Effects of tumour necrosis factor-α and inhibition of protein kinase C on glucose uptake in L6 myoblasts

Clinical Science

Volumn 99, Issue 4, 2000, Pages 303-307

  Patiag, D ^a   Gray, S ^a   Idris, I ^a   Donnelly, R ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Insulin resistance; PKC; TNF

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; GLUCOSE; INSULIN; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CACHEXIA; CONTROLLED STUDY; CYTOKINE RELEASE; DIABETES MELLITUS; ENZYME INHIBITION; GLUCOSE TRANSPORT; INSULIN RESISTANCE; INSULIN SENSITIVITY; MYOBLAST; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; SEPSIS; SKELETAL MUSCLE;

EID: 0033783156     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0990303     Document Type: Article

References (35)

1. Tumour necrosis factor-α: A key component of the obesity-diabetes link
2. Adipose expression of tumour necrosis factor-α: Direct role in obesity-linked insulin resistance
3. Advanced age and insulin resistance: Role of plasma tumour necrosis factor-α
4. Through thick and thin: Wasting, obesity and TNF-α
5. The expression of TNF-α by human muscle
6. Increased adipose tissue expression of tumour necrosis factor-α in human obesity and insulin resistance
7. Tumour necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output
8. Effects of tumour necrosis factor-α (TNF-α) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture
9. TNF-α inhibits signaling from insulin receptor
10. Tumour necrosis factor promotes phosphorylation and binding of insulin receptor substrate-1 to phosphatidylinositol 3-kinase in 3T3-L1 adipocytes
11. Tumour necrosis factor-α-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT-4 expression without a loss of insulin receptor-mediated signal transduction
12. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α and obesity-induced insulin resistance
13. Protein kinase C (PKC) Epsilon enhances the inhibitory effect of TNF-α on insulin signaling in HEK293 cells
14. Effect of tumour necrosis factor-α on insulin signal transduction in rat adipocytes: Relation to PKCβ and ζ translocation
15. Effects of tumour necrosis factor-α on glucose metabolism in cultured human muscle cells from nondiabetic and type 2 diabetic subjects
16. TNF-α stimulates glucose uptake in L6 myoblasts
17. Cytokines modulate glucose transport in skeletal muscle by inducing the expression of inducible nitric oxide synthase
18. Effect of tumour necrosis factor-α on insulin action in cultured rat skeletal muscle cells
19. Short-term exposure to tumour necrosis factor-α does not affect insulin-stimulated glucose uptake in skeletal muscle
20. Effect of tumour necrosis factor-α on basal and insulin-stimulated glucose transport in cultured muscle and fat cells
21. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
22. Developmental regulation of the subcellular distribution and glycosylation of GLUT1 and GLUT4 glucose transporters during myogenesis of L6 muscle cells
23. 2+ transients
24. Tumour necrosis factor-α modulates the expression of its p60 receptor and several cytokines in rat tracheal epithelial cells
25. Evidence for the presence of tumor necrosis factor alpha receptors during ovarian development in the rat
26. Insulin and glucose-dependent regulation of glucose transport system in the rat L6 skeletal muscle cell line
27. Antidiabetic thiazolidinediones block the inhibitory effect of tumour necrosis factor-α on differentiation, insulin-stimulated glucose uptake and gene expression in 3T3-L1 cells
28. Induction of sugar uptake response to insulin by serum depletion in fusing L6 myoblasts
29. Molecular cloning and expression of a receptor for human tumour necrosis factor
30. Arachidonic acid selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumour necrosis factor
31. Differential regulation of the p80 tumour necrosis factor receptor in human obesity and insulin resistance
32. Tumour necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin stimulated tyrosine phosphorylation of IRS-1
33. Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat
34. Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - Effects of feeding
35. Protein kinase C inhibitors block insulin and PMA-stimulated hexose transport in isolated rat adipocytes