A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations

British Journal of Haematology

Volumn 110, Issue 3, 2000, Pages 599-604

  Coulthard, Sally A ^a   Rabello, Celia ^a   Robson, Jill ^a   Howell, Christopher ^a   Minto, Lynne ^a   Middleton, Peter G ^b   Gandhi, Maher K ^b   Jackson, Graham ^b   McLelland, Janet ^b   O'Brien, Hugh ^c   Smith, Stephen ^d   Reid, Michael M ^b   Pearson, Andrew D J ^b   Hall, Andrew G ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b ROYAL VICTORIA INFIRMARY   (United Kingdom)

^c CUMBERLAND INFIRMARY   (United Kingdom)

^d TORBAY HOSPITAL   (United Kingdom)

Author keywords

Leukaemia; Mercaptopurine; Mutation analysis; Pharmacogenetics; Thioguanine

Indexed keywords

AZATHIOPRINE; DNA; MERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE; TIOGUANINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; BONE MARROW CELL; BONE MARROW SUPPRESSION; CHILD; CONTROLLED STUDY; DRUG METABOLISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME DEFECT; ERYTHROCYTE; FEMALE; GENE MUTATION; GENOTYPE; HUMAN; HUMAN CELL; LYMPHOBLAST; MAJOR CLINICAL STUDY; MALE; METHYLATION; MOLECULAR GENETICS; PHENOTYPE; PRIORITY JOURNAL;

6-MERCAPTOPURINE; ADOLESCENT; ADULT; AZATHIOPRINE; BLOOD DONORS; CHILD; CHILD, PRESCHOOL; DNA MUTATIONAL ANALYSIS; FEMALE; GENOTYPE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; MALE; METHYLTRANSFERASES; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; THIOGUANINE;

EID: 0033782140     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02218.x     Document Type: Article

References (23)

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