Bone morphogenetic protein (BMP): From basic studies to clinical approaches

Folia Pharmacologica Japonica

Volumn 116, Issue 4, 2000, Pages 232-240

  Takahashi, K ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Bone defect; Bone formation; Bone morphogenetic protein; Carrier; Osteoblast

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; DRUG CARRIER; PROTEIN SERINE THREONINE KINASE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; TRANSFORMING GROWTH FACTOR BETA;

BONE; CELL DIFFERENTIATION; GENE; MESENCHYME CELL; NONHUMAN; OSSIFICATION; OSTEOBLAST; REVIEW; SIGNAL TRANSDUCTION;

EID: 0033778811     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: 10.1254/fpj.116.232     Document Type: Review

References (30)

1. Bone: Formation by autoinduction
2. Novel regulators of bone formation: Molecular clones and activities
3. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair
4. Recombinant human bone morphogenetic protein induces bone formation
5. The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2
6. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic diffentiation in vitro
7. The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2
8. Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes
9. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-β gene family
10. The mouse short ear skeletal morphogenesis locus ia associated with defects in a bone morphogenetic member of the TGF-beta superfamily
11. Limb alternations in brachypodism mice due to mutations in a new member of the TGF-β superfamily
12. A human chondrodysplasia due to a mutation in a TGF-β superfamily member
13. Cloning and characterization of a human type II receptor for bone morphogenetic proteins
14. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4
15. Human type II receptor for bone morphogenetic proteins (BMPs): Extension of the two-kinase receptor model to the BMPs
16. Genetic characterization and cloning of mothers against dpp, a gene required for decapenta plegic function in Drosophila melanogaster
17. TGF-signalling from cell membrane to nucleus through SMAD proteins
18. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
19. Smad6 inhibits signalling by the TGF-β superfamily
20. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
21. Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
22. Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
23. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
24. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
25. Bone morphogenetic proteins are required in vivo for the generation of sympathetic neurons
26. Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2
27. Bone morphogenetic protein-2 but not bone morphogenetic protein-4 and -6 stimulates chemotactic migration of human osteoblasts, human marrow osteoblasts, and U2-OS cells
28. Periodontal regeneration by application of rhBMP-2 to holizontal circumferential deffects created by experimental periodontotis in beagle dogs
29. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation