partial liquid ventilation with perfluorodecalin in the juvenile rabbit lung after saline injury
15. Decrease in lung volume depends on end-expiratory pressure in a rabbit model of airway lavage
16. Prolonged studies of perfluorocarbon-associated gas exchange and of the resumption of conventional mechanical ventilation
17. Randomized trial of artificial surfactant (ALEC) given at birth to babies from 23 to 34 weeks gestation
18. Structural and functional characterisation of porcine surfactant isolated by liquid-gel chromatography
19. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome
20. Concealed air leak associated with large tidal volumes in partial liquid ventilation
21. Vaporized perfluorocarbon improves oxygenation and pulmonary function in an ovine model of acute respiratory distress syndrome
22. Differential sensitivity to fibrinogen inhibition of SP-C- vs SP-B-based surfactants
23. Protein composition and surface activity of commercial surfacrant preparations
24. A controlled clinical comparison of four different surfactant preparations in surfactant-deficient preterm lambs
25. Randomised clinical trial of two treatment regimens of natural surfactant preparations in neonatal respiratory distress syndrome
26. Overview of clinical trials comparing natural and synthetic surfactants
27. Ten centre trial of artificial surfactant (artificial lung expanding compound) in very premature babies. Ten Centre Study Group
28. Partial liquid ventilation in premature lambs with respiratory distress syndrome: Efficacy and compatibility with exogenous surfactant
29. Compliance of the respiratory system in newborn infants pre- and post-surfactant replacement therapy
30. Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome. Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group
31. Bovine surfactant therapy for patients with acute respiratory distress syndrome
32. Liquid ventilation in adults, children, and full-term neonates
33. Partial liquid ventilation in adult patients with ARDS: A multicenter phase I-II trial. Adult PLV Study Group
34. Initial experience with partial liquid ventilation in pediatric patients with the acute respiratory distress syndrome
35. Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome
36. Comparison of exogenous surfactant therapy, mechanical ventilation with high end-expiratory pressure and partial liquid ventilation in a model of acute lung injury
37. Partial liquid ventilation with surfactant: Effects on gas exchange and lung pathology in surfactant-depleted piglets
38. High-frequency oscillatory ventilation, partial liquid ventilation, or conventional mechanical Ventilation in newborn piglets with saline lavage-induced acute lung injury. A comparison of gas-exchange efficacy and lung histomorphology
39. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: A randomized controlled trial
40. Respiratory physiology and acute lung injury: The miracle of Lazarus