Lipopolysaccharide inhibits acetylcholine- and nitric oxide-mediated vasodilation in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 279, Issue 2, 1996, Pages 918-925

  Peters, Tamara S ^a   Lewis, Stephen J ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; BACTERIUM LIPOPOLYSACCHARIDE; DEXAMETHASONE; MUSCARINIC RECEPTOR; NITRIC OXIDE; NITROPRUSSIDE SODIUM; S NITROSOCYSTEINE; URETHAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENDOTHELIUM CELL; HEART OUTPUT; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; VASCULAR RESISTANCE; VASODILATATION;

ACETYLCHOLINE; ANIMALS; BLOOD PRESSURE; DEXAMETHASONE; LIPOPOLYSACCHARIDES; MALE; NITRIC OXIDE; NITROPRUSSIDE; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION;

EID: 0030432236     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. BOLOTINA, V. M., NAUIBI, S., PALACINO, J. J., PAGANO, P. J. AND COHEN, R. A.: Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature (Lond.) 368: 850-853, 1994.
2. BUSS, R. AND MULSCH A.: Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells. FEBS Lett. 275(1): 87-90, 1990.
3. FLEMING, I., GRAY, G. A., JULOU-SCHAEFFER, G., PARRATT, J. R. AND STOCLET J. C.: Incubation with endotoxin activates the L-arginine pathway in vascular tissue. Biochem. Biophys. Res. Comm. 171(2): 562-568, 1990.
4. GONZALES, C., FERNANDEZ, A., MARTIN, C., MONCADA, S. AND ESTRADA, C.: Nitric oxide from endothelium and smooth muscle modulates responses to sympathetic nerve stimulation: Implications for endotoxin shock. Biochem. Biophys. Res. Comm. 186(1): 150-156, 1992.
5. GOUREAU, O., LEPOIVRE, M. AND COURTOIS, Y.: Lipopolysaccharide and cytokines induce a macrophage-type of nitric oxide synthase in bovine retinal pigmented epithelial cells. Biochem. Biophys. Res. Comm. 186(2): 854-859, 1992.
6. GRAY, G. A., SCHOTT, C., JULOU-SCHAEFFER, G., FLEMING, I., PARRATT, J. R. AND STOCLET, J. C.: The effect of inhibitors of the L-arginine/nitric oxide pathway on endotoxin-induced loss of vascular responsiveness in anaesthetized rats. Br. J. Pharmacol. 103: 1218-1224, 1991.
7. GREENBERG, S., XIE, J., WANG, Y., CAI, B., KOLLS, J., NELSON, S., HYMAN, A., SUMMER, W. R. AND LIPPTON, H.: Tumor necrosis factor-alpha inhibits endothelium-dependent relaxation. J. Appl. Physiol. 74(5): 2394-2403, 1993.
8. HAYWOOD, J. R., SHAFFER, R. A., FASTENOW, C., FINK, D. D. AND BRODY, M. J.: Regional blood flow measurement with pulsed Doppler flowmeter in conscious rat. Am. J. Physiol. 241: H273-H278, 1981.
9. HESS, M. L., HASTILLO, A. AND GREENFIELD, L. J.: Spectrum of cardiovascular function during gram negative sepsis. Prog. Cardiovasc. Dis. 23: 279-298, 1981.
10. IGNARRO, L. J.: Nitric oxide: A novel signal transduction mechanism for transcellular communication. Hypertension 16: 477-483, 1990.
11. JULOU-SCHAEFFER, G., GRAY, G. A., FLEMING, I., SCHOTT, C., PAKRATT, J. R. AND STOCLET, J. C.: Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1038-H1043, 1990.
12. G-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide. Proc. Natl. Acad. Sci. U.S.A. 87: 3629-3632, 1990.
13. KNOWLES, R. G., SALTER, M., BROOKS, S. L. AND MONCADA, S.: Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat. Biochem. Biophys. Res. Comm. 172: 1042-1048, 1990.
14. KOWALUK, E. A. AND FUNG, H.: Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols. J. Pharmacol. Exp. Ther. 267: 1529-1537, 1990.
15. LACOLLEY, P. J., LEWIS, S. J. AND BRODY, M. J.: Role of sympathetic nerve activity in the generation of vascular nitric oxide in urethane-anesthetized rats. Hypertension. 17: 881-887, 1991.
16. LIPTON, S. A., CHOI, Y., PAN, Z., LEI, S. Z., CHEN, H. V., SUCHER, N. J., LOSCALZO, J., SINGEL, D. J. AND STAMLER, J. S.: A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature (Lond.) 364: 626-632, 1993.
17. LUSCHER, T. F. AND VANHOUTTE, P. M.: Production of contracting agents. In The Endothelium: Modulator of Cardiovascular Function, pp. 55-70, CRC Press, Boca Raton, FL, 1990.
