Increase of the isoprostane 8-isoprostaglandin F2(α) in maternal and fetal blood of rats with streptozotocin-induced diabetes: Evidence of lipid peroxidation

American Journal of Obstetrics and Gynecology

Volumn 183, Issue 4, 2000, Pages 1035-1040

  Gerber, Robert T ^a,b,c,d   Holemans, Kathleen ^a,b,c,d   O'Brien Coker, Ivan ^a,b,c,d   Mallet, Anthony I ^a,b,c,d   Van Bree, Rita ^a,b,c,d   Van Assche, F André ^a,b,c,d   Poston, Lucilla ^a,b,c,d  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c UNIVERSITY OF GREENWICH   (United Kingdom)

^d DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY   (United Kingdom)

Author keywords

Diabetes; Isoprostanes; Oxidative stress; Pregnancy; Rat

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; FREE RADICAL; ISOPROSTANE; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; BLOOD SAMPLING; CONFERENCE PAPER; FETUS; FETUS BLOOD; GAS CHROMATOGRAPHY; LIPID PEROXIDATION; MASS SPECTROMETRY; MATERNAL BLOOD; MORPHOGENESIS; NONHUMAN; OXIDATIVE STRESS; PREGNANCY COMPLICATION; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

EID: 0033787720     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1067/mob.2000.107115     Document Type: Conference Paper

References (25)

1. Oxidative stress and lipids in diabetes: A role in endothelium vasodilator dysfunction?
2. Diabetes mellitus and free radicals
3. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: A randomized trial
4. Type 1 diabetes mellitus and pregnancy
5. Oxidative DNA damage and embryo development
6. The role of free radicals and membrane lipids in diabetes-induced congenital malformations
7. Protection by free oxygen radical scavenging enzymes against glucose-induced embryonic malformations in vitro
8. The isoprostanes: Current knowledge and directions for future research
9. The generation and action of isoprostanes
10. 2 levels in rat embryos exposed to a diabetic environment
11. Dietary antioxidant supplementation reduces lipid peroxidation but impairs vascular function in small mesenteric arteries of the streptozotocin-diabetic rat
12. 2(α) levels are elevated in individuals with non-insulin dependent diabetes mellitus
13. Significance of glutathione depletion and oxidative stress in early embryogenesis in glucose-induced rat embryo culture
14. Modification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency
15. Association of gestational diabetes with abnormal maternal vascular endothelial function
16. Circulating markers of oxidative stress are raised in normal pregnancy and pre-eclampsia
17. Hyperglycemia-induced embryonic dysmorphogenesis correlates with genomic DNA mutation frequency in vitro and in vivo
18. Impaired glucose tolerance in adolescent offspring of diabetic mothers: Relationship to fetal hyperinsulinism
19. Evidence for an insulin resistance in the adult offspring of pregnant streptozotocindiabetic rats
20. Streptozotocin diabetes in the pregnant rat induces cardiovascular dysfunction in adult offspring
21. Raised saturated fat intake worsens vascular function in virgin and pregnant offspring of streptozotocindiabetic rats
22. Placental lipid and glycogen content in human and experimental diabetes
23. Fetal and placental size and risk of hypertension in adult life
24. 2 receptors
25. 2(α)