Nitric oxide stimulatory and endothelial protective effects of idoxifene, a selective estrogen receptor modulator, in the splanchnic artery of the ovariectomized rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 295, Issue 2, 2000, Pages 786-792

  Ma, X L ^a   Gao, F ^a   Yao, C L ^a   Chen, J ^a   Lopez, B L ^a   Christopher, T A ^a   Disa, J ^a   Gu, J L ^a   Ohlstein, E H ^a   Yue, T L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; IDOXIFENE; N(G) NITRO DEXTRO ARGININE METHYL ESTER; NITRIC OXIDE; SODIUM NITRATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; DRUG EFFECT; ENDOMETRIUM CANCER; ENDOTHELIUM INJURY; ESTROGEN THERAPY; FEMALE; ISCHEMIA; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTECTION; RAT; REPERFUSION INJURY; SPLANCHNIC BLOOD FLOW; SUPERIOR MESENTERIC ARTERY;

ANIMAL; COMPARATIVE STUDY; ENDOTHELIUM, VASCULAR; ESTRADIOL; FEMALE; IN VITRO; MESENTERIC ARTERY, SUPERIOR; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TAMOXIFEN; TUMOR NECROSIS FACTOR; VASODILATOR AGENTS;

EID: 0033776632     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Endothelial cytosolic proteins bind to the 3' untranslated region of endothelial nitric oxide synthase mRNA: Regulation by tumor necrosis factor alpha
2. Role of the endothelium in the genesis of cardiovascular disease
3. Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactlve nitric oxide by inhibiting superoxide anion production
4. Estrogen and coronary heart disease in women
5. Effects of oestrogens and selective oostrogen receptor modulators on serum lipoproteins and vascular function
6. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen
7. NO from smooth muscle cells decreases NOS expression in endothelial cells: Role of TNF-alpha
8. Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth
9. Raloxifene acutely relaxes rabbit coronary arteries in vitro by an estrogen receptor-dependent and nitric oxide-dependent mechanism
10. Postmenopausal use of estrogen and occlusion of coronary arteries
11. Are women using postmenopausal estrogens? A community survey
12. Endothelial dysfunction in atherosclerosis
13. Estrogen replacement therapy: Indications and complications
14. Potential cellular signaling mechanisms mediating upregulation of endothelial nitric oxide production by estrogen
15. Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor alpha localized in caveolae
16. Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischemia
17. Exogenous NO inhibits basal NO release from vascular endothelium in vitro and in vivo
18. Hypercholesterolemia impairs a detoxification mechanism against peroxynitrite and renders the vascular tissue more susceptible to oxidative injury
19. Gender, estrogen, and NOS: Cautions about generalizations
20. Selective estrogen receptor modulators: A leek ahead
21. Estrogen induces nitric oxide-mediated vasodilation of human mammary arteries in vitro
22. Idoxifene: A novel selective estrogen receptor modulator prevents bone loss and lowers cholesterol levels in ovariectomized rats and decreases uterine weight in intact rats
23. Lipopolysaccharide inhibits acetylcholine- and nitric oxide-mediated vasodilation in vivo
24. An evaluation of the novel selective estrogen receptor modulator, idoxifene, for effects on reproduction in rats and rabbits
25. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life