18. MATHEWS, R. W. AND KERR, S. W.: Biological activity of S-nitrosothiols: The role of nitric oxide. J. Pharmacol. Exp. Ther. 267: 1529-1537, 1993.
19. MONCADA, S., PALMER, R. M. J. AND HIGGS, E. A.: Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol. Rev. 73: 109-142, 1991.
20. MYERS, P. R., MINOR, R. L. JR., GUERRA, R., JR., BATES, J. N. AND HARRISON, D. G.: Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature (Lond.) 345: 161-163, 1990.
21. MYERS, P. R., WRIGHT, T. F., TANNER, M. A. AND ADAM, H. R.: EDRF and nitric oxide production in cultured endothelial cells: Direct inhibition by E. coli endotoxin. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H710-H718, 1992.
22. PARKER, J. L., KELLER, R. S., DEFILY, D. V., LAUGHLIN, M. H., NOVOTNY, M. J. AND ADAMS, H. R.; Coronary vascular smooth muscle function in E. coli endotoxemia in dogs. Am. J. Physiol. 260 (Heart Circ. Physiol. 29: H832-H841, 1991.
23. PARRATT, J. R.: Alterations in vascular reactivity in sepsis and endotoxemia. In Update in Intensive Care and Emergency Medicine, ed. by J. L. Vincent, pp. 299-308, Berlin: Springer, 1989.
24. PARRILLO, J. E.: Septic shock in humans: Advances in the understanding of pathogenesis, cardiovascular dysfunction and therapy. Ann. Intern. Med. 113: 227-242, 1990.
25. PARRILLO, J. E., BURCH, C., SHELHAMER, J. H., PARKER, M. M., MATANSON, C. AND SCHUETTE, W.: A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. J. Clin. Invest. 76: 1539-1553, 1985.
26. RADOMSKI, M. W., PALMER, R. M. J. AND MONCADA, S.: Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 87: 10043-10047, 1990.
27. REES, D. D., CELLEK, S., PALMER, R. M. J. AND MONCADA, S.: Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock. Biochem. Biophys. Res. Comm. 173: 541-547, 1990.
28. ROSENBLUM, W. I.: Endothelium-derived relaxing factor in brain blood vessels is not nitric oxide. Stroke 23: 1527-1535, 1992.
29. RUBANYI, G. M., JOHN, A., WILCOX, D., BATES, J. N. AND HARRISON, D.: Evidence that a S-nitrosothiol, but not nitric oxide, may be identical with endothelium-derived relaxing factor. J. Cardiovasc. Pharmacol. 17: S41-S45, 1991.
30. SALVEMINI, D., KORBUT, R., ANGGARD, E. AND VANE, J.: Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide. Proc. Natl. Acad. Sci. U.S.A. 87: 2593-2597, 1990.
31. SALVEMNI, D., MOLLACE, V., PISTELLI, A., ANGGARD, E. AND VANE, J.: Metabolism of glycerol trinitrate to nitric oxide by endothelial cells and smooth muscle cells and its induction by Escherichia coli lipopolysaccharide. Prod. Natl. Acad. Sci. U.S.A. 89: 982-986, 1992.
32. 2+-independent nitric oxide synthase in the myocardium. Br. J. Pharmacol. 105: 575-580, 1992.
33. SMITH, R. E. A., PALMER, R. M. J. AND MONCADA, S.: Coronary vasodilation induced by endotoxin in the rabbit isolated perfused heart is nitric oxide-dependent and inhibited by dexamethasone. Br. J. Pharmacol. 108: 1107-1110, 1993.
34. STAMLER, J. S., SINGEL, D. J. AND LOSCALZO, J.: Biochemistry of nitric oxide and its redox-activated forms. Science (Wash. DC) 258: 1898-1902, 1992.
35. SZABO, C., MITCHELL, J. A., THIEMERMANN, C. AND VANE, J. R.: Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br. J. Pharmacol. 108: 786-792, 1993.
36. WALLENSTEIN, S., ZUCKER, C. L. AND FLEISS, J. L.: Some statistical methods useful in circulation research. Circ. Res. 47: 1-9, 1980.
37. WALLER, J., GARDINER, S. M. AND BENNETT, T.: Regional heamodynamic responses to acetylcholine, methoxamine, salbutamol and bradykinin during lipopolysaccharide infusion in conscious rats. Br. J. Pharmacol. 112(4): 1057-64, Aug. 1994.
38. WRIGHT, C. E., REES, D. D. AND MONCADA, S.: Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovaac. Res. 26: 48-57, 1992.
39. XIE, J., WANG, Y., LIPPTON, H., CAI, B., NELSON, S., ROLLS, J., SUMMER, W. R. AND GREENBERG, S. S.: Tumor necrosis factor inhibits stimulated but not basal release of nitric oxide. Am. Rev. Respir. Dis. 148: 627-636, 1993.
40. YOSHIZUMI, M., PERRELLA, M. A., BURNETT, J. C. JR. AND LEE, M. E.: Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life, Circ. Res. 78: 205-209, 1993.