Positive inotropic effects of imidazoline derivatives are not mediated via imidazoline binding sites but α1-adrenergic receptors

Japanese Journal of Pharmacology

Volumn 84, Issue 1, 2000, Pages 1-6

  Raasch, W ^a   Chun, K R J ^a   Dendorfer, A ^a   Dominiak, P ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Agmatine; Cardiac contractility; Imidazoline binding site; Moxonidine; 1 Adreoceptor

Indexed keywords

AGMATINE; ALPHA 1 ADRENERGIC RECEPTOR; CIRAZOLINE; CLONIDINE; GUANABENZ; IDAZOXAN; IMIDAZOLINE DERIVATIVE; MOXONIDINE; PRAZOSIN;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG BINDING SITE; DRUG COMPETITION; DRUG EFFECT; DRUG SPECIFICITY; HEART LEFT ATRIUM; HEART MUSCLE CONTRACTILITY; INOTROPISM; LIGAND BINDING; MALE; NONHUMAN; RAT;

EID: 0033779883     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.84.1     Document Type: Article

References (35)

1. Lack of cross-desensitization between structurally dissimilar alpha-adrenoceptor agonists
2. Central cardiovascular effects of alpha adrenergic drugs: Differences between catecholamines and imidazolines
3. Clonidine binds to imidazole binding sites as well as alpha 2-adrenoceptors in the ventrolateral medulla
4. Are there multiple imidazoline binding sites?
5. The elusive family of imidazoline binding sites
6. Imidazoline receptors in the nervous system
7. Renal imidazoline preferring sites and solute excretion in the rat
8. An insulin-releasing property of imidazoline derivatives is not limited to compounds that block alpha-adrenoceptors
9. 3H]-idazoxan binding sites in human cardiovascular tissues
10. 1-imidazoline receptors in the rostral ventrolateral medulla
11. Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area
12. Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits
13. Ethanol counteraction of I1-imidazoline but not alpha-2 adrenergic receptor-mediated reduction in vascular resistance in conscious spontaneously hypertensive rats
14. + transport and intracellular pH in renal proximal tubule cells
15. Comparative analysis of effects of imidazoline drugs on isolated rat heart atria
16. 1-imidazoline receptor
17. Agmatine: An endogenous clonidine-displacing substance in the brain
18. Agmatine, the bacterial is widely distributed in mammalian tissues
19. Effects of agmatine on the cardiovascular system of spontaneously hypertensive rats
20. Expression of non-adrenergic imidazoline sites in chromaffin cells and mitochondrial membranes of bovine adrenal medulla
21. Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist
22. Selectivity of some alpha adrenoceptor agonists for peripheral alpha-1 and alpha-2 adrenoceptors in the normotensive rat
23. 2-type receptors: Pharmacological characterization and relationship to monoamine oxidase
24. Characterization of an imidazoline/guanidinium receptive site distinct from the alpha 2-adrenergic receptor
25. Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip
26. Stimulant action of methoxamine in the isolated atria of normal and 6-propyl-2-thiouracil-fed rats
27. On the presence and distribution of alpha-adrenoceptors in the heart of various mammalian species
28. Unique presynaptic alpha 2-receptor selectivity and specificity of the antihypertensive agent moxonidine
29. Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla
30. 3H]-idazoxan to alpha 2-adrenoceptors and non-adrenoceptor, imidazoline binding sites in the central nervous system
31. 1-imidazoline sites in bovine adrenal medullary membranes
32. Identification of an imidazoline-guanidinium receptive site in mitochondria from rabbit cerebral cortex
33. 2-imidazoline binding sites on monoamine oxidases
34. Modulation of MAO activity by imidazoline and guanidine derivatives
35. Monoamine oxidase and semicarbazide-sensitive amine oxidase activities in isolated cardiomyocytes of spontaneously hypertensive rats